FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2109518992> ?p ?o ?g. }

• W2109518992 endingPage "e90953" @default.
• W2109518992 startingPage "e90953" @default.
• W2109518992 abstract "Traumatic brain injury (TBI) is associated with neuro-inflammation, debilitating sensory-motor deficits, and learning and memory impairments. Cell-based therapies are currently being investigated in treating neurotrauma due to their ability to secrete neurotrophic factors and anti-inflammatory cytokines that can regulate the hostile milieu associated with chronic neuroinflammation found in TBI. In tandem, the stimulation and mobilization of endogenous stem/progenitor cells from the bone marrow through granulocyte colony stimulating factor (G-CSF) poses as an attractive therapeutic intervention for chronic TBI. Here, we tested the potential of a combined therapy of human umbilical cord blood cells (hUCB) and G-CSF at the acute stage of TBI to counteract the progressive secondary effects of chronic TBI using the controlled cortical impact model. Four different groups of adult Sprague Dawley rats were treated with saline alone, G-CSF+saline, hUCB+saline or hUCB+G-CSF, 7-days post CCI moderate TBI. Eight weeks after TBI, brains were harvested to analyze hippocampal cell loss, neuroinflammatory response, and neurogenesis by using immunohistochemical techniques. Results revealed that the rats exposed to TBI treated with saline exhibited widespread neuroinflammation, impaired endogenous neurogenesis in DG and SVZ, and severe hippocampal cell loss. hUCB monotherapy suppressed neuroinflammation, nearly normalized the neurogenesis, and reduced hippocampal cell loss compared to saline alone. G-CSF monotherapy produced partial and short-lived benefits characterized by low levels of neuroinflammation in striatum, DG, SVZ, and corpus callosum and fornix, a modest neurogenesis, and a moderate reduction of hippocampal cells loss. On the other hand, combined therapy of hUCB+G-CSF displayed synergistic effects that robustly dampened neuroinflammation, while enhancing endogenous neurogenesis and reducing hippocampal cell loss. Vigorous and long-lasting recovery of motor function accompanied the combined therapy, which was either moderately or short-lived in the monotherapy conditions. These results suggest that combined treatment rather than monotherapy appears optimal for abrogating histophalogical and motor impairments in chronic TBI." @default.
• W2109518992 created "2016-06-24" @default.
• W2109518992 creator A5011397426 @default.
• W2109518992 creator A5028208209 @default.
• W2109518992 creator A5034078953 @default.
• W2109518992 creator A5034214932 @default.
• W2109518992 creator A5035194870 @default.
• W2109518992 creator A5040987312 @default.
• W2109518992 creator A5042051550 @default.
• W2109518992 creator A5051270572 @default.
• W2109518992 creator A5070377660 @default.
• W2109518992 date "2014-03-12" @default.
• W2109518992 modified "2023-10-11" @default.
• W2109518992 title "Combination Therapy of Human Umbilical Cord Blood Cells and Granulocyte Colony Stimulating Factor Reduces Histopathological and Motor Impairments in an Experimental Model of Chronic Traumatic Brain Injury" @default.
• W2109518992 cites W1522851953 @default.
• W2109518992 cites W1557671060 @default.
• W2109518992 cites W1571180269 @default.
• W2109518992 cites W1578543970 @default.
• W2109518992 cites W1874985344 @default.
• W2109518992 cites W1966308623 @default.
• W2109518992 cites W1968279831 @default.
• W2109518992 cites W1968343346 @default.
• W2109518992 cites W1972423968 @default.
• W2109518992 cites W1977132465 @default.
• W2109518992 cites W1978776467 @default.
• W2109518992 cites W1983300644 @default.
• W2109518992 cites W1985955413 @default.
• W2109518992 cites W1987775698 @default.
• W2109518992 cites W1988497031 @default.
• W2109518992 cites W1992514125 @default.
• W2109518992 cites W1995657434 @default.
• W2109518992 cites W1998959781 @default.
• W2109518992 cites W2001176185 @default.
• W2109518992 cites W200476470 @default.
• W2109518992 cites W2012537607 @default.
• W2109518992 cites W2012821843 @default.
• W2109518992 cites W2014648588 @default.
• W2109518992 cites W2015356290 @default.
• W2109518992 cites W2016810953 @default.
• W2109518992 cites W2019452012 @default.
• W2109518992 cites W2023656078 @default.
• W2109518992 cites W2028535633 @default.
• W2109518992 cites W2034623619 @default.
• W2109518992 cites W2035356789 @default.
• W2109518992 cites W2035812526 @default.
• W2109518992 cites W2037896141 @default.
• W2109518992 cites W2040394154 @default.
• W2109518992 cites W2043422421 @default.
• W2109518992 cites W2043427017 @default.
• W2109518992 cites W2051230113 @default.
• W2109518992 cites W2056143628 @default.
• W2109518992 cites W2059458391 @default.
• W2109518992 cites W2062419087 @default.
• W2109518992 cites W2063011477 @default.
• W2109518992 cites W2063238938 @default.
• W2109518992 cites W2065995663 @default.
• W2109518992 cites W2068112437 @default.
• W2109518992 cites W2068469528 @default.
• W2109518992 cites W2069473580 @default.
• W2109518992 cites W2075039289 @default.
• W2109518992 cites W2081215115 @default.
• W2109518992 cites W2081721257 @default.
• W2109518992 cites W2084428331 @default.
• W2109518992 cites W2084674974 @default.
• W2109518992 cites W2088350637 @default.
• W2109518992 cites W2106074632 @default.
• W2109518992 cites W2108562243 @default.
• W2109518992 cites W2112091914 @default.
• W2109518992 cites W2115059455 @default.
• W2109518992 cites W2116868957 @default.
• W2109518992 cites W2118019247 @default.
• W2109518992 cites W2120278774 @default.
• W2109518992 cites W2121703329 @default.
• W2109518992 cites W2134845552 @default.
• W2109518992 cites W2136518352 @default.
• W2109518992 cites W2137725714 @default.
• W2109518992 cites W2138019106 @default.
• W2109518992 cites W2142631525 @default.
• W2109518992 cites W2146373526 @default.
• W2109518992 cites W2148821030 @default.
• W2109518992 cites W2149781980 @default.
• W2109518992 cites W2163806130 @default.
• W2109518992 cites W2317776777 @default.
• W2109518992 cites W2318479025 @default.
• W2109518992 cites W2319339639 @default.
• W2109518992 cites W2319937456 @default.
• W2109518992 cites W2736091234 @default.
• W2109518992 cites W289221030 @default.
• W2109518992 cites W4213109870 @default.
• W2109518992 cites W4254329016 @default.
• W2109518992 cites W51545809 @default.
• W2109518992 doi "https://doi.org/10.1371/journal.pone.0090953" @default.
• W2109518992 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3951247" @default.
• W2109518992 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24621603" @default.
• W2109518992 hasPublicationYear "2014" @default.
• W2109518992 type Work @default.
• W2109518992 sameAs 2109518992 @default.
• W2109518992 citedByCount "92" @default.

• next