Matches in SemOpenAlex for { <https://semopenalex.org/work/W2109562007> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2109562007 endingPage "1157" @default.
- W2109562007 startingPage "1149" @default.
- W2109562007 abstract "The aim of the present study was to demonstrate the application of an automated high-throughput (HT) dissolution method as a useful screening tool for characterization of controlled release pellets in the formulation development phase. Five controlled release pellet formulations with drug substances exhibiting high or low solubility were chosen to investigate the correlation of the automated HT dissolution method with the conventional dissolution testing. Overall, excellent correlations (R2 > 0.96) between the HT and the conventional dissolution method were obtained. In one case the initial unsatisfactory correlation (R2 = 0.84) and poor method agreement (SD = 12.5) was improved by optimizing the HT dissolution method with design of experiment approach. Here in comparison to initial experimental HT dissolution settings, increased amount of pellets (25% of the capsule filling mass), lower temperature (22 °C) and no shaking resulted in significantly better correlation (R2 = 0.97) and method agreement (SD = 5.3). These results show that such optimization is valuable for the development of HT dissolution methods. In conclusion, the high correlation of dissolution profiles obtained from the conventional and the automated HT dissolution method combined with low within-sample and measurement system variability, justifies the utilization of the automated HT dissolution method during development phase of controlled release pellets." @default.
- W2109562007 created "2016-06-24" @default.
- W2109562007 creator A5028469811 @default.
- W2109562007 creator A5036951144 @default.
- W2109562007 creator A5050022867 @default.
- W2109562007 creator A5079054087 @default.
- W2109562007 date "2015-12-17" @default.
- W2109562007 modified "2023-09-25" @default.
- W2109562007 title "High-throughput automated dissolution method applicable for a wide dose range of controlled release pellets" @default.
- W2109562007 cites W1498305210 @default.
- W2109562007 cites W1499768710 @default.
- W2109562007 cites W1964575627 @default.
- W2109562007 cites W1976221502 @default.
- W2109562007 cites W1982071369 @default.
- W2109562007 cites W1991847831 @default.
- W2109562007 cites W1992003475 @default.
- W2109562007 cites W1993254190 @default.
- W2109562007 cites W1993891338 @default.
- W2109562007 cites W2004682842 @default.
- W2109562007 cites W2009213615 @default.
- W2109562007 cites W2014307488 @default.
- W2109562007 cites W2039099865 @default.
- W2109562007 cites W2039721926 @default.
- W2109562007 cites W2043285199 @default.
- W2109562007 cites W2052323048 @default.
- W2109562007 cites W2060816850 @default.
- W2109562007 cites W2068771102 @default.
- W2109562007 cites W2079487493 @default.
- W2109562007 cites W2108130662 @default.
- W2109562007 cites W2124084576 @default.
- W2109562007 cites W2169443538 @default.
- W2109562007 cites W30775475 @default.
- W2109562007 cites W4249810852 @default.
- W2109562007 doi "https://doi.org/10.3109/03639045.2015.1117485" @default.
- W2109562007 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26552838" @default.
- W2109562007 hasPublicationYear "2015" @default.
- W2109562007 type Work @default.
- W2109562007 sameAs 2109562007 @default.
- W2109562007 citedByCount "4" @default.
- W2109562007 countsByYear W21095620072018 @default.
- W2109562007 countsByYear W21095620072021 @default.
- W2109562007 crossrefType "journal-article" @default.
- W2109562007 hasAuthorship W2109562007A5028469811 @default.
- W2109562007 hasAuthorship W2109562007A5036951144 @default.
- W2109562007 hasAuthorship W2109562007A5050022867 @default.
- W2109562007 hasAuthorship W2109562007A5079054087 @default.
- W2109562007 hasConcept C14029885 @default.
- W2109562007 hasConcept C147789679 @default.
- W2109562007 hasConcept C155574463 @default.
- W2109562007 hasConcept C159985019 @default.
- W2109562007 hasConcept C178790620 @default.
- W2109562007 hasConcept C17923525 @default.
- W2109562007 hasConcept C185592680 @default.
- W2109562007 hasConcept C192562407 @default.
- W2109562007 hasConcept C2780584874 @default.
- W2109562007 hasConcept C2781430271 @default.
- W2109562007 hasConcept C43617362 @default.
- W2109562007 hasConcept C77281830 @default.
- W2109562007 hasConcept C88380143 @default.
- W2109562007 hasConceptScore W2109562007C14029885 @default.
- W2109562007 hasConceptScore W2109562007C147789679 @default.
- W2109562007 hasConceptScore W2109562007C155574463 @default.
- W2109562007 hasConceptScore W2109562007C159985019 @default.
- W2109562007 hasConceptScore W2109562007C178790620 @default.
- W2109562007 hasConceptScore W2109562007C17923525 @default.
- W2109562007 hasConceptScore W2109562007C185592680 @default.
- W2109562007 hasConceptScore W2109562007C192562407 @default.
- W2109562007 hasConceptScore W2109562007C2780584874 @default.
- W2109562007 hasConceptScore W2109562007C2781430271 @default.
- W2109562007 hasConceptScore W2109562007C43617362 @default.
- W2109562007 hasConceptScore W2109562007C77281830 @default.
- W2109562007 hasConceptScore W2109562007C88380143 @default.
- W2109562007 hasIssue "7" @default.
- W2109562007 hasLocation W21095620071 @default.
- W2109562007 hasLocation W21095620072 @default.
- W2109562007 hasOpenAccess W2109562007 @default.
- W2109562007 hasPrimaryLocation W21095620071 @default.
- W2109562007 hasRelatedWork W1971335282 @default.
- W2109562007 hasRelatedWork W1986061657 @default.
- W2109562007 hasRelatedWork W2061376222 @default.
- W2109562007 hasRelatedWork W2065013224 @default.
- W2109562007 hasRelatedWork W2074060618 @default.
- W2109562007 hasRelatedWork W2109562007 @default.
- W2109562007 hasRelatedWork W2363871200 @default.
- W2109562007 hasRelatedWork W2379584319 @default.
- W2109562007 hasRelatedWork W3100975168 @default.
- W2109562007 hasRelatedWork W4297973806 @default.
- W2109562007 hasVolume "42" @default.
- W2109562007 isParatext "false" @default.
- W2109562007 isRetracted "false" @default.
- W2109562007 magId "2109562007" @default.
- W2109562007 workType "article" @default.