FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2109558456> ?p ?o ?g. }

• W2109558456 endingPage "5615" @default.
• W2109558456 startingPage "5610" @default.
• W2109558456 abstract "The glycogen synthase kinase 3 (GSK-3) is implicated in multiple cellular processes and has been linked to the pathogenesis of Alzheimer’s disease (AD). In the course of our research topic we synthesized a library of potent GSK-3 inhibitors. We utilized the urea scaffold present in the potent and highly selective GSK-3 inhibitor AR-A014418 (AstraZeneca). This moiety suits both (a) a convergent approach utilizing readily accessible building blocks and (b) a divergent approach based on a microwave heating assisted Suzuki coupling. We established a chromatography-free purification method to generate products with sufficient purity for the biological assays. The structure–activity relationship of the library provided the rationale for the synthesis of the benzothiazolylurea 66 (IC 50 = 140 nM) and the pyridylurea 62 (IC 50 = 98 nM), which displayed two to threefold enhanced activity versus the reference compound 18 (AR-A014418: IC 50 = 330 nM) in our assays." @default.
• W2109558456 created "2016-06-24" @default.
• W2109558456 creator A5004159421 @default.
• W2109558456 creator A5005778914 @default.
• W2109558456 creator A5026635178 @default.
• W2109558456 creator A5048371616 @default.
• W2109558456 creator A5050360058 @default.
• W2109558456 creator A5058986690 @default.
• W2109558456 creator A5073598703 @default.
• W2109558456 creator A5085908396 @default.
• W2109558456 date "2011-09-01" @default.
• W2109558456 modified "2023-10-11" @default.
• W2109558456 title "Synthesis and biological evaluation of glycogen synthase kinase 3 (GSK-3) inhibitors: An fast and atom efficient access to 1-aryl-3-benzylureas" @default.
• W2109558456 cites W1496294957 @default.
• W2109558456 cites W1577837690 @default.
• W2109558456 cites W1966757223 @default.
• W2109558456 cites W1970381834 @default.
• W2109558456 cites W1978890358 @default.
• W2109558456 cites W1983435458 @default.
• W2109558456 cites W1999144596 @default.
• W2109558456 cites W2045329873 @default.
• W2109558456 cites W2085522391 @default.
• W2109558456 cites W2125825441 @default.
• W2109558456 cites W2127004861 @default.
• W2109558456 cites W2146187080 @default.
• W2109558456 cites W2161182074 @default.
• W2109558456 cites W2314598837 @default.
• W2109558456 cites W4234046038 @default.
• W2109558456 doi "https://doi.org/10.1016/j.bmcl.2011.06.131" @default.
• W2109558456 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21807510" @default.
• W2109558456 hasPublicationYear "2011" @default.
• W2109558456 type Work @default.
• W2109558456 sameAs 2109558456 @default.
• W2109558456 citedByCount "22" @default.
• W2109558456 countsByYear W21095584562012 @default.
• W2109558456 countsByYear W21095584562013 @default.
• W2109558456 countsByYear W21095584562015 @default.
• W2109558456 countsByYear W21095584562017 @default.
• W2109558456 countsByYear W21095584562018 @default.
• W2109558456 countsByYear W21095584562019 @default.
• W2109558456 countsByYear W21095584562020 @default.
• W2109558456 countsByYear W21095584562021 @default.
• W2109558456 countsByYear W21095584562022 @default.
• W2109558456 countsByYear W21095584562023 @default.
• W2109558456 crossrefType "journal-article" @default.
• W2109558456 hasAuthorship W2109558456A5004159421 @default.
• W2109558456 hasAuthorship W2109558456A5005778914 @default.
• W2109558456 hasAuthorship W2109558456A5026635178 @default.
• W2109558456 hasAuthorship W2109558456A5048371616 @default.
• W2109558456 hasAuthorship W2109558456A5050360058 @default.
• W2109558456 hasAuthorship W2109558456A5058986690 @default.
• W2109558456 hasAuthorship W2109558456A5073598703 @default.
• W2109558456 hasAuthorship W2109558456A5085908396 @default.
• W2109558456 hasConcept C104629339 @default.
• W2109558456 hasConcept C114373084 @default.
• W2109558456 hasConcept C178790620 @default.
• W2109558456 hasConcept C181199279 @default.
• W2109558456 hasConcept C182996813 @default.
• W2109558456 hasConcept C184235292 @default.
• W2109558456 hasConcept C185592680 @default.
• W2109558456 hasConcept C192118531 @default.
• W2109558456 hasConcept C193042331 @default.
• W2109558456 hasConcept C202751555 @default.
• W2109558456 hasConcept C21951064 @default.
• W2109558456 hasConcept C2776568683 @default.
• W2109558456 hasConcept C2780263894 @default.
• W2109558456 hasConcept C2781076698 @default.
• W2109558456 hasConcept C39409265 @default.
• W2109558456 hasConcept C55493867 @default.
• W2109558456 hasConcept C71240020 @default.
• W2109558456 hasConcept C74187038 @default.
• W2109558456 hasConceptScore W2109558456C104629339 @default.
• W2109558456 hasConceptScore W2109558456C114373084 @default.
• W2109558456 hasConceptScore W2109558456C178790620 @default.
• W2109558456 hasConceptScore W2109558456C181199279 @default.
• W2109558456 hasConceptScore W2109558456C182996813 @default.
• W2109558456 hasConceptScore W2109558456C184235292 @default.
• W2109558456 hasConceptScore W2109558456C185592680 @default.
• W2109558456 hasConceptScore W2109558456C192118531 @default.
• W2109558456 hasConceptScore W2109558456C193042331 @default.
• W2109558456 hasConceptScore W2109558456C202751555 @default.
• W2109558456 hasConceptScore W2109558456C21951064 @default.
• W2109558456 hasConceptScore W2109558456C2776568683 @default.
• W2109558456 hasConceptScore W2109558456C2780263894 @default.
• W2109558456 hasConceptScore W2109558456C2781076698 @default.
• W2109558456 hasConceptScore W2109558456C39409265 @default.
• W2109558456 hasConceptScore W2109558456C55493867 @default.
• W2109558456 hasConceptScore W2109558456C71240020 @default.
• W2109558456 hasConceptScore W2109558456C74187038 @default.
• W2109558456 hasIssue "18" @default.
• W2109558456 hasLocation W21095584561 @default.
• W2109558456 hasLocation W21095584562 @default.
• W2109558456 hasOpenAccess W2109558456 @default.
• W2109558456 hasPrimaryLocation W21095584561 @default.
• W2109558456 hasRelatedWork W1982958012 @default.
• W2109558456 hasRelatedWork W1989257017 @default.
• W2109558456 hasRelatedWork W2037783340 @default.
• W2109558456 hasRelatedWork W2038474939 @default.

• next