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- W2109506765 abstract "Interleukin-12 (IL-12), a heterodimeric cytokine produced by activated monocytes and dendritic cells, plays a crucial role in regulating interferon (IFN)-gamma production and in the generation of IFN-gamma-producing T helper 1 (Th1) cells. Here we show that the IL-12 receptor (IL-12R) beta 2 subunit, a recently cloned binding and signal transducing component of the IL-12R, is expressed on human Th1 but not Th2 clones and is induced during differentiation of human naive cells along the Th1 but not the Th2 pathway. IL-12 and type I but not type II interferons induce expression of the IL-12R beta 2 chain during in vitro T cell differentiation after antigen receptor triggering. The selective expression and regulation of the IL-12R beta 2 subunit may help to understand the basis of Th1/Th2 differentiation and may provide therapeutic options for altering the Th1/Th2 balance in several immuno-pathological conditions such as autoimmune diseases and allergies." @default.
- W2109506765 created "2016-06-24" @default.
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- W2109506765 date "1997-03-03" @default.
- W2109506765 modified "2023-09-23" @default.
- W2109506765 title "Selective Expression of an Interleukin-12 Receptor Component by Human T Helper 1 Cells" @default.
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- W2109506765 doi "https://doi.org/10.1084/jem.185.5.825" @default.
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