FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2109479523> ?p ?o ?g. }

• W2109479523 endingPage "1630" @default.
• W2109479523 startingPage "1624" @default.
• W2109479523 abstract "Atherosclerotic cardiovascular disease, malnutrition, and increased levels of pro-inflammatory cytokines are common features in patients with chronic renal failure, and contribute to the high mortality rate observed in these patients. A diverse group of soluble cellular adhesion molecules (CAM) (sVCAM-1, sICAM-1 and sE-selectin) are expressed on the surface of vascular endothelial cells in response to pro-inflammatory cytokines and may play an important role in the atherogenic process.Serum levels of sVCAM-1, sICAM-1 (n=87) and sE-selectin (n=71) were analysed in a cohort of 88 patients (50+/-1 years) with chronic renal failure. The presence of malnutrition (subjective global assessment (SGA) and serum albumin), inflammation (C-reactive protein (CRP), tumour necrosis factor-alpha (TNF-alpha), and serum hyaluronan), and cardiovascular disease (CVD) were assessed at a time-point close to the start of dialysis treatment (GFR 7+/-1 ml/min). Blood lipid parameters were also assessed.Significant correlations were observed between Log high-sensitivity CRP (hsCRP) and sVCAM-1 (R=0.39; P<0.01) and sICAM-1 (R=0.47; P:<0.001) levels but not between Log hsCRP and sE-selectin levels in 60 patients examined with a hsCRP assay. Also serum concentrations of Log hyaluronan correlated significantly to sVCAM-1 (R=0.34; P<0.01) and sICAM-1 (R=0.29; P<0.05) levels. Malnourished patients (SGA>1) had elevated serum concentrations of sVCAM-1 (1436+/-94 vs. 1105+/-53 ng/ml; P<0.01) compared to well-nourished patients (SGA 1). Patients with clinical signs of CVD (n=26) had elevated serum levels of sICAM-1 (282+/-18 vs. 242+/-9 ng/ml; P<0.05) compared to 61 patients without signs of CVD. Plasma Log lipoprotein (a) (Lp(a)) levels correlated significantly with sVCAM-1 (R=0.30; P<0.01). Survival analysis by the Cox regression model showed that elevated sICAM-1 was, independent of age, SGA, CVD, and Log CRP, significantly related to an increased mortality rate.Elevated serum concentrations of soluble adhesion molecules are found in pre-dialysis patients who are malnourished, inflamed, and have signs of cardiovascular disease. These data also suggest that sICAM-1 is an independent predictor of mortality in pre-dialysis patients. Further studies are needed to determine if inflammation causes accelerated atherogenesis via effects on soluble adhesion molecules or if elevated serum levels of soluble adhesion molecules are merely markers of endothelial activation in patients with chronic renal failure." @default.
• W2109479523 created "2016-06-24" @default.
• W2109479523 creator A5045807220 @default.
• W2109479523 creator A5052735853 @default.
• W2109479523 creator A5075312959 @default.
• W2109479523 creator A5085007630 @default.
• W2109479523 date "2000-10-01" @default.
• W2109479523 modified "2023-10-02" @default.
• W2109479523 title "Elevated serum levels of soluble adhesion molecules predict death in pre‐dialysis patients: association with malnutrition, inflammation, and cardiovascular disease" @default.
• W2109479523 cites W1517965101 @default.
• W2109479523 cites W1870892720 @default.
• W2109479523 cites W1963936317 @default.
• W2109479523 cites W1964498019 @default.
• W2109479523 cites W1966690086 @default.
• W2109479523 cites W1970008507 @default.
• W2109479523 cites W1972919038 @default.
• W2109479523 cites W1976823107 @default.
• W2109479523 cites W1983338308 @default.
• W2109479523 cites W1983523234 @default.
• W2109479523 cites W1985292239 @default.
• W2109479523 cites W1992919156 @default.
• W2109479523 cites W2002565780 @default.
• W2109479523 cites W2025589168 @default.
• W2109479523 cites W2032457360 @default.
• W2109479523 cites W2034490130 @default.
• W2109479523 cites W2038523160 @default.
• W2109479523 cites W2052034325 @default.
• W2109479523 cites W2052704549 @default.
• W2109479523 cites W2053437995 @default.
• W2109479523 cites W2054571110 @default.
• W2109479523 cites W2058610272 @default.
• W2109479523 cites W2061710689 @default.
• W2109479523 cites W2062945994 @default.
• W2109479523 cites W2068949553 @default.
• W2109479523 cites W2070093958 @default.
• W2109479523 cites W2073968460 @default.
• W2109479523 cites W2081385953 @default.
• W2109479523 cites W2083217753 @default.
• W2109479523 cites W2089491627 @default.
• W2109479523 cites W2091248176 @default.
• W2109479523 cites W2091743973 @default.
• W2109479523 cites W2093987716 @default.
• W2109479523 cites W2099437730 @default.
• W2109479523 cites W2100994529 @default.
• W2109479523 cites W2115184014 @default.
• W2109479523 cites W2137098613 @default.
• W2109479523 cites W2138809584 @default.
• W2109479523 cites W2150078273 @default.
• W2109479523 cites W2169272593 @default.
• W2109479523 cites W2314369677 @default.
• W2109479523 cites W2466932343 @default.
• W2109479523 cites W4313310025 @default.
• W2109479523 doi "https://doi.org/10.1093/ndt/15.10.1624" @default.
• W2109479523 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11007832" @default.
• W2109479523 hasPublicationYear "2000" @default.
• W2109479523 type Work @default.
• W2109479523 sameAs 2109479523 @default.
• W2109479523 citedByCount "164" @default.
• W2109479523 countsByYear W21094795232012 @default.
• W2109479523 countsByYear W21094795232013 @default.
• W2109479523 countsByYear W21094795232014 @default.
• W2109479523 countsByYear W21094795232015 @default.
• W2109479523 countsByYear W21094795232016 @default.
• W2109479523 countsByYear W21094795232017 @default.
• W2109479523 countsByYear W21094795232018 @default.
• W2109479523 countsByYear W21094795232019 @default.
• W2109479523 countsByYear W21094795232020 @default.
• W2109479523 countsByYear W21094795232021 @default.
• W2109479523 countsByYear W21094795232022 @default.
• W2109479523 countsByYear W21094795232023 @default.
• W2109479523 crossrefType "journal-article" @default.
• W2109479523 hasAuthorship W2109479523A5045807220 @default.
• W2109479523 hasAuthorship W2109479523A5052735853 @default.
• W2109479523 hasAuthorship W2109479523A5075312959 @default.
• W2109479523 hasAuthorship W2109479523A5085007630 @default.
• W2109479523 hasConcept C126322002 @default.
• W2109479523 hasConcept C134018914 @default.
• W2109479523 hasConcept C165616093 @default.
• W2109479523 hasConcept C17991360 @default.
• W2109479523 hasConcept C203014093 @default.
• W2109479523 hasConcept C2776125364 @default.
• W2109479523 hasConcept C2776246508 @default.
• W2109479523 hasConcept C2776914184 @default.
• W2109479523 hasConcept C2778063415 @default.
• W2109479523 hasConcept C2778653478 @default.
• W2109479523 hasConcept C2779978075 @default.
• W2109479523 hasConcept C2780972559 @default.
• W2109479523 hasConcept C2781195455 @default.
• W2109479523 hasConcept C551997983 @default.
• W2109479523 hasConcept C71924100 @default.
• W2109479523 hasConcept C90924648 @default.
• W2109479523 hasConceptScore W2109479523C126322002 @default.
• W2109479523 hasConceptScore W2109479523C134018914 @default.
• W2109479523 hasConceptScore W2109479523C165616093 @default.
• W2109479523 hasConceptScore W2109479523C17991360 @default.
• W2109479523 hasConceptScore W2109479523C203014093 @default.
• W2109479523 hasConceptScore W2109479523C2776125364 @default.
• W2109479523 hasConceptScore W2109479523C2776246508 @default.

• next