Matches in SemOpenAlex for { <https://semopenalex.org/work/W2109468903> ?p ?o ?g. }
- W2109468903 endingPage "2058" @default.
- W2109468903 startingPage "2047" @default.
- W2109468903 abstract "Introduction: Dipeptidyl peptidase (DPP)-4 inhibitors belong to one class of drugs that have been approved for treatment of type 2 diabetes (T2D) based on the glucose-lowering actions of the gastrointestinal hormone glucagon-like peptide (GLP)-1. Several different compounds are now available, and although their mechanism of action (inhibition of the catalytic activity of DPP-4) is the same, there are fundamental differences between them. Areas covered: The authors discuss the differences between different DPP-4 inhibitors and review their therapeutic efficacy and key safety data. The literature covered includes original studies and meta-analyses identified in PubMed, recent abstracts presented at major diabetes scientific conferences, and clinical trials registered at ClinicalTrials.gov. Expert opinion: Although there are some differences in the pharmacokinetic and pharmacodynamic profiles of the different DPP-4 inhibitors, all are small orally active compounds with broadly similar HbA1c-lowering efficacy. They improve glycaemic control in T2D, without increasing the risk of hypoglycaemia or causing weight gain. They can be used as monotherapy or in combination with other anti-diabetic therapies, including insulin, regardless of renal or hepatic function, and are efficacious across the spectrum of patients with T2D, including those with long-standing disease duration. DPP-4 inhibitors may also have beneficial effects beyond glycaemic control, although this remains to be demonstrated in purpose-designed clinical trials." @default.
- W2109468903 created "2016-06-24" @default.
- W2109468903 creator A5054335526 @default.
- W2109468903 creator A5085434984 @default.
- W2109468903 date "2013-08-07" @default.
- W2109468903 modified "2023-10-14" @default.
- W2109468903 title "Dipeptidyl peptidase-4 inhibitors for the treatment of type 2 diabetes: comparison, efficacy and safety" @default.
- W2109468903 cites W1518038365 @default.
- W2109468903 cites W1547073044 @default.
- W2109468903 cites W1557233532 @default.
- W2109468903 cites W1569365382 @default.
- W2109468903 cites W1805640194 @default.
- W2109468903 cites W1865765771 @default.
- W2109468903 cites W1963514181 @default.
- W2109468903 cites W1969932276 @default.
- W2109468903 cites W1970638723 @default.
- W2109468903 cites W1976425553 @default.
- W2109468903 cites W1983130067 @default.
- W2109468903 cites W1985164695 @default.
- W2109468903 cites W1991951001 @default.
- W2109468903 cites W1995037892 @default.
- W2109468903 cites W1998401806 @default.
- W2109468903 cites W2007982994 @default.
- W2109468903 cites W2008286952 @default.
- W2109468903 cites W2008591744 @default.
- W2109468903 cites W2009969219 @default.
- W2109468903 cites W2017252684 @default.
- W2109468903 cites W2022096337 @default.
- W2109468903 cites W2024369575 @default.
- W2109468903 cites W2027744617 @default.
- W2109468903 cites W2028317115 @default.
- W2109468903 cites W2031848004 @default.
- W2109468903 cites W2038339878 @default.
- W2109468903 cites W2042207312 @default.
- W2109468903 cites W2042702624 @default.
- W2109468903 cites W2042845313 @default.
- W2109468903 cites W2043764971 @default.
- W2109468903 cites W2045321591 @default.
- W2109468903 cites W2045923887 @default.
- W2109468903 cites W2050984323 @default.
- W2109468903 cites W2054564814 @default.
- W2109468903 cites W2054925541 @default.
- W2109468903 cites W2055753691 @default.
- W2109468903 cites W2057913111 @default.
- W2109468903 cites W2058514432 @default.
- W2109468903 cites W2059154143 @default.
- W2109468903 cites W2067710447 @default.
- W2109468903 cites W2067736115 @default.
- W2109468903 cites W2075207587 @default.
- W2109468903 cites W2080247949 @default.
- W2109468903 cites W2081276121 @default.
- W2109468903 cites W2082960515 @default.
- W2109468903 cites W2084744936 @default.
- W2109468903 cites W2087025850 @default.
- W2109468903 cites W2087707716 @default.
- W2109468903 cites W2090445988 @default.
- W2109468903 cites W2092287139 @default.
- W2109468903 cites W2092361523 @default.
- W2109468903 cites W2094997999 @default.
- W2109468903 cites W2098008729 @default.
- W2109468903 cites W2099707525 @default.
- W2109468903 cites W2100987099 @default.
- W2109468903 cites W2102052385 @default.
- W2109468903 cites W2104079863 @default.
- W2109468903 cites W2106036385 @default.
- W2109468903 cites W2108292236 @default.
- W2109468903 cites W2108646121 @default.
- W2109468903 cites W2109688740 @default.
- W2109468903 cites W2109712315 @default.
- W2109468903 cites W2111876001 @default.
- W2109468903 cites W2112981414 @default.
- W2109468903 cites W2113985146 @default.
- W2109468903 cites W2114448619 @default.
- W2109468903 cites W2114927834 @default.
- W2109468903 cites W2115357902 @default.
- W2109468903 cites W2116254891 @default.
- W2109468903 cites W2121162069 @default.
- W2109468903 cites W2122696108 @default.
- W2109468903 cites W2125653714 @default.
- W2109468903 cites W2128243640 @default.
- W2109468903 cites W2129064931 @default.
- W2109468903 cites W2129248887 @default.
- W2109468903 cites W2131626154 @default.
- W2109468903 cites W2134161989 @default.
- W2109468903 cites W2134250131 @default.
- W2109468903 cites W2135141378 @default.
- W2109468903 cites W2136259411 @default.
- W2109468903 cites W2137982063 @default.
- W2109468903 cites W2143014102 @default.
- W2109468903 cites W2146289658 @default.
- W2109468903 cites W2148182710 @default.
- W2109468903 cites W2150859826 @default.
- W2109468903 cites W2151848850 @default.
- W2109468903 cites W2153323738 @default.
- W2109468903 cites W2154277743 @default.
- W2109468903 cites W2157665742 @default.
- W2109468903 cites W2158498099 @default.
- W2109468903 cites W2158506982 @default.