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- W2109494273 abstract "The major histocompatibility complex (MHC) is a multi-gene family unique to the vertebrates, whose products function to present peptides to T cells. Certain MHC loci are highly polymorphic, and this polymorphism is maintained by a form of balancing selection, probably overdominant selection. This selection has several consequences for MHC biology that make these genes different from neutrally evolving genes: an enhanced rate of nonsynonymous nucleotide substitution in codons encoding the peptide-binding region; long-lasting (trans-species) polymorphism; and homogenization of introns relative to exons as a result of recombination and subsequent genetic drift. The MHC also reveals evidence of processes shared with other multi-gene families, including gene duplication and deletion and a low level of inter-locus recombination." @default.
- W2109494273 created "2016-06-24" @default.
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- W2109494273 date "1998-01-01" @default.
- W2109494273 modified "2023-10-13" @default.
- W2109494273 title "Natural selection and the evolutionary history of major histocompatibility complex loci" @default.
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- W2109494273 doi "https://doi.org/10.2741/a298" @default.
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