FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2109557452> ?p ?o ?g. }

• W2109557452 endingPage "408" @default.
• W2109557452 startingPage "399" @default.
• W2109557452 abstract "To provide an update on the recent knowledge about the molecular mechanisms of thermal radiosensitization and its possible relevance to thermoradiotherapy.Hyperthermia is probably the most potent cellular radiosensitizer known to date. Heat interacts with radiation and potentiates the cellular action of radiation by interfering with the cells' capability to deal with radiation-induced DNA damage. For ionizing irradiation, heat inhibits the repair of all types of DNA damage. Genetic and biochemical data suggest that the main pathways for DNA double-strand break (DSB) rejoining, non-homologous end-joining and homologous recombination, are not the likely primary targets for heat-induced radiosensitization. Rather, heat is suggested to affect primarily the religation step of base excision repair. Subsequently additional DSB arise during the DNA repair process in irradiated and heated cells and these additional DSB are all repaired with slow kinetics, the repair of which is highly error prone. Both mis- and non-rejoined DSB lead to an elevated number of lethal chromosome aberrations, finally causing additional cell killing. Heat-induced inhibition of DNA repair is considered not to result from altered signalling or enzyme inactivation but rather from alterations in higher-order chromatin structure. Although, the detailed mechanisms are not yet known, a substantial body of indirect and correlative data suggests that heat-induced protein aggregation at the level of attachment of looped DNA to the nuclear matrix impairs the accessibility of the damaged DNA for the repair machinery or impairs the processivity of the repair machinery itself.Since recent phase III clinical trials have shown significant benefit of adding hyperthermia to radiotherapy regimens for a number of malignancies, it will become more important again to determine the molecular effects underlying this success. Such information could eventually also improve treatment quality in terms of patient selection, improved sequencing of the heat and radiation treatments, the number of heat treatments, and multimodality treatments (i.e. thermochemoradiotherapy)." @default.
• W2109557452 created "2016-06-24" @default.
• W2109557452 creator A5042480102 @default.
• W2109557452 creator A5088659570 @default.
• W2109557452 date "2001-01-01" @default.
• W2109557452 modified "2023-10-11" @default.
• W2109557452 title "Hyperthermic radiosensitization: mode of action and clinical relevance" @default.
• W2109557452 cites W111348958 @default.
• W2109557452 cites W1594634968 @default.
• W2109557452 cites W1606480463 @default.
• W2109557452 cites W167027689 @default.
• W2109557452 cites W1965119945 @default.
• W2109557452 cites W1968978297 @default.
• W2109557452 cites W1973376648 @default.
• W2109557452 cites W1977639464 @default.
• W2109557452 cites W1978338221 @default.
• W2109557452 cites W1991261610 @default.
• W2109557452 cites W1993131194 @default.
• W2109557452 cites W1998444211 @default.
• W2109557452 cites W2004498595 @default.
• W2109557452 cites W2005577987 @default.
• W2109557452 cites W2009347702 @default.
• W2109557452 cites W2011121831 @default.
• W2109557452 cites W2012905336 @default.
• W2109557452 cites W2014102652 @default.
• W2109557452 cites W2014292295 @default.
• W2109557452 cites W2018336477 @default.
• W2109557452 cites W2019072372 @default.
• W2109557452 cites W2020942783 @default.
• W2109557452 cites W2023123017 @default.
• W2109557452 cites W2025633723 @default.
• W2109557452 cites W2026295838 @default.
• W2109557452 cites W2030403855 @default.
• W2109557452 cites W2043361493 @default.
• W2109557452 cites W2044217649 @default.
• W2109557452 cites W2044660908 @default.
• W2109557452 cites W2049107177 @default.
• W2109557452 cites W2051108894 @default.
• W2109557452 cites W2051662191 @default.
• W2109557452 cites W2051883249 @default.
• W2109557452 cites W2053599408 @default.
• W2109557452 cites W2054320384 @default.
• W2109557452 cites W2055863652 @default.
• W2109557452 cites W2058059616 @default.
• W2109557452 cites W2058496249 @default.
• W2109557452 cites W2058664192 @default.
• W2109557452 cites W2074220215 @default.
• W2109557452 cites W2079239443 @default.
• W2109557452 cites W2079378262 @default.
• W2109557452 cites W2081488185 @default.
• W2109557452 cites W2085083586 @default.
• W2109557452 cites W2085486779 @default.
• W2109557452 cites W2093753955 @default.
• W2109557452 cites W2094557766 @default.
• W2109557452 cites W2095079660 @default.
• W2109557452 cites W2095493818 @default.
• W2109557452 cites W2097113830 @default.
• W2109557452 cites W2102918542 @default.
• W2109557452 cites W2107716225 @default.
• W2109557452 cites W2108672624 @default.
• W2109557452 cites W2119870561 @default.
• W2109557452 cites W2120739937 @default.
• W2109557452 cites W2121015472 @default.
• W2109557452 cites W2121649591 @default.
• W2109557452 cites W2124488747 @default.
• W2109557452 cites W2125111752 @default.
• W2109557452 cites W2125941146 @default.
• W2109557452 cites W2126075789 @default.
• W2109557452 cites W2127136618 @default.
• W2109557452 cites W2133222493 @default.
• W2109557452 cites W2133323814 @default.
• W2109557452 cites W2139554694 @default.
• W2109557452 cites W2149779498 @default.
• W2109557452 cites W2154935750 @default.
• W2109557452 cites W2160307554 @default.
• W2109557452 cites W2160964257 @default.
• W2109557452 cites W2200693602 @default.
• W2109557452 cites W2202229501 @default.
• W2109557452 cites W2205097170 @default.
• W2109557452 cites W2209539339 @default.
• W2109557452 cites W2312272078 @default.
• W2109557452 cites W2313815839 @default.
• W2109557452 cites W2314753133 @default.
• W2109557452 cites W2317066100 @default.
• W2109557452 cites W2318429450 @default.
• W2109557452 cites W2324597012 @default.
• W2109557452 cites W2325461696 @default.
• W2109557452 cites W2328854054 @default.
• W2109557452 cites W2335166875 @default.
• W2109557452 cites W2335252342 @default.
• W2109557452 cites W2399572253 @default.
• W2109557452 cites W2403197275 @default.
• W2109557452 cites W2409137666 @default.
• W2109557452 cites W2489895818 @default.
• W2109557452 cites W2582428211 @default.
• W2109557452 cites W272782973 @default.
• W2109557452 cites W63437345 @default.
• W2109557452 cites W1993959306 @default.

• next