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- W2109471173 abstract "Recent studies have suggested a protective role of physiological β-amyloid autoantibodies (Aβ-autoantibodies) in Alzheimer’s disease (AD). However, the determination of both free and dissociated Aβ-autoantibodies in serum hitherto has yielded inconsistent results regarding their function and possible biomarker value. Here we report the application of a new sandwich enzyme-linked immunosorbent assay (ELISA) for the determination of antigen-bound Aβ-autoantibodies (intact Aβ-IgG immune complexes) in serum and cerebrospinal fluid (CSF) of a total number of 112 AD patients and age- and gender-matched control subjects. Both serum and CSF levels of Aβ-IgG immune complexes were found to be significantly higher in AD patients compared to control subjects. Moreover, the levels of Aβ-IgG complexes were negatively correlated with the cognitive status across the groups, increasing with declining cognitive test performance of the subjects. Our results suggest a contribution of IgG-type autoantibodies to Aβ clearance in vivo and an increased immune response in AD, which may be associated with deficient Aβ-IgG removal. These findings may contribute to elucidating the role of Aβ-autoantibodies in AD pathophysiology and their potential application in AD diagnosis." @default.
- W2109471173 created "2016-06-24" @default.
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- W2109471173 date "2013-07-18" @default.
- W2109471173 modified "2023-10-15" @default.
- W2109471173 title "Increased Levels of Antigen-Bound β-Amyloid Autoantibodies in Serum and Cerebrospinal Fluid of Alzheimer’s Disease Patients" @default.
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- W2109471173 doi "https://doi.org/10.1371/journal.pone.0068996" @default.
- W2109471173 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3715516" @default.
- W2109471173 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23874844" @default.
- W2109471173 hasPublicationYear "2013" @default.
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