Matches in SemOpenAlex for { <https://semopenalex.org/work/W2109495864> ?p ?o ?g. }
- W2109495864 endingPage "521" @default.
- W2109495864 startingPage "497" @default.
- W2109495864 abstract "Elevation of intracellular free Ca(2+) is one of the key triggering signals for T-cell activation by antigen. A remarkable variety of Ca(2+) signals in T cells, ranging from infrequent spikes to sustained oscillations and plateaus, derives from the interactions of multiple Ca(2+) sources and sinks in the cell. Following engagement of the T cell receptor, intracellular channels (IP3 and ryanodine receptors) release Ca(2+) from intracellular stores, and by depleting the stores trigger prolonged Ca(2+) influx through store-operated Ca(2+) (CRAC) channels in the plasma membrane. The amplitude and dynamics of the Ca(2+) signal are shaped by several mechanisms, including K(+) channels and membrane potential, slow modulation of the plasma membrane Ca(2+)-ATPase, and mitochondria that buffer Ca(2+) and prevent the inactivation of CRAC channels. Ca(2+) signals have a number of downstream targets occurring on multiple time scales. At short times, Ca(2+) signals help to stabilize contacts between T cells and antigen-presenting cells through changes in motility and cytoskeletal reorganization. Over periods of minutes to hours, the amplitude, duration, and kinetic signature of Ca(2+) signals increase the efficiency and specificity of gene activation events. The complexity of Ca(2+) signals contains a wealth of information that may help to instruct lymphocytes to choose between alternate fates in response to antigenic stimulation." @default.
- W2109495864 created "2016-06-24" @default.
- W2109495864 creator A5079895950 @default.
- W2109495864 date "2001-04-01" @default.
- W2109495864 modified "2023-10-16" @default.
- W2109495864 title "Calcium Signaling Mechanisms in T Lymphocytes" @default.
- W2109495864 cites W1488869774 @default.
- W2109495864 cites W1490720426 @default.
- W2109495864 cites W1497010214 @default.
- W2109495864 cites W1498070030 @default.
- W2109495864 cites W150246076 @default.
- W2109495864 cites W1532560676 @default.
- W2109495864 cites W1545530671 @default.
- W2109495864 cites W1547874256 @default.
- W2109495864 cites W1550326988 @default.
- W2109495864 cites W1573590097 @default.
- W2109495864 cites W1650401181 @default.
- W2109495864 cites W1661761832 @default.
- W2109495864 cites W1666469474 @default.
- W2109495864 cites W1676495195 @default.
- W2109495864 cites W1678757150 @default.
- W2109495864 cites W1784820495 @default.
- W2109495864 cites W1792354214 @default.
- W2109495864 cites W1800193450 @default.
- W2109495864 cites W1857056367 @default.
- W2109495864 cites W1874327812 @default.
- W2109495864 cites W1910853730 @default.
- W2109495864 cites W1966008657 @default.
- W2109495864 cites W1973217384 @default.
- W2109495864 cites W1974125844 @default.
- W2109495864 cites W1974342767 @default.
- W2109495864 cites W1974958457 @default.
- W2109495864 cites W1977326579 @default.
- W2109495864 cites W1977461643 @default.
- W2109495864 cites W1980166477 @default.
- W2109495864 cites W1981052367 @default.
- W2109495864 cites W1981070246 @default.
- W2109495864 cites W1983672484 @default.
- W2109495864 cites W1985086376 @default.
- W2109495864 cites W1986801182 @default.
- W2109495864 cites W1987276980 @default.
- W2109495864 cites W1988406918 @default.
- W2109495864 cites W1990246525 @default.
- W2109495864 cites W1994948311 @default.
- W2109495864 cites W1997130768 @default.
- W2109495864 cites W1997778815 @default.
- W2109495864 cites W1997901402 @default.
- W2109495864 cites W1997903405 @default.
- W2109495864 cites W1998606603 @default.
- W2109495864 cites W2001064691 @default.
- W2109495864 cites W2002027111 @default.
- W2109495864 cites W2002391451 @default.
- W2109495864 cites W2002441736 @default.
- W2109495864 cites W2008329814 @default.
- W2109495864 cites W2009936338 @default.
- W2109495864 cites W2012302730 @default.
- W2109495864 cites W2012462160 @default.
- W2109495864 cites W2015084021 @default.
- W2109495864 cites W2015372263 @default.
- W2109495864 cites W2015480034 @default.
- W2109495864 cites W2017610520 @default.
- W2109495864 cites W2020520033 @default.
- W2109495864 cites W2021808867 @default.
- W2109495864 cites W2022873157 @default.
- W2109495864 cites W2023124110 @default.
- W2109495864 cites W2024957425 @default.
- W2109495864 cites W2025081899 @default.
- W2109495864 cites W2029716015 @default.
- W2109495864 cites W2032815192 @default.
- W2109495864 cites W2033128474 @default.
- W2109495864 cites W2034780161 @default.
- W2109495864 cites W2034946023 @default.
- W2109495864 cites W2035920388 @default.
- W2109495864 cites W2036521339 @default.
- W2109495864 cites W2041690080 @default.
- W2109495864 cites W2042659435 @default.
- W2109495864 cites W2042704418 @default.
- W2109495864 cites W2043477692 @default.
- W2109495864 cites W2044070752 @default.
- W2109495864 cites W2044406741 @default.
- W2109495864 cites W2046344499 @default.
- W2109495864 cites W2049525996 @default.
- W2109495864 cites W2052173175 @default.
- W2109495864 cites W2052733018 @default.
- W2109495864 cites W2053903353 @default.
- W2109495864 cites W2054736731 @default.
- W2109495864 cites W2060922168 @default.
- W2109495864 cites W2061406577 @default.
- W2109495864 cites W2066320353 @default.
- W2109495864 cites W2069358534 @default.
- W2109495864 cites W2071981946 @default.
- W2109495864 cites W2073706613 @default.
- W2109495864 cites W2075105177 @default.
- W2109495864 cites W2076171916 @default.
- W2109495864 cites W2076882136 @default.
- W2109495864 cites W2078254067 @default.
- W2109495864 cites W2078663076 @default.
- W2109495864 cites W2080312195 @default.