Matches in SemOpenAlex for { <https://semopenalex.org/work/W2109458881> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2109458881 endingPage "791" @default.
- W2109458881 startingPage "786" @default.
- W2109458881 abstract "<h3>Abstract</h3> SARS-CoV-2 enters into human airway epithelial cells via membrane fusion or endocytosis, and this process is dependent on ACE2, TMPRSS2, and cathepsin L. In this study, we examined the expression profiles of the three SARS-CoV-2 entry-related genes in primary human airway epithelial cells isolated from donors with different physiological and pathological backgrounds such as smoking, COPD, asthma, lung cancer, allergic rhinitis, cystic fibrosis, or viral infections. By reanalyzing 54 GEO datasets comprising transcriptomic data of 3428 samples, this study revealed that i) smoking is associated with an increased expression of ACE2 and TMPRSS2 and a decreased expression of cathepsin L; ii) infection of rhinovirus as well as poly(I:C) stimulation leads to high expression of all three SARS-CoV-2 entry-related genes; iii) expression of ACE2 and cathepsin L in nasal epithelial cells are decreased in patients with asthma and allergic rhinitis. In conclusion, this study implicates that infection of respiratory viruses, cigarette smoking and allergic respiratory diseases might affect the susceptibility to and the development of COVID-19." @default.
- W2109458881 created "2016-06-24" @default.
- W2109458881 creator A5047659363 @default.
- W2109458881 creator A5048124766 @default.
- W2109458881 creator A5051416305 @default.
- W2109458881 creator A5059611749 @default.
- W2109458881 creator A5071171671 @default.
- W2109458881 creator A5087865591 @default.
- W2109458881 date "2005-08-01" @default.
- W2109458881 modified "2023-09-25" @default.
- W2109458881 title "A cluster randomised intervention trial of asthma clubs to improve quality of life in primary school children: the School Care and Asthma Management Project (SCAMP)" @default.
- W2109458881 cites W1650029743 @default.
- W2109458881 cites W1978489941 @default.
- W2109458881 cites W1980948687 @default.
- W2109458881 cites W1980960224 @default.
- W2109458881 cites W1984990222 @default.
- W2109458881 cites W1997714252 @default.
- W2109458881 cites W1998284769 @default.
- W2109458881 cites W2050480383 @default.
- W2109458881 cites W2052579897 @default.
- W2109458881 cites W2087009721 @default.
- W2109458881 cites W2087760311 @default.
- W2109458881 cites W2090517961 @default.
- W2109458881 cites W2099541134 @default.
- W2109458881 cites W2132995536 @default.
- W2109458881 cites W2154251580 @default.
- W2109458881 cites W2170892630 @default.
- W2109458881 cites W4320288061 @default.
- W2109458881 doi "https://doi.org/10.1136/adc.2004.062612" @default.
- W2109458881 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1720518" @default.
- W2109458881 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16040874" @default.
- W2109458881 hasPublicationYear "2005" @default.
- W2109458881 type Work @default.
- W2109458881 sameAs 2109458881 @default.
- W2109458881 citedByCount "39" @default.
- W2109458881 countsByYear W21094588812012 @default.
- W2109458881 countsByYear W21094588812013 @default.
- W2109458881 countsByYear W21094588812014 @default.
- W2109458881 countsByYear W21094588812015 @default.
- W2109458881 countsByYear W21094588812016 @default.
- W2109458881 countsByYear W21094588812017 @default.
- W2109458881 countsByYear W21094588812018 @default.
- W2109458881 countsByYear W21094588812019 @default.
- W2109458881 countsByYear W21094588812020 @default.
- W2109458881 countsByYear W21094588812021 @default.
- W2109458881 countsByYear W21094588812022 @default.
- W2109458881 crossrefType "journal-article" @default.
- W2109458881 hasAuthorship W2109458881A5047659363 @default.
- W2109458881 hasAuthorship W2109458881A5048124766 @default.
- W2109458881 hasAuthorship W2109458881A5051416305 @default.
- W2109458881 hasAuthorship W2109458881A5059611749 @default.
- W2109458881 hasAuthorship W2109458881A5071171671 @default.
- W2109458881 hasAuthorship W2109458881A5087865591 @default.
- W2109458881 hasBestOaLocation W21094588811 @default.
- W2109458881 hasConcept C126322002 @default.
- W2109458881 hasConcept C203014093 @default.
- W2109458881 hasConcept C2522874641 @default.
- W2109458881 hasConcept C2776042228 @default.
- W2109458881 hasConcept C2776780178 @default.
- W2109458881 hasConcept C2779278377 @default.
- W2109458881 hasConcept C534529494 @default.
- W2109458881 hasConcept C71924100 @default.
- W2109458881 hasConceptScore W2109458881C126322002 @default.
- W2109458881 hasConceptScore W2109458881C203014093 @default.
- W2109458881 hasConceptScore W2109458881C2522874641 @default.
- W2109458881 hasConceptScore W2109458881C2776042228 @default.
- W2109458881 hasConceptScore W2109458881C2776780178 @default.
- W2109458881 hasConceptScore W2109458881C2779278377 @default.
- W2109458881 hasConceptScore W2109458881C534529494 @default.
- W2109458881 hasConceptScore W2109458881C71924100 @default.
- W2109458881 hasIssue "8" @default.
- W2109458881 hasLocation W21094588811 @default.
- W2109458881 hasLocation W21094588812 @default.
- W2109458881 hasLocation W21094588813 @default.
- W2109458881 hasLocation W21094588814 @default.
- W2109458881 hasLocation W21094588815 @default.
- W2109458881 hasOpenAccess W2109458881 @default.
- W2109458881 hasPrimaryLocation W21094588811 @default.
- W2109458881 hasRelatedWork W1990992084 @default.
- W2109458881 hasRelatedWork W1991224820 @default.
- W2109458881 hasRelatedWork W2071113812 @default.
- W2109458881 hasRelatedWork W207774310 @default.
- W2109458881 hasRelatedWork W2083416394 @default.
- W2109458881 hasRelatedWork W2159959233 @default.
- W2109458881 hasRelatedWork W2382463158 @default.
- W2109458881 hasRelatedWork W2950165324 @default.
- W2109458881 hasRelatedWork W3027746149 @default.
- W2109458881 hasRelatedWork W3032129317 @default.
- W2109458881 hasVolume "90" @default.
- W2109458881 isParatext "false" @default.
- W2109458881 isRetracted "false" @default.
- W2109458881 magId "2109458881" @default.
- W2109458881 workType "article" @default.