FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2109543237> ?p ?o ?g. }

• W2109543237 endingPage "81" @default.
• W2109543237 startingPage "76" @default.
• W2109543237 abstract "Observational data strongly suggest an association between Chlamydia pneumoniae and atherosclerotic cardiovascular disease. However, few studies have mechanistically linked C. pneumoniae to vascular remodeling. The purpose of the present study was to examine the mechanistic relationship between C. pneumoniae and human vascular smooth muscle cell (VSMC) physiology. We sought to determine the influence of human VSMC infection by C. pneumoniae on (1) VSMC proliferation and (2) activation of the proinflammatory and proliferative transcription factors nuclear factor kappaB (NF-kappaB) and activator protein 1 (AP-1).C. pneumoniae was grown and isolated from Hep 2 cells. Human aortic VSMCs were inoculated with C. pneumoniae in the presence and absence of the azalide antibiotic azithromycin. Cell proliferation was assayed by direct cell counting 48 h following infection. Two hours following infection, nuclear extracts were isolated, and activation of both NF-kappaB and AP-1 was assessed by electrophoretic mobility shift assay.Compared with control, C. pneumoniae infection stimulated VSMC proliferation (P < 0.05) and induced both NF-kappaB and AP-1 DNA binding activity. These effects were eliminated by concurrent treatment with azithromycin.VSMC infection with C. pneumoniae activates proliferative intracellular signals and stimulates cell growth. These data implicate C. pneumoniae as a pathogenic mediator and a potential therapeutic target in the prevention of atherosclerotic disease." @default.
• W2109543237 created "2016-06-24" @default.
• W2109543237 creator A5014768457 @default.
• W2109543237 creator A5031493840 @default.
• W2109543237 creator A5043499587 @default.
• W2109543237 creator A5056398970 @default.
• W2109543237 creator A5060090431 @default.
• W2109543237 creator A5087253902 @default.
• W2109543237 date "2000-05-01" @default.
• W2109543237 modified "2023-09-27" @default.
• W2109543237 title "Chlamydia pneumoniae Activates Nuclear Factor κB and Activator Protein 1 in Human Vascular Smooth Muscle and Induces Cellular Proliferation" @default.
• W2109543237 cites W1572015081 @default.
• W2109543237 cites W1982072699 @default.
• W2109543237 cites W1991399431 @default.
• W2109543237 cites W1993298922 @default.
• W2109543237 cites W1994005983 @default.
• W2109543237 cites W2013504879 @default.
• W2109543237 cites W2024185310 @default.
• W2109543237 cites W2038978803 @default.
• W2109543237 cites W2047508819 @default.
• W2109543237 cites W2049138031 @default.
• W2109543237 cites W2051537874 @default.
• W2109543237 cites W2056034929 @default.
• W2109543237 cites W2061940963 @default.
• W2109543237 cites W2068743272 @default.
• W2109543237 cites W2100799773 @default.
• W2109543237 cites W2101918654 @default.
• W2109543237 cites W2116621726 @default.
• W2109543237 cites W2117490971 @default.
• W2109543237 cites W2117963156 @default.
• W2109543237 cites W2119004647 @default.
• W2109543237 cites W2152214792 @default.
• W2109543237 cites W2154244638 @default.
• W2109543237 cites W2155807420 @default.
• W2109543237 cites W2164271022 @default.
• W2109543237 cites W2166227663 @default.
• W2109543237 cites W2324841714 @default.
• W2109543237 doi "https://doi.org/10.1006/jsre.2000.5847" @default.
• W2109543237 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10781378" @default.
• W2109543237 hasPublicationYear "2000" @default.
• W2109543237 type Work @default.
• W2109543237 sameAs 2109543237 @default.
• W2109543237 citedByCount "52" @default.
• W2109543237 countsByYear W21095432372012 @default.
• W2109543237 countsByYear W21095432372013 @default.
• W2109543237 countsByYear W21095432372014 @default.
• W2109543237 countsByYear W21095432372015 @default.
• W2109543237 countsByYear W21095432372016 @default.
• W2109543237 countsByYear W21095432372018 @default.
• W2109543237 countsByYear W21095432372019 @default.
• W2109543237 countsByYear W21095432372020 @default.
• W2109543237 crossrefType "journal-article" @default.
• W2109543237 hasAuthorship W2109543237A5014768457 @default.
• W2109543237 hasAuthorship W2109543237A5031493840 @default.
• W2109543237 hasAuthorship W2109543237A5043499587 @default.
• W2109543237 hasAuthorship W2109543237A5056398970 @default.
• W2109543237 hasAuthorship W2109543237A5060090431 @default.
• W2109543237 hasAuthorship W2109543237A5087253902 @default.
• W2109543237 hasConcept C104317684 @default.
• W2109543237 hasConcept C134018914 @default.
• W2109543237 hasConcept C1491633281 @default.
• W2109543237 hasConcept C164027704 @default.
• W2109543237 hasConcept C183978625 @default.
• W2109543237 hasConcept C203014093 @default.
• W2109543237 hasConcept C2776914184 @default.
• W2109543237 hasConcept C2777038808 @default.
• W2109543237 hasConcept C2778419347 @default.
• W2109543237 hasConcept C2779395532 @default.
• W2109543237 hasConcept C2780122209 @default.
• W2109543237 hasConcept C2992686903 @default.
• W2109543237 hasConcept C55493867 @default.
• W2109543237 hasConcept C62112901 @default.
• W2109543237 hasConcept C86339819 @default.
• W2109543237 hasConcept C86803240 @default.
• W2109543237 hasConcept C89423630 @default.
• W2109543237 hasConceptScore W2109543237C104317684 @default.
• W2109543237 hasConceptScore W2109543237C134018914 @default.
• W2109543237 hasConceptScore W2109543237C1491633281 @default.
• W2109543237 hasConceptScore W2109543237C164027704 @default.
• W2109543237 hasConceptScore W2109543237C183978625 @default.
• W2109543237 hasConceptScore W2109543237C203014093 @default.
• W2109543237 hasConceptScore W2109543237C2776914184 @default.
• W2109543237 hasConceptScore W2109543237C2777038808 @default.
• W2109543237 hasConceptScore W2109543237C2778419347 @default.
• W2109543237 hasConceptScore W2109543237C2779395532 @default.
• W2109543237 hasConceptScore W2109543237C2780122209 @default.
• W2109543237 hasConceptScore W2109543237C2992686903 @default.
• W2109543237 hasConceptScore W2109543237C55493867 @default.
• W2109543237 hasConceptScore W2109543237C62112901 @default.
• W2109543237 hasConceptScore W2109543237C86339819 @default.
• W2109543237 hasConceptScore W2109543237C86803240 @default.
• W2109543237 hasConceptScore W2109543237C89423630 @default.
• W2109543237 hasIssue "1" @default.
• W2109543237 hasLocation W21095432371 @default.
• W2109543237 hasLocation W21095432372 @default.
• W2109543237 hasOpenAccess W2109543237 @default.
• W2109543237 hasPrimaryLocation W21095432371 @default.
• W2109543237 hasRelatedWork W1556305341 @default.

• next