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• W2109488901 abstract "Abstract Copper chalcogenides have been demonstrated to be a promising photothermal agent due to their high photothermal conversion efficiency, synthetic simplicity, and low cost. However, the hydrophobic and less biocompatible characteristics associated with their synthetic processes hamper widely biological applications. An alternative strategy for improving hydrophilicity and biocompatibility is to coat the copper chalcogenide nanomaterials with silica shell. Herein, the rational preparation design results in successful coating mesoporous silica (mSiO 2 ) on as‐synthesized Cu 9 S 5 nanocrystals, forming Cu 9 S 5 @mSiO 2 ‐PEG core‐shell nanostructures. As‐prepared Cu 9 S 5 @mSiO 2 ‐PEG core‐shell nanostructures show low cytotoxicity and excellent blood compatibility, and are effectively employed for photothermal ablation of cancer cells and infrared thermal imaging. Moreover, anticancer drug of doxorubicin (DOX)‐loaded Cu 9 S 5 @mSiO 2 ‐PEG core‐shell nanostructures show pH sensitive release profile and are therefore beneficial to delivery of DOX into cancer cells for chemotherapy. Importantly, the combination of photothermal‐ and chemotherapies demonstrates better effects of therapy on cancer treatment than individual therapy approaches in vitro and in vivo." @default.
• W2109488901 created "2016-06-24" @default.
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• W2109488901 date "2013-04-09" @default.
• W2109488901 modified "2023-10-17" @default.
• W2109488901 title "A Low-Toxic Multifunctional Nanoplatform Based on Cu₉S₅@mSiO₂Core-Shell Nanocomposites: Combining Photothermal- and Chemotherapies with Infrared Thermal Imaging for Cancer Treatment" @default.
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• W2109488901 doi "https://doi.org/10.1002/adfm.201203317" @default.
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