FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2109472386> ?p ?o ?g. }

• W2109472386 endingPage "53" @default.
• W2109472386 startingPage "2541" @default.
• W2109472386 abstract "Recently synthesis of programmable DNA ligands which can regulate transcription factors have increased the interest of researchers on the functional ability of DNA interacting compounds. A series of DNA interacting compounds are being designed which can differentiate between GC and AT rich DNA. In this study, we have studied the specificity of a few novel bisbenzimidazoles having different bi/tri-substituted phenyl rings, with DNA duplexes using spectroscopic methods. This study entails an integrative approach where we combine biophysical methods and molecular dynamics simulation studies to establish suitable scaffolds to target A/T DNA. We have designed a few analogues of Hoechst 33342 viz.; dimethoxy (DMA), trimethoxy (TMA), dichloro (DCA) and difluoro (DFA) functionalities and performed molecular docking of newly designed analogues with biologically relevant AT and GC rich DNA sequences. The docking studies, along with molecular dynamics (MD) simulations of d(ATATATATATATATAT)2, d(GA4T4C)2, d(GT4A4C)2 and GC rich sequence: d(GCGCGCGCGCGCGCGC)2 complexed with DMA, TMA and DFA, showed that these molecules have higher binding affinity towards AT rich DNA. None of these compounds exhibited an affinity to GC rich DNA rather we observed that these compounds destabilize GC rich DNA. The binding was characterized by strong stabilization of the polynucleotides against thermal strand separation in thermal melting experiments. New insights into the molecules binding to DNA have emerged from these studies. All the DNA binding ligands stabilized d(GA4T4C)2 and d(GT4A4C)2 more out of the five oligomers used for the study, suggesting that these ligands bind 'A4T4' and 'T4A4' strongly as compared to 'ATAT' base pairs." @default.
• W2109472386 created "2016-06-24" @default.
• W2109472386 creator A5000184114 @default.
• W2109472386 creator A5043437093 @default.
• W2109472386 creator A5065853743 @default.
• W2109472386 creator A5070438420 @default.
• W2109472386 creator A5082881740 @default.
• W2109472386 date "2013-10-01" @default.
• W2109472386 modified "2023-09-26" @default.
• W2109472386 title "Bi and tri-substituted phenyl rings containing bisbenzimidazoles bind differentially with DNA duplexes: a biophysical and molecular simulation study." @default.
• W2109472386 cites W1966851289 @default.
• W2109472386 cites W1972864160 @default.
• W2109472386 cites W1977338874 @default.
• W2109472386 cites W1981515543 @default.
• W2109472386 cites W1985982026 @default.
• W2109472386 cites W1987546290 @default.
• W2109472386 cites W1995673527 @default.
• W2109472386 cites W1998572249 @default.
• W2109472386 cites W2001571624 @default.
• W2109472386 cites W2008737360 @default.
• W2109472386 cites W2019417006 @default.
• W2109472386 cites W2020937281 @default.
• W2109472386 cites W2021416089 @default.
• W2109472386 cites W2028753366 @default.
• W2109472386 cites W2029667189 @default.
• W2109472386 cites W2031404206 @default.
• W2109472386 cites W2032525446 @default.
• W2109472386 cites W2038985545 @default.
• W2109472386 cites W2040471923 @default.
• W2109472386 cites W2040952160 @default.
• W2109472386 cites W2055330746 @default.
• W2109472386 cites W2070005055 @default.
• W2109472386 cites W2075556249 @default.
• W2109472386 cites W2081575273 @default.
• W2109472386 cites W2087760339 @default.
• W2109472386 cites W2090196960 @default.
• W2109472386 cites W2090388168 @default.
• W2109472386 cites W2096577501 @default.
• W2109472386 cites W2097124464 @default.
• W2109472386 cites W2098451503 @default.
• W2109472386 cites W2108226564 @default.
• W2109472386 cites W2117152823 @default.
• W2109472386 cites W2119723870 @default.
• W2109472386 cites W2123628707 @default.
• W2109472386 cites W2132629607 @default.
• W2109472386 cites W2133443490 @default.
• W2109472386 cites W2161634017 @default.
• W2109472386 cites W2168278222 @default.
• W2109472386 cites W2171943984 @default.
• W2109472386 cites W2197691169 @default.
• W2109472386 cites W2233961908 @default.
• W2109472386 doi "https://doi.org/10.1039/c3mb70169g" @default.
• W2109472386 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23921527" @default.
• W2109472386 hasPublicationYear "2013" @default.
• W2109472386 type Work @default.
• W2109472386 sameAs 2109472386 @default.
• W2109472386 citedByCount "4" @default.
• W2109472386 countsByYear W21094723862014 @default.
• W2109472386 countsByYear W21094723862015 @default.
• W2109472386 countsByYear W21094723862022 @default.
• W2109472386 countsByYear W21094723862023 @default.
• W2109472386 crossrefType "journal-article" @default.
• W2109472386 hasAuthorship W2109472386A5000184114 @default.
• W2109472386 hasAuthorship W2109472386A5043437093 @default.
• W2109472386 hasAuthorship W2109472386A5065853743 @default.
• W2109472386 hasAuthorship W2109472386A5070438420 @default.
• W2109472386 hasAuthorship W2109472386A5082881740 @default.
• W2109472386 hasConcept C111921641 @default.
• W2109472386 hasConcept C12554922 @default.
• W2109472386 hasConcept C147597530 @default.
• W2109472386 hasConcept C159110408 @default.
• W2109472386 hasConcept C178790620 @default.
• W2109472386 hasConcept C178910836 @default.
• W2109472386 hasConcept C185592680 @default.
• W2109472386 hasConcept C191961535 @default.
• W2109472386 hasConcept C21951064 @default.
• W2109472386 hasConcept C32909587 @default.
• W2109472386 hasConcept C41685203 @default.
• W2109472386 hasConcept C552990157 @default.
• W2109472386 hasConcept C55493867 @default.
• W2109472386 hasConcept C59593255 @default.
• W2109472386 hasConcept C71240020 @default.
• W2109472386 hasConcept C71924100 @default.
• W2109472386 hasConcept C86803240 @default.
• W2109472386 hasConceptScore W2109472386C111921641 @default.
• W2109472386 hasConceptScore W2109472386C12554922 @default.
• W2109472386 hasConceptScore W2109472386C147597530 @default.
• W2109472386 hasConceptScore W2109472386C159110408 @default.
• W2109472386 hasConceptScore W2109472386C178790620 @default.
• W2109472386 hasConceptScore W2109472386C178910836 @default.
• W2109472386 hasConceptScore W2109472386C185592680 @default.
• W2109472386 hasConceptScore W2109472386C191961535 @default.
• W2109472386 hasConceptScore W2109472386C21951064 @default.
• W2109472386 hasConceptScore W2109472386C32909587 @default.
• W2109472386 hasConceptScore W2109472386C41685203 @default.
• W2109472386 hasConceptScore W2109472386C552990157 @default.
• W2109472386 hasConceptScore W2109472386C55493867 @default.
• W2109472386 hasConceptScore W2109472386C59593255 @default.

• next