FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2109489321> ?p ?o ?g. }

• W2109489321 endingPage "188" @default.
• W2109489321 startingPage "183" @default.
• W2109489321 abstract "G proteins consist of three subunits: alpha, beta and gamma. Four beta subunits have been cloned: beta 1 and beta 4 (36 kDa), and beta 2 and beta 3 (35 kDa). We studied endogenous beta subunits in mouse NIH 3T3 fibroblasts stably expressing high levels of G protein alpha subunits after transfection with cDNAs encoding alpha i1, alpha i2, alpha i3 and alpha q. Immunoblots showed that NIH 3T3 cells express beta 36 and beta 35 subunits; in these cells, beta 35 subunits are four times more abundant than beta 36 subunits. We could detect beta 1 and beta 2 mRNA, but neither beta 3 nor beta 4 mRNA. We found that a stable increase in expression of wild-type alpha i1, alpha i2, alpha i3 or alpha q subunits is always accompanied by an increase in beta 1 and beta 2 mRNA and protein levels. There was no evidence of selectivity for an increase in beta 1 rather than beta 2 subunits depending on the type of alpha subunit overexpressed. However, constitutive activation or inactivation of alpha subunits induced specific changes in beta subunits. Expression of constitutively inactivated alpha i2 subunits was accompanied by an increase in mRNA and protein levels of both beta subunits. In contrast, cells expressing constitutively activated alpha i2 subunits did not show any change in the amount of beta proteins expressed in membranes, despite a significant increase in beta 1 and beta 2 mRNA. We conclude that stable changes in the levels of expression or degree of activation of G alpha subunits affect the level of expression, and possibly the turn-over, of beta subunits, without selectivity among beta 1 and beta 2 subunits." @default.
• W2109489321 created "2016-06-24" @default.
• W2109489321 creator A5004120768 @default.
• W2109489321 creator A5056157634 @default.
• W2109489321 creator A5076006402 @default.
• W2109489321 date "1993-07-26" @default.
• W2109489321 modified "2023-09-25" @default.
• W2109489321 title "Stable changes in expression or activation of G protein α_ior α_qsubunits affect the expression of both β₁and β₂subunits" @default.
• W2109489321 cites W1482911857 @default.
• W2109489321 cites W1483151675 @default.
• W2109489321 cites W1499460529 @default.
• W2109489321 cites W1505155297 @default.
• W2109489321 cites W1513857523 @default.
• W2109489321 cites W1516430041 @default.
• W2109489321 cites W1520390436 @default.
• W2109489321 cites W1522080250 @default.
• W2109489321 cites W1522965874 @default.
• W2109489321 cites W1532095908 @default.
• W2109489321 cites W1535774104 @default.
• W2109489321 cites W1536363529 @default.
• W2109489321 cites W1538753633 @default.
• W2109489321 cites W1539355634 @default.
• W2109489321 cites W1543221735 @default.
• W2109489321 cites W1555368961 @default.
• W2109489321 cites W1568965788 @default.
• W2109489321 cites W1580968401 @default.
• W2109489321 cites W1589424070 @default.
• W2109489321 cites W1590423596 @default.
• W2109489321 cites W1597849822 @default.
• W2109489321 cites W1604214492 @default.
• W2109489321 cites W1604834232 @default.
• W2109489321 cites W1626322384 @default.
• W2109489321 cites W1681740130 @default.
• W2109489321 cites W1927136327 @default.
• W2109489321 cites W1969583788 @default.
• W2109489321 cites W1970435627 @default.
• W2109489321 cites W1972383232 @default.
• W2109489321 cites W1972760976 @default.
• W2109489321 cites W1973613428 @default.
• W2109489321 cites W1975048596 @default.
• W2109489321 cites W1975614725 @default.
• W2109489321 cites W1977598234 @default.
• W2109489321 cites W1977643695 @default.
• W2109489321 cites W2000115325 @default.
• W2109489321 cites W2005189737 @default.
• W2109489321 cites W202512738 @default.
• W2109489321 cites W2036111975 @default.
• W2109489321 cites W2037618495 @default.
• W2109489321 cites W2038993552 @default.
• W2109489321 cites W2039286502 @default.
• W2109489321 cites W2039777099 @default.
• W2109489321 cites W2065664139 @default.
• W2109489321 cites W2084287390 @default.
• W2109489321 cites W2089627071 @default.
• W2109489321 cites W2093129636 @default.
• W2109489321 cites W2134398236 @default.
• W2109489321 cites W2173886481 @default.
• W2109489321 cites W2281377962 @default.
• W2109489321 cites W33337913 @default.
• W2109489321 cites W33975413 @default.
• W2109489321 cites W4293247451 @default.
• W2109489321 doi "https://doi.org/10.1016/0014-5793(93)80166-r" @default.
• W2109489321 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8335108" @default.
• W2109489321 hasPublicationYear "1993" @default.
• W2109489321 type Work @default.
• W2109489321 sameAs 2109489321 @default.
• W2109489321 citedByCount "14" @default.
• W2109489321 crossrefType "journal-article" @default.
• W2109489321 hasAuthorship W2109489321A5004120768 @default.
• W2109489321 hasAuthorship W2109489321A5056157634 @default.
• W2109489321 hasAuthorship W2109489321A5076006402 @default.
• W2109489321 hasConcept C104292427 @default.
• W2109489321 hasConcept C104317684 @default.
• W2109489321 hasConcept C105580179 @default.
• W2109489321 hasConcept C111798993 @default.
• W2109489321 hasConcept C121608353 @default.
• W2109489321 hasConcept C150194340 @default.
• W2109489321 hasConcept C153911025 @default.
• W2109489321 hasConcept C159110408 @default.
• W2109489321 hasConcept C164083038 @default.
• W2109489321 hasConcept C185592680 @default.
• W2109489321 hasConcept C199360897 @default.
• W2109489321 hasConcept C2775944032 @default.
• W2109489321 hasConcept C2776174256 @default.
• W2109489321 hasConcept C41008148 @default.
• W2109489321 hasConcept C49453240 @default.
• W2109489321 hasConcept C54009773 @default.
• W2109489321 hasConcept C54355233 @default.
• W2109489321 hasConcept C55493867 @default.
• W2109489321 hasConcept C62478195 @default.
• W2109489321 hasConcept C64943373 @default.
• W2109489321 hasConcept C71924100 @default.
• W2109489321 hasConcept C80631254 @default.
• W2109489321 hasConcept C83730767 @default.
• W2109489321 hasConcept C86803240 @default.
• W2109489321 hasConcept C95444343 @default.
• W2109489321 hasConceptScore W2109489321C104292427 @default.
• W2109489321 hasConceptScore W2109489321C104317684 @default.

• next