FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2109554152> ?p ?o ?g. }

• W2109554152 abstract "Cardiomyopathy is a progressive myocardial disorder. Here, we attempted to reveal the possible mechanism of cardiomyopathy at the transcription level with the roles of microRNAs (miRNAs) and transcription factors (TFs) taken into account. We firstly identified differentially expressed genes (DEGs) between cardiomyopathy patients and controls with data from the gene expression omnibus (GEO) database. DEGs were associated with the canonical pathways, molecular and cellular functions, physiological system development and function in the Ingenuity Knowledge Base by using the Ingenuity Pathway Analysis (IPA) software. TFs and miRNAs that DEGs significantly enriched were identified and a double-factor regulatory network was constructed. A total of 1,680 DEGs were identified. The DEGs were enriched for various pathways, with glucocorticoid receptor signaling as the most significant. A double-factor regulatory network was constructed, including seven TFs and two miRNAs. A subnetwork under the regulation of MEF2C and SRF was also constructed to illustrate their regulatory effects on cardiac functions. Our results may provide new understanding of cardiomyopathy and may facilitate further therapeutic studies." @default.
• W2109554152 created "2016-06-24" @default.
• W2109554152 creator A5015256862 @default.
• W2109554152 creator A5024139316 @default.
• W2109554152 creator A5033178908 @default.
• W2109554152 creator A5035689898 @default.
• W2109554152 creator A5056779096 @default.
• W2109554152 creator A5065898426 @default.
• W2109554152 creator A5085385602 @default.
• W2109554152 date "2014-10-24" @default.
• W2109554152 modified "2023-10-16" @default.
• W2109554152 title "Construction of microRNA and transcription factor regulatory network based on gene expression data in cardiomyopathy" @default.
• W2109554152 cites W1974383169 @default.
• W2109554152 cites W1998689916 @default.
• W2109554152 cites W2003696364 @default.
• W2109554152 cites W2017524046 @default.
• W2109554152 cites W2024311385 @default.
• W2109554152 cites W2040191060 @default.
• W2109554152 cites W2046146856 @default.
• W2109554152 cites W2049971658 @default.
• W2109554152 cites W2059073003 @default.
• W2109554152 cites W2071803642 @default.
• W2109554152 cites W2086763220 @default.
• W2109554152 cites W2103808259 @default.
• W2109554152 cites W2111321537 @default.
• W2109554152 cites W2116351152 @default.
• W2109554152 cites W2127451238 @default.
• W2109554152 cites W2138464439 @default.
• W2109554152 cites W2140335192 @default.
• W2109554152 cites W2149785901 @default.
• W2109554152 cites W2168809313 @default.
• W2109554152 cites W2170989872 @default.
• W2109554152 doi "https://doi.org/10.1186/s40001-014-0057-5" @default.
• W2109554152 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4231188" @default.
• W2109554152 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25338953" @default.
• W2109554152 hasPublicationYear "2014" @default.
• W2109554152 type Work @default.
• W2109554152 sameAs 2109554152 @default.
• W2109554152 citedByCount "3" @default.
• W2109554152 countsByYear W21095541522018 @default.
• W2109554152 countsByYear W21095541522019 @default.
• W2109554152 countsByYear W21095541522021 @default.
• W2109554152 crossrefType "journal-article" @default.
• W2109554152 hasAuthorship W2109554152A5015256862 @default.
• W2109554152 hasAuthorship W2109554152A5024139316 @default.
• W2109554152 hasAuthorship W2109554152A5033178908 @default.
• W2109554152 hasAuthorship W2109554152A5035689898 @default.
• W2109554152 hasAuthorship W2109554152A5056779096 @default.
• W2109554152 hasAuthorship W2109554152A5065898426 @default.
• W2109554152 hasAuthorship W2109554152A5085385602 @default.
• W2109554152 hasBestOaLocation W21095541521 @default.
• W2109554152 hasConcept C104317684 @default.
• W2109554152 hasConcept C126322002 @default.
• W2109554152 hasConcept C133425853 @default.
• W2109554152 hasConcept C145059251 @default.
• W2109554152 hasConcept C150194340 @default.
• W2109554152 hasConcept C162324750 @default.
• W2109554152 hasConcept C165864922 @default.
• W2109554152 hasConcept C18431079 @default.
• W2109554152 hasConcept C2778154381 @default.
• W2109554152 hasConcept C2778198053 @default.
• W2109554152 hasConcept C2778797674 @default.
• W2109554152 hasConcept C54355233 @default.
• W2109554152 hasConcept C60644358 @default.
• W2109554152 hasConcept C67339327 @default.
• W2109554152 hasConcept C70721500 @default.
• W2109554152 hasConcept C71924100 @default.
• W2109554152 hasConcept C86339819 @default.
• W2109554152 hasConcept C86803240 @default.
• W2109554152 hasConceptScore W2109554152C104317684 @default.
• W2109554152 hasConceptScore W2109554152C126322002 @default.
• W2109554152 hasConceptScore W2109554152C133425853 @default.
• W2109554152 hasConceptScore W2109554152C145059251 @default.
• W2109554152 hasConceptScore W2109554152C150194340 @default.
• W2109554152 hasConceptScore W2109554152C162324750 @default.
• W2109554152 hasConceptScore W2109554152C165864922 @default.
• W2109554152 hasConceptScore W2109554152C18431079 @default.
• W2109554152 hasConceptScore W2109554152C2778154381 @default.
• W2109554152 hasConceptScore W2109554152C2778198053 @default.
• W2109554152 hasConceptScore W2109554152C2778797674 @default.
• W2109554152 hasConceptScore W2109554152C54355233 @default.
• W2109554152 hasConceptScore W2109554152C60644358 @default.
• W2109554152 hasConceptScore W2109554152C67339327 @default.
• W2109554152 hasConceptScore W2109554152C70721500 @default.
• W2109554152 hasConceptScore W2109554152C71924100 @default.
• W2109554152 hasConceptScore W2109554152C86339819 @default.
• W2109554152 hasConceptScore W2109554152C86803240 @default.
• W2109554152 hasIssue "1" @default.
• W2109554152 hasLocation W21095541521 @default.
• W2109554152 hasLocation W21095541522 @default.
• W2109554152 hasLocation W21095541523 @default.
• W2109554152 hasLocation W21095541524 @default.
• W2109554152 hasOpenAccess W2109554152 @default.
• W2109554152 hasPrimaryLocation W21095541521 @default.
• W2109554152 hasRelatedWork W166274801 @default.
• W2109554152 hasRelatedWork W1931096584 @default.
• W2109554152 hasRelatedWork W1971166208 @default.
• W2109554152 hasRelatedWork W1988455047 @default.
• W2109554152 hasRelatedWork W2053702430 @default.
• W2109554152 hasRelatedWork W2121796038 @default.

• next