FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2109479562> ?p ?o ?g. }

• W2109479562 endingPage "115" @default.
• W2109479562 startingPage "105" @default.
• W2109479562 abstract "The distribution of omega-6 and omega-3 polyunsaturated fatty acid (PUFA) intake in Western diets is disproportionate, containing an overabundance of the omega-6 PUFA, linoleic acid (LA; C18:2). Increased enrichment with LA has been shown to contribute to the enhancement of tumorigenesis in several cancer models. Previous work has indicated that phosphatidylinositol 3-kinase (PI3K) may play a key role in LA-induced tumorigenesis. However, the modes by which LA affects carcinogenesis have not been fully elucidated. In this study, a mechanism for LA-induced upregulation of cancer cell growth is defined. LA treatment enhanced cellular proliferation in BT-474 human breast ductal carcinoma and A549 human lung adenocarcinoma cell lines. Enrichment of LA increased cyclooxygenase (COX) activity and led to increases in prostaglandin E2 (PGE2), followed by increases in matrix metalloproteinase (MMP) and transforming growth factor alpha (TGF-α) levels, which are all key elements involved in the enhancement of cancer cell growth. Further investigation revealed that LA supplementation in both BT-474 breast and A549 lung cancer cell lines greatly increased the association between the scaffolding protein GRB2-associated-binding protein 1 (Gab1) and epidermal growth factor receptor (EGFR), although Gab1 protein levels were significantly decreased. These LA-induced changes were associated with increases in activated Akt (pAkt), a downstream signaling component in the PI3K pathway. Treatment with inhibitors of EGFR, PI3K and Gab1-specific siRNAs reversed the upregulation of pAkt, as well as the observed increases in cell proliferation by LA in both cell lines. A549 xenograft assessment in athymic nude mice fed high levels of LA exhibited similar increases in EGFR-Gab1 association and increased levels of pAkt, while mice fed with high levels of the omega-3 PUFA, docosahexaenoic acid (DHA; C22:6), demonstrated an opposite response. The involvement of Gab1 in LA-induced tumorigenesis was further defined utilizing murine cell lines that express high levels of Gab1. Significant increases in cell proliferation were observed with the addition of increasing concentrations of LA. However, no changes in cell proliferation were detected in the murine paired cell lines expressing little or no Gab1 protein, establishing Gab1 as major target in LA-induced enhancement of tumorigenesis." @default.
• W2109479562 created "2016-06-24" @default.
• W2109479562 creator A5019260877 @default.
• W2109479562 creator A5058807269 @default.
• W2109479562 creator A5062453788 @default.
• W2109479562 creator A5071836349 @default.
• W2109479562 creator A5077832022 @default.
• W2109479562 date "2014-04-01" @default.
• W2109479562 modified "2023-10-03" @default.
• W2109479562 title "Key roles for GRB2-associated-binding protein 1, phosphatidylinositol-3-kinase, cyclooxygenase 2, prostaglandin E2 and transforming growth factor alpha in linoleic acid-induced upregulation of lung and breast cancer cell growth" @default.
• W2109479562 cites W1974223107 @default.
• W2109479562 cites W1974247024 @default.
• W2109479562 cites W1977267072 @default.
• W2109479562 cites W1977533506 @default.
• W2109479562 cites W1979654645 @default.
• W2109479562 cites W1981131216 @default.
• W2109479562 cites W1983519516 @default.
• W2109479562 cites W1988458275 @default.
• W2109479562 cites W1992944693 @default.
• W2109479562 cites W1995466607 @default.
• W2109479562 cites W1996416600 @default.
• W2109479562 cites W2000183234 @default.
• W2109479562 cites W2006221512 @default.
• W2109479562 cites W2009718837 @default.
• W2109479562 cites W2010260780 @default.
• W2109479562 cites W2032664016 @default.
• W2109479562 cites W2033283286 @default.
• W2109479562 cites W2045080266 @default.
• W2109479562 cites W2050341558 @default.
• W2109479562 cites W2054293749 @default.
• W2109479562 cites W2073738021 @default.
• W2109479562 cites W2076630765 @default.
• W2109479562 cites W2077462602 @default.
• W2109479562 cites W2077871783 @default.
• W2109479562 cites W2088556524 @default.
• W2109479562 cites W2107277218 @default.
• W2109479562 cites W2108099675 @default.
• W2109479562 cites W2116488160 @default.
• W2109479562 cites W2128782161 @default.
• W2109479562 cites W2133336565 @default.
• W2109479562 cites W2148343146 @default.
• W2109479562 cites W2149866700 @default.
• W2109479562 cites W2161821474 @default.
• W2109479562 cites W2163074585 @default.
• W2109479562 cites W2166711885 @default.
• W2109479562 cites W2168526937 @default.
• W2109479562 cites W2320052151 @default.
• W2109479562 cites W2569177514 @default.
• W2109479562 doi "https://doi.org/10.1016/j.plefa.2013.12.001" @default.
• W2109479562 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4138981" @default.
• W2109479562 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24374147" @default.
• W2109479562 hasPublicationYear "2014" @default.
• W2109479562 type Work @default.
• W2109479562 sameAs 2109479562 @default.
• W2109479562 citedByCount "30" @default.
• W2109479562 countsByYear W21094795622014 @default.
• W2109479562 countsByYear W21094795622015 @default.
• W2109479562 countsByYear W21094795622016 @default.
• W2109479562 countsByYear W21094795622017 @default.
• W2109479562 countsByYear W21094795622018 @default.
• W2109479562 countsByYear W21094795622019 @default.
• W2109479562 countsByYear W21094795622020 @default.
• W2109479562 countsByYear W21094795622021 @default.
• W2109479562 countsByYear W21094795622022 @default.
• W2109479562 countsByYear W21094795622023 @default.
• W2109479562 crossrefType "journal-article" @default.
• W2109479562 hasAuthorship W2109479562A5019260877 @default.
• W2109479562 hasAuthorship W2109479562A5058807269 @default.
• W2109479562 hasAuthorship W2109479562A5062453788 @default.
• W2109479562 hasAuthorship W2109479562A5071836349 @default.
• W2109479562 hasAuthorship W2109479562A5077832022 @default.
• W2109479562 hasBestOaLocation W21094795622 @default.
• W2109479562 hasConcept C104317684 @default.
• W2109479562 hasConcept C121608353 @default.
• W2109479562 hasConcept C125555471 @default.
• W2109479562 hasConcept C126322002 @default.
• W2109479562 hasConcept C127561419 @default.
• W2109479562 hasConcept C134018914 @default.
• W2109479562 hasConcept C170493617 @default.
• W2109479562 hasConcept C185592680 @default.
• W2109479562 hasConcept C2776362946 @default.
• W2109479562 hasConcept C502942594 @default.
• W2109479562 hasConcept C55493867 @default.
• W2109479562 hasConcept C555283112 @default.
• W2109479562 hasConcept C62112901 @default.
• W2109479562 hasConcept C62478195 @default.
• W2109479562 hasConcept C71924100 @default.
• W2109479562 hasConcept C75217442 @default.
• W2109479562 hasConcept C86554907 @default.
• W2109479562 hasConcept C86803240 @default.
• W2109479562 hasConcept C95444343 @default.
• W2109479562 hasConceptScore W2109479562C104317684 @default.
• W2109479562 hasConceptScore W2109479562C121608353 @default.
• W2109479562 hasConceptScore W2109479562C125555471 @default.
• W2109479562 hasConceptScore W2109479562C126322002 @default.
• W2109479562 hasConceptScore W2109479562C127561419 @default.
• W2109479562 hasConceptScore W2109479562C134018914 @default.
• W2109479562 hasConceptScore W2109479562C170493617 @default.

• next