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- W2109557071 endingPage "R57" @default.
- W2109557071 startingPage "R47" @default.
- W2109557071 abstract "Thyroid hormones are important modulators of lipid metabolism because the liver is a primary hormonal target. The hypolipidaemic effects of thyroid hormones result from the balance between direct and indirect actions resulting in stimulation of lipid synthesis and lipid oxidation, which favours degradation pathways. Originally, it was believed that thyroid hormone activity was only transduced by alteration of gene transcription mediated by the nuclear receptor thyroid hormone receptors, comprising the classic action of thyroid hormone. However, the discovery of other effects independent of this classic mechanism characterised a new model of thyroid hormone action, the non-classic mechanism that involves other signalling pathways. To date, this mechanism and its relevance have been intensively described. Considering the increasing evidence for non-classic signalling of thyroid hormones and the major influence of these hormones in the regulation of lipid metabolism, we reviewed the role of thyroid hormone in cytosolic signalling cascades, focusing on the regulation of second messengers, and the activity of effector proteins and the implication of these mechanisms on the control of hepatic lipid metabolism." @default.
- W2109557071 created "2016-06-24" @default.
- W2109557071 creator A5004829143 @default.
- W2109557071 creator A5064049275 @default.
- W2109557071 creator A5074572123 @default.
- W2109557071 creator A5085579132 @default.
- W2109557071 date "2013-01-07" @default.
- W2109557071 modified "2023-10-12" @default.
- W2109557071 title "Non-classic thyroid hormone signalling involved in hepatic lipid metabolism" @default.
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