FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2109556517> ?p ?o ?g. }

• W2109556517 endingPage "387" @default.
• W2109556517 startingPage "384" @default.
• W2109556517 abstract "Magnesium sulfate has been shown to have a bronchodilating effect in asthma, but this effect has not been clearly established in the context of chronic obstructive pulmonary disease (COPD). For this reason we investigated the possible bronchodilating effect of magnesium sulfate in COPD exacerbations. We studied 24 patients with exacerbated COPD who required admission to our hospital's pneumology department. All patients underwent baseline spirometry and were subsequently randomized to groups in a double-blind crossover design. Patients received 1.5 g of magnesium sulfate or placebo in an intravenous solution for 20 minutes. Those who received magnesium sulfate the first day were given placebo the second day, and vice versa. Spirometry was performed 15, 30, and 45 minutes after administration of magnesium sulfate or placebo. Finally, 400 μg of salbutamol were administered using a spacer and a final spirometry was performed 15 minutes later. All patients also received treatment with corticosteroids, intravenous antibiotics, oxygen, and regularly-scheduled bronchodilator therapy (salbutamol and ipratropium bromide every 6 hours). When we compared absolute increase in liters and percentage increase in forced expiratory volume in 1 second (FEV1) obtained with magnesium sulfate application to the increases obtained with placebo after 15, 30, and 45 minutes, no significant differences were found. When we compared absolute and percentage increases in FEV1 after administering salbutamol, we found significantly greater increases after magnesium sulfate administration. The mean (SD) absolute increase in FEV1 was 0.185 (0.42) L after magnesium sulfate administration and 0.081 (0.01) L after placebo (P=.004). The percentage increase in FEV1 was 17.11% (3.7%) after magnesium sulfate and 7.06% (1.8%) after placebo (P=.008). Intravenous administration of magnesium sulfate has no bronchodilating effect in patients with COPD exacerbations. It does, however, enhance the bronchodilating effect of inhaled β2-agonists. El sulfato de magnesio (SM) ha demostrado tener en el asma bronquial un efecto broncodilatador, que resulta dudoso en el caso de la enfermedad pulmonar obstructiva crónica (EPOC). Por ello hemos llevado a cabo un estudio con el objetivo de investigar el posible efecto broncodilatador del SM intravenoso en la EPOC agudizada. Se estudió a 24 pacientes diagnosticados de EPOC agudizada que requirieron ingreso en la Unidad de Hospitalizaciön de Neumología. A cada uno se le realizó una espirometría basal. Posteriormente, se efectuó una aleatorización a doble ciego y cruzada de los pacientes para recibir 1,5 g de SM o placebo en solución intravenosa (20 min). A quienes el primer día recibieron SM se les administró placebo el segundo día, y al revés. Se realizaron espirometrías a los 15, 30 y 45 min de la administración de SM o placebo. Por último, se administraron 400 μg de salbutamol inhalados mediante cámara espaciadora y a los 15 min se realizó una última espirometría. Todos los enfermos recibieron además tratamiento con esteroides, antibióticos intravenosos, oxígeno y broncodilatadores pautados (salbutamol y bromuro de ipratropio cada 6 h). Cuando se compararon los incrementos absolutes (en ml) y porcentuales del volumen espiratorio forzado en el primer segundo (FEV1) obtenidos con SM y placebo a los 15, 30 y 45 min, no se encontraron diferencias significativas. Al comparar los incrementos absolutos y porcentuales del FEV1 tras la administración de salbutamol se observaron incrementos significativos con el SM (incrementos absolutos FEV1 SM/placebo: 0,185 ± 0,42 frente a 0,081 ± 0,01 l; p = 0,004. Incrementos porcentuales FEV1 SM/placebo: 17,11 ± 3,7% frente al 7,06 ± 1,8%; p = 0,008). La administración de SM intravenoso carece de efecto broncodilatador en pacientes con EPOC agudizada; sin embargo, sí potencia dicho efecto de los betamiméticos inhalados." @default.
• W2109556517 created "2016-06-24" @default.
• W2109556517 creator A5015626780 @default.
• W2109556517 creator A5039203636 @default.
• W2109556517 creator A5051287650 @default.
• W2109556517 creator A5066628272 @default.
• W2109556517 creator A5085735401 @default.
• W2109556517 date "2006-08-01" @default.
• W2109556517 modified "2023-10-09" @default.
• W2109556517 title "Effect of Intravenous Magnesium Sulfate on Chronic Obstructive Pulmonary Disease Exacerbations Requiring Hospitalization: a Randomized Placebo-Controlled Trial" @default.
• W2109556517 cites W1979034703 @default.
• W2109556517 cites W1999187491 @default.
• W2109556517 cites W2010200788 @default.
• W2109556517 cites W2015741852 @default.
• W2109556517 cites W2030845834 @default.
• W2109556517 cites W2037296238 @default.
• W2109556517 cites W2039907207 @default.
• W2109556517 cites W2045616259 @default.
• W2109556517 cites W2072061410 @default.
• W2109556517 cites W2085281837 @default.
• W2109556517 cites W2090578166 @default.
• W2109556517 cites W2117802602 @default.
• W2109556517 cites W2126508434 @default.
• W2109556517 cites W2132172131 @default.
• W2109556517 cites W2150508175 @default.
• W2109556517 cites W2155395559 @default.
• W2109556517 cites W4250641496 @default.
• W2109556517 doi "https://doi.org/10.1016/s1579-2129(06)60551-x" @default.
• W2109556517 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16948990" @default.
• W2109556517 hasPublicationYear "2006" @default.
• W2109556517 type Work @default.
• W2109556517 sameAs 2109556517 @default.
• W2109556517 citedByCount "15" @default.
• W2109556517 countsByYear W21095565172012 @default.
• W2109556517 countsByYear W21095565172013 @default.
• W2109556517 countsByYear W21095565172014 @default.
• W2109556517 countsByYear W21095565172018 @default.
• W2109556517 countsByYear W21095565172020 @default.
• W2109556517 countsByYear W21095565172021 @default.
• W2109556517 countsByYear W21095565172022 @default.
• W2109556517 crossrefType "journal-article" @default.
• W2109556517 hasAuthorship W2109556517A5015626780 @default.
• W2109556517 hasAuthorship W2109556517A5039203636 @default.
• W2109556517 hasAuthorship W2109556517A5051287650 @default.
• W2109556517 hasAuthorship W2109556517A5066628272 @default.
• W2109556517 hasAuthorship W2109556517A5085735401 @default.
• W2109556517 hasConcept C126322002 @default.
• W2109556517 hasConcept C142724271 @default.
• W2109556517 hasConcept C191897082 @default.
• W2109556517 hasConcept C192562407 @default.
• W2109556517 hasConcept C204787440 @default.
• W2109556517 hasConcept C27081682 @default.
• W2109556517 hasConcept C2776042228 @default.
• W2109556517 hasConcept C2776780178 @default.
• W2109556517 hasConcept C2777394947 @default.
• W2109556517 hasConcept C2780333948 @default.
• W2109556517 hasConcept C2780532441 @default.
• W2109556517 hasConcept C2781018748 @default.
• W2109556517 hasConcept C42219234 @default.
• W2109556517 hasConcept C543218039 @default.
• W2109556517 hasConcept C71924100 @default.
• W2109556517 hasConcept C87813604 @default.
• W2109556517 hasConceptScore W2109556517C126322002 @default.
• W2109556517 hasConceptScore W2109556517C142724271 @default.
• W2109556517 hasConceptScore W2109556517C191897082 @default.
• W2109556517 hasConceptScore W2109556517C192562407 @default.
• W2109556517 hasConceptScore W2109556517C204787440 @default.
• W2109556517 hasConceptScore W2109556517C27081682 @default.
• W2109556517 hasConceptScore W2109556517C2776042228 @default.
• W2109556517 hasConceptScore W2109556517C2776780178 @default.
• W2109556517 hasConceptScore W2109556517C2777394947 @default.
• W2109556517 hasConceptScore W2109556517C2780333948 @default.
• W2109556517 hasConceptScore W2109556517C2780532441 @default.
• W2109556517 hasConceptScore W2109556517C2781018748 @default.
• W2109556517 hasConceptScore W2109556517C42219234 @default.
• W2109556517 hasConceptScore W2109556517C543218039 @default.
• W2109556517 hasConceptScore W2109556517C71924100 @default.
• W2109556517 hasConceptScore W2109556517C87813604 @default.
• W2109556517 hasIssue "8" @default.
• W2109556517 hasLocation W21095565171 @default.
• W2109556517 hasLocation W21095565172 @default.
• W2109556517 hasOpenAccess W2109556517 @default.
• W2109556517 hasPrimaryLocation W21095565171 @default.
• W2109556517 hasRelatedWork W1805916934 @default.
• W2109556517 hasRelatedWork W1983057355 @default.
• W2109556517 hasRelatedWork W1985443477 @default.
• W2109556517 hasRelatedWork W2049002202 @default.
• W2109556517 hasRelatedWork W2122208178 @default.
• W2109556517 hasRelatedWork W2151514597 @default.
• W2109556517 hasRelatedWork W2252156554 @default.
• W2109556517 hasRelatedWork W2344999173 @default.
• W2109556517 hasRelatedWork W3100629524 @default.
• W2109556517 hasRelatedWork W2038745812 @default.
• W2109556517 hasVolume "42" @default.
• W2109556517 isParatext "false" @default.
• W2109556517 isRetracted "false" @default.
• W2109556517 magId "2109556517" @default.
• W2109556517 workType "article" @default.