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- W2109512428 abstract "Drug selectivity is arguably a critical concern for drug development. Recently, experimental evidence suggests that drugs have more selectivity than that afforded by differential affinity for different receptor subtypes. Drugs, acting at a single receptor, can selectively and differentially activate each of the multiple signaling pathways coupled to a receptor. This type of selectivity has been termed functional selectivity. Understanding functional selectivity and how to measure it will be important for new drug development." @default.
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- W2109512428 date "2010-03-01" @default.
- W2109512428 modified "2023-09-26" @default.
- W2109512428 title "Use of functional assays to detect and quantify functional selectivity" @default.
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- W2109512428 doi "https://doi.org/10.1016/j.ddtec.2010.07.001" @default.
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