Matches in SemOpenAlex for { <https://semopenalex.org/work/W2109533197> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W2109533197 abstract "The effect of continuous exposure to trichloroethylene (TRI), tetrachloroethylene (TETRA) or methylchloroform (MC) on the hepatic mixed-function oxidase system (MFOS) was studied in rats by using 10 000 x g supernatant fraction. Exposure to TETRA for 240 h at 200, 100 and 50 ppm enhanced oxidative conversion from TETRA to trichloroacetic acid. When the animals were exposed for 240 h to 200, 400 and 800 ppm, oxidative conversion from MC to trichloroethanol was elevated. However, elevation was less remarkable with the increase of exposure intensities from 400 to 800 ppm. With TRI, MFOS activities were more critically assessed as a function of duration and dose because the variable response in MFOS activity was observed in preliminary studies when rats were exposed to 400 ppm for 240 h. The MFOS activities in rats exposed to TRI at 50, 400 or 800 ppm for 48 h, 72 h, 168 h and 240 h were measured. The MFOS activities were all suppressed after 48-h exposure irrespective of the exposure concentration. After 72--240 h, suppression was superseded by activation at 50 ppm, while continuity of suppressive state was observed at 800 ppm and transitional state was the case of the exposure at 400 ppm. The possibility that epoxide hydratase would be involved in the metabolism of TRI, but not in those of other two chemicals, was also presented. Based on these findings, mathematical models for TRI and TETRA metabolism were established, which can explain hepatotoxicity appearing only after exposure to TRI at 800 ppm for 168 h or more." @default.
- W2109533197 created "2016-06-24" @default.
- W2109533197 creator A5010210218 @default.
- W2109533197 creator A5041375064 @default.
- W2109533197 creator A5049632995 @default.
- W2109533197 date "1983-08-01" @default.
- W2109533197 modified "2023-10-16" @default.
- W2109533197 title "Dose-dependent induction and suppression of liver mixed-function oxidase system in chlorinated hydrocarbon solvent metabolism" @default.
- W2109533197 cites W1775749144 @default.
- W2109533197 cites W1963485685 @default.
- W2109533197 cites W1968620008 @default.
- W2109533197 cites W1972326386 @default.
- W2109533197 cites W1972707202 @default.
- W2109533197 cites W1976419674 @default.
- W2109533197 cites W1981048462 @default.
- W2109533197 cites W1981715459 @default.
- W2109533197 cites W1984713897 @default.
- W2109533197 cites W1986462930 @default.
- W2109533197 cites W1986509810 @default.
- W2109533197 cites W1993359662 @default.
- W2109533197 cites W1995591316 @default.
- W2109533197 cites W1997326207 @default.
- W2109533197 cites W1998093640 @default.
- W2109533197 cites W2000340044 @default.
- W2109533197 cites W2000955592 @default.
- W2109533197 cites W2006720511 @default.
- W2109533197 cites W2012271635 @default.
- W2109533197 cites W2036411832 @default.
- W2109533197 cites W2042218681 @default.
- W2109533197 cites W2050093726 @default.
- W2109533197 cites W2051080639 @default.
- W2109533197 cites W2056989076 @default.
- W2109533197 cites W2065462331 @default.
- W2109533197 cites W2070935815 @default.
- W2109533197 cites W2074090005 @default.
- W2109533197 cites W2077075620 @default.
- W2109533197 cites W2093629113 @default.
- W2109533197 cites W2257179091 @default.
- W2109533197 cites W2263023695 @default.
- W2109533197 cites W2321342700 @default.
- W2109533197 cites W2331927108 @default.
- W2109533197 cites W2434174817 @default.
- W2109533197 doi "https://doi.org/10.1002/jat.2550030409" @default.
- W2109533197 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6643917" @default.
- W2109533197 hasPublicationYear "1983" @default.
- W2109533197 type Work @default.
- W2109533197 sameAs 2109533197 @default.
- W2109533197 citedByCount "6" @default.
- W2109533197 crossrefType "journal-article" @default.
- W2109533197 hasAuthorship W2109533197A5010210218 @default.
- W2109533197 hasAuthorship W2109533197A5041375064 @default.
- W2109533197 hasAuthorship W2109533197A5049632995 @default.
- W2109533197 hasConcept C178790620 @default.
- W2109533197 hasConcept C185592680 @default.
- W2109533197 hasConcept C2777332483 @default.
- W2109533197 hasConcept C2779404209 @default.
- W2109533197 hasConcept C2780371127 @default.
- W2109533197 hasConcept C55493867 @default.
- W2109533197 hasConcept C57600042 @default.
- W2109533197 hasConcept C62231903 @default.
- W2109533197 hasConceptScore W2109533197C178790620 @default.
- W2109533197 hasConceptScore W2109533197C185592680 @default.
- W2109533197 hasConceptScore W2109533197C2777332483 @default.
- W2109533197 hasConceptScore W2109533197C2779404209 @default.
- W2109533197 hasConceptScore W2109533197C2780371127 @default.
- W2109533197 hasConceptScore W2109533197C55493867 @default.
- W2109533197 hasConceptScore W2109533197C57600042 @default.
- W2109533197 hasConceptScore W2109533197C62231903 @default.
- W2109533197 hasLocation W21095331971 @default.
- W2109533197 hasLocation W21095331972 @default.
- W2109533197 hasOpenAccess W2109533197 @default.
- W2109533197 hasPrimaryLocation W21095331971 @default.
- W2109533197 hasRelatedWork W1970932976 @default.
- W2109533197 hasRelatedWork W1994181408 @default.
- W2109533197 hasRelatedWork W2000955592 @default.
- W2109533197 hasRelatedWork W2005939680 @default.
- W2109533197 hasRelatedWork W2009362501 @default.
- W2109533197 hasRelatedWork W2040724991 @default.
- W2109533197 hasRelatedWork W2068483463 @default.
- W2109533197 hasRelatedWork W2071010596 @default.
- W2109533197 hasRelatedWork W2109533197 @default.
- W2109533197 hasRelatedWork W2170643058 @default.
- W2109533197 isParatext "false" @default.
- W2109533197 isRetracted "false" @default.
- W2109533197 magId "2109533197" @default.
- W2109533197 workType "article" @default.