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• W2109553674 abstract "The object of this review has been to consider precursor cell migration into the normal adult thymus, using the mouse model. We have presented a series of experiments and discussed them in the context of other relevant experiments in the literature. The conclusions, qualified in the text, can be summarized as follows: There is a continual input of precursor cells into the normal undepleted adult thymus. The daily input of precursors under normal circumstances is very low (e.g. several per day). Once a precursor enters the pool of proliferating cells inside the thymus, its proliferation is limited to only several weeks. There is no permanent endogenous stem cell. There are a number of different precursor microenvironments in the thymus with different controls, since the kinetics of early (bone marrow-derived) and late (thymus-derived) precursors is quite different. All of these points require further analysis, and we have presented a minimal model as a basis for further experiment." @default.
• W2109553674 created "2016-06-24" @default.
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• W2109553674 date "1986-06-01" @default.
• W2109553674 modified "2023-10-03" @default.
• W2109553674 title "Dynamics of Early T Cells: Prothymocyte Migration and Proliferation in the Adult Mouse Thymus" @default.
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• W2109553674 doi "https://doi.org/10.1111/j.1600-065x.1986.tb01487.x" @default.
• W2109553674 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3525392" @default.
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