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• W2109457943 endingPage "117" @default.
• W2109457943 startingPage "102" @default.
• W2109457943 abstract "Abstract Vitamin B6 (pyridoxal 5′-phosphate) is an essential cofactor of many metabolic enzymes. Plants biosynthesize the vitamin de novo employing two enzymes, pyridoxine synthase1 (PDX1) and PDX2. In Arabidopsis (Arabidopsis thaliana), there are two catalytically active paralogs of PDX1 (PDX1.1 and PDX1.3) producing the vitamin at comparable rates. Since single mutants are viable but the pdx1.1 pdx1.3 double mutant is lethal, the corresponding enzymes seem redundant. However, the single mutants exhibit substantial phenotypic differences, particularly at the level of root development, with pdx1.3 being more impaired than pdx1.1. Here, we investigate the differential regulation of PDX1.1 and PDX1.3 by identifying factors involved in their disparate phenotypes. Swapped-promoter experiments clarify the presence of distinct regulatory elements in the upstream regions of both genes. Exogenous sucrose (Suc) triggers impaired ethylene production in both mutants but is more severe in pdx1.3 than in pdx1.1. Interestingly, Suc specifically represses PDX1.1 expression, accounting for the stronger vitamin B6 deficit in pdx1.3 compared with pdx1.1. Surprisingly, Suc enhances auxin levels in pdx1.1, whereas the levels are diminished in pdx1.3. In the case of pdx1.3, the previously reported reduced meristem activity combined with the impaired ethylene and auxin levels manifest the specific root developmental defects. Moreover, it is the deficit in ethylene production and/or signaling that triggers this outcome. On the other hand, we hypothesize that it is the increased auxin content of pdx1.1 that is responsible for the root developmental defects observed therein. We conclude that PDX1.1 and PDX1.3 play partially nonredundant roles and are differentially regulated as manifested in disparate root growth impairment morphologies." @default.
• W2109457943 created "2016-06-24" @default.
• W2109457943 creator A5000832770 @default.
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• W2109457943 creator A5088559496 @default.
• W2109457943 date "2014-12-04" @default.
• W2109457943 modified "2023-09-29" @default.
• W2109457943 title "Consequences of a Deficit in Vitamin B6 Biosynthesis de Novo for Hormone Homeostasis and Root Development in Arabidopsis " @default.
• W2109457943 cites W1486089434 @default.
• W2109457943 cites W1502125994 @default.
• W2109457943 cites W1791475424 @default.
• W2109457943 cites W1826812957 @default.
• W2109457943 cites W1899903779 @default.
• W2109457943 cites W1962007356 @default.
• W2109457943 cites W1964867612 @default.
• W2109457943 cites W1965132968 @default.
• W2109457943 cites W1970204978 @default.
• W2109457943 cites W1979780010 @default.
• W2109457943 cites W1984967123 @default.
• W2109457943 cites W1987198662 @default.
• W2109457943 cites W1993251199 @default.
• W2109457943 cites W2001210598 @default.
• W2109457943 cites W2008580731 @default.
• W2109457943 cites W2008642796 @default.
• W2109457943 cites W2010004472 @default.
• W2109457943 cites W2012009609 @default.
• W2109457943 cites W2012598119 @default.
• W2109457943 cites W2017624229 @default.
• W2109457943 cites W2021323990 @default.
• W2109457943 cites W2022619265 @default.
• W2109457943 cites W2024556021 @default.
• W2109457943 cites W2029211347 @default.
• W2109457943 cites W2029298782 @default.
• W2109457943 cites W2029339280 @default.
• W2109457943 cites W2033280480 @default.
• W2109457943 cites W2037525379 @default.
• W2109457943 cites W2038736852 @default.
• W2109457943 cites W2039478787 @default.
• W2109457943 cites W2040885190 @default.
• W2109457943 cites W2043194010 @default.
• W2109457943 cites W2046892548 @default.
• W2109457943 cites W2048212541 @default.
• W2109457943 cites W2052460311 @default.
• W2109457943 cites W2055323344 @default.
• W2109457943 cites W2059019308 @default.
• W2109457943 cites W2061393819 @default.
• W2109457943 cites W2063462243 @default.
• W2109457943 cites W2069275373 @default.
• W2109457943 cites W2073376866 @default.
• W2109457943 cites W2073381449 @default.
• W2109457943 cites W2075746053 @default.
• W2109457943 cites W2081252762 @default.
• W2109457943 cites W2088234031 @default.
• W2109457943 cites W2089118630 @default.
• W2109457943 cites W2092321617 @default.
• W2109457943 cites W2097943925 @default.
• W2109457943 cites W2098382831 @default.
• W2109457943 cites W2102049179 @default.
• W2109457943 cites W2102383395 @default.
• W2109457943 cites W2102617567 @default.
• W2109457943 cites W2106596862 @default.
• W2109457943 cites W2107543053 @default.
• W2109457943 cites W2116122104 @default.
• W2109457943 cites W2117548944 @default.
• W2109457943 cites W2119906677 @default.
• W2109457943 cites W2129023473 @default.
• W2109457943 cites W2129169580 @default.
• W2109457943 cites W2132526816 @default.
• W2109457943 cites W2133184691 @default.
• W2109457943 cites W2138547583 @default.
• W2109457943 cites W2140834679 @default.
• W2109457943 cites W2141314326 @default.
• W2109457943 cites W2146660498 @default.
• W2109457943 cites W2147807626 @default.
• W2109457943 cites W2148295626 @default.
• W2109457943 cites W2148751085 @default.
• W2109457943 cites W2149098862 @default.
• W2109457943 cites W2150431323 @default.
• W2109457943 cites W2150851093 @default.
• W2109457943 cites W2152506161 @default.
• W2109457943 cites W2153167305 @default.
• W2109457943 cites W2153686019 @default.
• W2109457943 cites W2161098901 @default.
• W2109457943 cites W2163027365 @default.
• W2109457943 cites W2170455232 @default.
• W2109457943 cites W2171188988 @default.
• W2109457943 cites W4248077097 @default.
• W2109457943 doi "https://doi.org/10.1104/pp.114.247767" @default.
• W2109457943 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4281000" @default.
• W2109457943 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25475669" @default.
• W2109457943 hasPublicationYear "2014" @default.
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