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• W2109476095 startingPage "1907" @default.
• W2109476095 abstract "Gene expression in eukaryotes is often enhanced by the presence of introns. Depending on the specific gene, this enhancement can be minor or very large and occurs at both the transcriptional and post-transcriptional levels. The Arabidopsis ERECTA gene contains 27 exons encoding a receptor-like kinase that promotes cell proliferation and inhibits cell differentiation in above-ground plant organs. The expression of ERECTA very strongly depends on the presence of introns. The intronless ERECTA gene does not rescue the phenotype of erecta mutant plants and produces about 500–900 times less protein compared with the identical construct containing introns. This result is somewhat surprising as the region upstream of the ERECTA coding sequence effectively promotes the expression of extraneous genes. Here, we demonstrate that introns are essential for ERECTA mRNA accumulation and, to a lesser extent, for mRNA utilization in translation. Since mRNA produced by intronless ERECTA is degraded at the 3′ end, we speculate that introns increase mRNA accumulation through increasing its stability at least in part. No individual intron is absolutely necessary for ERECTA expression, but rather multiple introns in specific locations increase ERECTA expression in an additive manner. The ability of introns to promote ERECTA expression might be linked to the process of splicing and not to a particular intron sequence." @default.
• W2109476095 created "2016-06-24" @default.
• W2109476095 creator A5017046005 @default.
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• W2109476095 date "2011-08-31" @default.
• W2109476095 modified "2023-10-18" @default.
• W2109476095 title "The presence of multiple introns is essential for <i>ERECTA</i> expression in <i>Arabidopsis</i>" @default.
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• W2109476095 doi "https://doi.org/10.1261/rna.2825811" @default.
• W2109476095 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3185922" @default.
• W2109476095 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21880780" @default.
• W2109476095 hasPublicationYear "2011" @default.
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