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- W2109471230 startingPage "e848" @default.
- W2109471230 abstract "Pathways linking the thalamus and cortex mediate our daily shifts from states of attention to quiet rest, or sleep, yet little is known about their architecture in high-order neural systems associated with cognition, emotion and action. We provide novel evidence for neurochemical and synaptic specificity of two complementary circuits linking one such system, the prefrontal cortex with the ventral anterior thalamic nucleus in primates. One circuit originated from the neurochemical group of parvalbumin-positive thalamic neurons and projected focally through large terminals to the middle cortical layers, resembling ‘drivers’ in sensory pathways. Parvalbumin thalamic neurons, in turn, were innervated by small ‘modulatory’ type cortical terminals, forming asymmetric (presumed excitatory) synapses at thalamic sites enriched with the specialized metabotropic glutamate receptors. A second circuit had a complementary organization: it originated from the neurochemical group of calbindin-positive thalamic neurons and terminated through small ‘modulatory’ terminals over long distances in the superficial prefrontal layers. Calbindin thalamic neurons, in turn, were innervated by prefrontal axons through small and large terminals that formed asymmetric synapses preferentially at sites with ionotropic glutamate receptors, consistent with a driving pathway. The largely parallel thalamo-cortical pathways terminated among distinct and laminar-specific neurochemical classes of inhibitory neurons that differ markedly in inhibitory control. The balance of activation of these parallel circuits that link a high-order association cortex with the thalamus may allow shifts to different states of consciousness, in processes that are disrupted in psychiatric diseases." @default.
- W2109471230 created "2016-06-24" @default.
- W2109471230 creator A5014167212 @default.
- W2109471230 creator A5040764765 @default.
- W2109471230 date "2007-09-05" @default.
- W2109471230 modified "2023-10-11" @default.
- W2109471230 title "Parallel Driving and Modulatory Pathways Link the Prefrontal Cortex and Thalamus" @default.
- W2109471230 cites W1524744843 @default.
- W2109471230 cites W1541267199 @default.
- W2109471230 cites W1558475623 @default.
- W2109471230 cites W1586815491 @default.
- W2109471230 cites W1596185512 @default.
- W2109471230 cites W1694363227 @default.
- W2109471230 cites W1849206188 @default.
- W2109471230 cites W1963723452 @default.
- W2109471230 cites W1964711580 @default.
- W2109471230 cites W1964887266 @default.
- W2109471230 cites W1966248306 @default.
- W2109471230 cites W1967857491 @default.
- W2109471230 cites W1972328487 @default.
- W2109471230 cites W1979443476 @default.
- W2109471230 cites W1980114794 @default.
- W2109471230 cites W1982287446 @default.
- W2109471230 cites W1985777975 @default.
- W2109471230 cites W1988981158 @default.
- W2109471230 cites W1989486367 @default.
- W2109471230 cites W1994373202 @default.
- W2109471230 cites W1998995979 @default.
- W2109471230 cites W2001871185 @default.
- W2109471230 cites W2003723368 @default.
- W2109471230 cites W2005056698 @default.
- W2109471230 cites W2005352118 @default.
- W2109471230 cites W2007502604 @default.
- W2109471230 cites W2010613947 @default.
- W2109471230 cites W2018347727 @default.
- W2109471230 cites W2019964938 @default.
- W2109471230 cites W2026806992 @default.
- W2109471230 cites W2031492629 @default.
- W2109471230 cites W2033678367 @default.
- W2109471230 cites W2038505488 @default.
- W2109471230 cites W2040973912 @default.
- W2109471230 cites W2041349126 @default.
- W2109471230 cites W2043938544 @default.
- W2109471230 cites W2049040467 @default.
- W2109471230 cites W2054508155 @default.
- W2109471230 cites W2054710563 @default.
- W2109471230 cites W2055374196 @default.
- W2109471230 cites W2056390856 @default.
- W2109471230 cites W2059390121 @default.
- W2109471230 cites W2060478320 @default.
- W2109471230 cites W2062995163 @default.
- W2109471230 cites W2066923652 @default.
- W2109471230 cites W2067033192 @default.
- W2109471230 cites W2067976298 @default.
- W2109471230 cites W2068623304 @default.
- W2109471230 cites W2069536209 @default.
- W2109471230 cites W2071884714 @default.
- W2109471230 cites W2074462792 @default.
- W2109471230 cites W2074688705 @default.
- W2109471230 cites W2074725453 @default.
- W2109471230 cites W2076600981 @default.
- W2109471230 cites W2089218831 @default.
- W2109471230 cites W2090894153 @default.
- W2109471230 cites W2091166755 @default.
- W2109471230 cites W2091709166 @default.
- W2109471230 cites W2093640201 @default.
- W2109471230 cites W2103802045 @default.
- W2109471230 cites W2105805459 @default.
- W2109471230 cites W2107196928 @default.
- W2109471230 cites W2111405228 @default.
- W2109471230 cites W2112575206 @default.
- W2109471230 cites W2114835728 @default.
- W2109471230 cites W2114861541 @default.
- W2109471230 cites W2115255811 @default.
- W2109471230 cites W2116835712 @default.
- W2109471230 cites W2118429637 @default.
- W2109471230 cites W2118824504 @default.
- W2109471230 cites W2120223285 @default.
- W2109471230 cites W2120836623 @default.
- W2109471230 cites W2120872332 @default.
- W2109471230 cites W2121927821 @default.
- W2109471230 cites W2124486024 @default.
- W2109471230 cites W2124698022 @default.
- W2109471230 cites W2127120806 @default.
- W2109471230 cites W2127660458 @default.
- W2109471230 cites W2131541104 @default.
- W2109471230 cites W2139739279 @default.
- W2109471230 cites W2142784661 @default.
- W2109471230 cites W2145039080 @default.
- W2109471230 cites W2146639650 @default.
- W2109471230 cites W2155924534 @default.
- W2109471230 cites W2156598590 @default.
- W2109471230 cites W2156621206 @default.
- W2109471230 cites W2157032247 @default.
- W2109471230 cites W2159813274 @default.
- W2109471230 cites W2160094115 @default.
- W2109471230 cites W2161578473 @default.
- W2109471230 cites W2165892338 @default.