Matches in SemOpenAlex for { <https://semopenalex.org/work/W2109550125> ?p ?o ?g. }
- W2109550125 endingPage "526" @default.
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- W2109550125 abstract "SUMMARY The arrest of DNA replication in Escherichia coli is triggered by the encounter of a replisome with a Tus protein- Ter DNA complex. A replication fork can pass through a Tus- Ter complex when traveling in one direction but not the other, and the chromosomal Ter sites are oriented so replication forks can enter, but not exit, the terminus region. The Tus- Ter complex acts by blocking the action of the replicative DnaB helicase, but details of the mechanism are uncertain. One proposed mechanism involves a specific interaction between Tus- Ter and the helicase that prevents further DNA unwinding, while another is that the Tus- Ter complex itself is sufficient to block the helicase in a polar manner, without the need for specific protein-protein interactions. This review integrates three decades of experimental information on the action of the Tus- Ter complex with information available from the Tus- TerA crystal structure. We conclude that while it is possible to explain polar fork arrest by a mechanism involving only the Tus- Ter interaction, there are also strong indications of a role for specific Tus-DnaB interactions. The evidence suggests, therefore, that the termination system is more subtle and complex than may have been assumed. We describe some further experiments and insights that may assist in unraveling the details of this fascinating process." @default.
- W2109550125 created "2016-06-24" @default.
- W2109550125 creator A5010613162 @default.
- W2109550125 creator A5011359890 @default.
- W2109550125 creator A5048552040 @default.
- W2109550125 creator A5070988583 @default.
- W2109550125 date "2005-09-01" @default.
- W2109550125 modified "2023-10-10" @default.
- W2109550125 title "Replication Termination in <i>Escherichia coli</i> : Structure and Antihelicase Activity of the Tus- <i>Ter</i> Complex" @default.
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