FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2109478037> ?p ?o ?g. }

• W2109478037 endingPage "6617" @default.
• W2109478037 startingPage "6610" @default.
• W2109478037 abstract "Preexposure prophylaxis (PrEP) with antiretroviral drugs is a novel human immunodeficiency virus (HIV) prevention strategy. It is generally thought that high systemic and mucosal drug levels are sufficient for protection. We investigated whether GS7340, a next-generation tenofovir (TFV) prodrug that effectively delivers tenofovir diphosphate (TFV-DP) to lymphoid cells and tissues, could protect macaques against repeated weekly rectal simian-human immunodeficiency virus (SHIV) exposures. Macaques received prophylactic GS7340 treatment 3 days prior to each virus exposure. At 3 days postdosing, TFV-DP concentrations in peripheral blood mononuclear cells (PBMCs) were about 50-fold higher than those seen with TFV disoproxil fumarate (TDF), and they remained above 1,000 fmol/10(6) cells for as long as 7 days. TFV-DP accumulated in lymphoid and rectal tissues, with concentrations at 3 days exceeding 500 fmol/10(6) mononuclear cells. Despite high mucosal and systemic TFV levels, GS7340 was not protective. Since TFV-DP blocks reverse transcription by competing with the natural dATP substrate, we measured dATP contents in peripheral lymphocytes, lymphoid tissue, and rectal mononuclear cells. Compared to those in circulating lymphocytes and lymphoid tissue, rectal lymphocytes had 100-fold higher dATP concentrations and dATP/TFV-DP ratios, likely reflecting the activated status of the cells and suggesting that TFV-DP may be less active at the rectal mucosa. Our results identify dATP/TFV-DP ratios as a possible correlate of protection by TFV and suggest that natural substrate concentrations at the mucosa will likely modulate the prophylactic efficacy of nucleotide reverse transcriptase inhibitors." @default.
• W2109478037 created "2016-06-24" @default.
• W2109478037 creator A5005734336 @default.
• W2109478037 creator A5006917814 @default.
• W2109478037 creator A5008696015 @default.
• W2109478037 creator A5018396206 @default.
• W2109478037 creator A5019037088 @default.
• W2109478037 creator A5031077639 @default.
• W2109478037 creator A5031496742 @default.
• W2109478037 creator A5035169875 @default.
• W2109478037 creator A5041952304 @default.
• W2109478037 creator A5045831239 @default.
• W2109478037 creator A5048498718 @default.
• W2109478037 creator A5049620208 @default.
• W2109478037 creator A5052972524 @default.
• W2109478037 creator A5055425525 @default.
• W2109478037 creator A5061144516 @default.
• W2109478037 creator A5063493697 @default.
• W2109478037 creator A5072275302 @default.
• W2109478037 creator A5073085036 @default.
• W2109478037 date "2011-07-01" @default.
• W2109478037 modified "2023-10-18" @default.
• W2109478037 title "Natural Substrate Concentrations Can Modulate the Prophylactic Efficacy of Nucleotide HIV Reverse Transcriptase Inhibitors" @default.
• W2109478037 cites W1552261986 @default.
• W2109478037 cites W1955224405 @default.
• W2109478037 cites W1964085252 @default.
• W2109478037 cites W1965879343 @default.
• W2109478037 cites W1970506670 @default.
• W2109478037 cites W1993650351 @default.
• W2109478037 cites W1998150497 @default.
• W2109478037 cites W2005655629 @default.
• W2109478037 cites W2022314336 @default.
• W2109478037 cites W2023257490 @default.
• W2109478037 cites W2023458475 @default.
• W2109478037 cites W2041895046 @default.
• W2109478037 cites W2043409853 @default.
• W2109478037 cites W2045989889 @default.
• W2109478037 cites W2046348452 @default.
• W2109478037 cites W2051113619 @default.
• W2109478037 cites W2051664921 @default.
• W2109478037 cites W2074189989 @default.
• W2109478037 cites W2075308602 @default.
• W2109478037 cites W2079551453 @default.
• W2109478037 cites W2097057569 @default.
• W2109478037 cites W2103920597 @default.
• W2109478037 cites W2108713704 @default.
• W2109478037 cites W2116605213 @default.
• W2109478037 cites W2118045361 @default.
• W2109478037 cites W2132008472 @default.
• W2109478037 cites W2134388482 @default.
• W2109478037 cites W2137609866 @default.
• W2109478037 cites W2149492547 @default.
• W2109478037 cites W2150484278 @default.
• W2109478037 cites W2154916896 @default.
• W2109478037 cites W2157984912 @default.
• W2109478037 cites W2158513952 @default.
• W2109478037 cites W2162845814 @default.
• W2109478037 cites W2171637842 @default.
• W2109478037 doi "https://doi.org/10.1128/jvi.00311-11" @default.
• W2109478037 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3126530" @default.
• W2109478037 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21525346" @default.
• W2109478037 hasPublicationYear "2011" @default.
• W2109478037 type Work @default.
• W2109478037 sameAs 2109478037 @default.
• W2109478037 citedByCount "70" @default.
• W2109478037 countsByYear W21094780372012 @default.
• W2109478037 countsByYear W21094780372013 @default.
• W2109478037 countsByYear W21094780372014 @default.
• W2109478037 countsByYear W21094780372015 @default.
• W2109478037 countsByYear W21094780372016 @default.
• W2109478037 countsByYear W21094780372017 @default.
• W2109478037 countsByYear W21094780372018 @default.
• W2109478037 countsByYear W21094780372019 @default.
• W2109478037 countsByYear W21094780372020 @default.
• W2109478037 countsByYear W21094780372021 @default.
• W2109478037 countsByYear W21094780372022 @default.
• W2109478037 countsByYear W21094780372023 @default.
• W2109478037 crossrefType "journal-article" @default.
• W2109478037 hasAuthorship W2109478037A5005734336 @default.
• W2109478037 hasAuthorship W2109478037A5006917814 @default.
• W2109478037 hasAuthorship W2109478037A5008696015 @default.
• W2109478037 hasAuthorship W2109478037A5018396206 @default.
• W2109478037 hasAuthorship W2109478037A5019037088 @default.
• W2109478037 hasAuthorship W2109478037A5031077639 @default.
• W2109478037 hasAuthorship W2109478037A5031496742 @default.
• W2109478037 hasAuthorship W2109478037A5035169875 @default.
• W2109478037 hasAuthorship W2109478037A5041952304 @default.
• W2109478037 hasAuthorship W2109478037A5045831239 @default.
• W2109478037 hasAuthorship W2109478037A5048498718 @default.
• W2109478037 hasAuthorship W2109478037A5049620208 @default.
• W2109478037 hasAuthorship W2109478037A5052972524 @default.
• W2109478037 hasAuthorship W2109478037A5055425525 @default.
• W2109478037 hasAuthorship W2109478037A5061144516 @default.
• W2109478037 hasAuthorship W2109478037A5063493697 @default.
• W2109478037 hasAuthorship W2109478037A5072275302 @default.
• W2109478037 hasAuthorship W2109478037A5073085036 @default.
• W2109478037 hasBestOaLocation W21094780371 @default.
• W2109478037 hasConcept C104317684 @default.

• next