FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2109572007> ?p ?o ?g. }

• W2109572007 endingPage "292" @default.
• W2109572007 startingPage "266" @default.
• W2109572007 abstract "The tripartite-harmonized International Conference on Harmonization reproductive guideline (1993) recommends administration of test substances for 4 weeks to male rats before mating. However, scientific or experimental rationale for this recommendation is not firmly based, and the most appropriate parameters have not been established in experimental models. Therefore, a team consisting of 16 Japanese pharmaceutical companies and the National Institute of Health Sciences performed a collaborative study to determine the optimal period and parameters for detection of male fertility disorders in rats. Sixteen compounds, including four anticancer drugs, two psychotropic drugs, two nootropic drugs, two vitamins, two hormones, one antihypertensive agent, one diuretic drug, and two general chemicals were administered to male rats for 4 or 9 weeks before mating. Parameters used to examine effects on the male reproductive system were organ weights, sper-matogenic endpoints, mating behavior, cesarean section findings, and histopathology. From the results, treatment for 4 weeks before mating was concluded to be sufficient to detect adverse effects on male fertility, with the histopathology of the testis being the most sensitive index for the drugs used. Sperm parameters, especially number, and genital organ weight determination provided information confirming toxicity. Tests of reproductive activity were generally found to be insensitive, except where the drugs affected sperm maturation. Based on this study, it is concluded that a 4-week treatment period is appropriate for detection of drug effects on male fertility, and that histopath-ological examination of the testis is the most sensitive approach." @default.
• W2109572007 created "2016-06-24" @default.
• W2109572007 creator A5063218521 @default.
• W2109572007 creator A5063381098 @default.
• W2109572007 creator A5073117349 @default.
• W2109572007 creator A5075582606 @default.
• W2109572007 creator A5087560757 @default.
• W2109572007 date "1995-08-01" @default.
• W2109572007 modified "2023-09-25" @default.
• W2109572007 title "A Collaborative Study in Japan on Optimal Treatment Period and Parameters for Detection of Male Fertility Disorders Induced by Drugs in Rats" @default.
• W2109572007 cites W1544930851 @default.
• W2109572007 cites W1662034456 @default.
• W2109572007 cites W1966120283 @default.
• W2109572007 cites W1982043343 @default.
• W2109572007 cites W2011399384 @default.
• W2109572007 cites W2013471172 @default.
• W2109572007 cites W2014200429 @default.
• W2109572007 cites W2027463641 @default.
• W2109572007 cites W2045887466 @default.
• W2109572007 cites W2060636352 @default.
• W2109572007 cites W2077125174 @default.
• W2109572007 cites W2139629721 @default.
• W2109572007 cites W2329883125 @default.
• W2109572007 cites W2499364187 @default.
• W2109572007 cites W2897822445 @default.
• W2109572007 cites W3020872976 @default.
• W2109572007 cites W4244141322 @default.
• W2109572007 doi "https://doi.org/10.3109/10915819509008702" @default.
• W2109572007 hasPublicationYear "1995" @default.
• W2109572007 type Work @default.
• W2109572007 sameAs 2109572007 @default.
• W2109572007 citedByCount "73" @default.
• W2109572007 countsByYear W21095720072012 @default.
• W2109572007 countsByYear W21095720072013 @default.
• W2109572007 countsByYear W21095720072015 @default.
• W2109572007 countsByYear W21095720072016 @default.
• W2109572007 countsByYear W21095720072017 @default.
• W2109572007 countsByYear W21095720072018 @default.
• W2109572007 countsByYear W21095720072020 @default.
• W2109572007 crossrefType "journal-article" @default.
• W2109572007 hasAuthorship W2109572007A5063218521 @default.
• W2109572007 hasAuthorship W2109572007A5063381098 @default.
• W2109572007 hasAuthorship W2109572007A5073117349 @default.
• W2109572007 hasAuthorship W2109572007A5075582606 @default.
• W2109572007 hasAuthorship W2109572007A5087560757 @default.
• W2109572007 hasBestOaLocation W21095720071 @default.
• W2109572007 hasConcept C126322002 @default.
• W2109572007 hasConcept C142724271 @default.
• W2109572007 hasConcept C16685009 @default.
• W2109572007 hasConcept C183021626 @default.
• W2109572007 hasConcept C197934379 @default.
• W2109572007 hasConcept C2780035454 @default.
• W2109572007 hasConcept C2781087480 @default.
• W2109572007 hasConcept C2908647359 @default.
• W2109572007 hasConcept C33070731 @default.
• W2109572007 hasConcept C42407357 @default.
• W2109572007 hasConcept C514575182 @default.
• W2109572007 hasConcept C518429986 @default.
• W2109572007 hasConcept C54355233 @default.
• W2109572007 hasConcept C544855455 @default.
• W2109572007 hasConcept C71924100 @default.
• W2109572007 hasConcept C86803240 @default.
• W2109572007 hasConcept C90856448 @default.
• W2109572007 hasConcept C98274493 @default.
• W2109572007 hasConcept C99454951 @default.
• W2109572007 hasConceptScore W2109572007C126322002 @default.
• W2109572007 hasConceptScore W2109572007C142724271 @default.
• W2109572007 hasConceptScore W2109572007C16685009 @default.
• W2109572007 hasConceptScore W2109572007C183021626 @default.
• W2109572007 hasConceptScore W2109572007C197934379 @default.
• W2109572007 hasConceptScore W2109572007C2780035454 @default.
• W2109572007 hasConceptScore W2109572007C2781087480 @default.
• W2109572007 hasConceptScore W2109572007C2908647359 @default.
• W2109572007 hasConceptScore W2109572007C33070731 @default.
• W2109572007 hasConceptScore W2109572007C42407357 @default.
• W2109572007 hasConceptScore W2109572007C514575182 @default.
• W2109572007 hasConceptScore W2109572007C518429986 @default.
• W2109572007 hasConceptScore W2109572007C54355233 @default.
• W2109572007 hasConceptScore W2109572007C544855455 @default.
• W2109572007 hasConceptScore W2109572007C71924100 @default.
• W2109572007 hasConceptScore W2109572007C86803240 @default.
• W2109572007 hasConceptScore W2109572007C90856448 @default.
• W2109572007 hasConceptScore W2109572007C98274493 @default.
• W2109572007 hasConceptScore W2109572007C99454951 @default.
• W2109572007 hasIssue "4" @default.
• W2109572007 hasLocation W21095720071 @default.
• W2109572007 hasOpenAccess W2109572007 @default.
• W2109572007 hasPrimaryLocation W21095720071 @default.
• W2109572007 hasRelatedWork W105719178 @default.
• W2109572007 hasRelatedWork W2004074010 @default.
• W2109572007 hasRelatedWork W2008704455 @default.
• W2109572007 hasRelatedWork W2010698164 @default.
• W2109572007 hasRelatedWork W2089342187 @default.
• W2109572007 hasRelatedWork W2110061007 @default.
• W2109572007 hasRelatedWork W2176337987 @default.
• W2109572007 hasRelatedWork W2946989404 @default.
• W2109572007 hasRelatedWork W4212982335 @default.
• W2109572007 hasRelatedWork W4246356682 @default.

• next