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• W2109572722 abstract "Pulmonary alveolar proteinosis (PAP) is a rare disease characterized by the accumulation of surfactant-like lipoproteinaceous material in the distal air spaces and terminal bronchi, which may lead to impaired gas exchange. This accumulation of surfactant is due to decreased clearance by the alveolar macrophages. Its primary, most common form, is currently considered an autoimmune disease. Better knowledge of the causes of PAP have led to the emergence of alternatives to whole lung lavage, although this is still considered the treatment of choice. Most studies are case series, often with limited patient numbers, so the level of evidence is low. Since the severity of presentation and clinical course are variable, not all patients will require treatment. Due to the low level of evidence, some objective criteria based on expert opinion have been arbitrarily proposed in an attempt to define in which patients it is best to initiate treatment." @default.
• W2109572722 created "2016-06-24" @default.
• W2109572722 creator A5027989298 @default.
• W2109572722 date "2015-07-01" @default.
• W2109572722 modified "2023-10-03" @default.
• W2109572722 title "Tratamiento de la proteinosis alveolar primaria del adulto" @default.
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• W2109572722 doi "https://doi.org/10.1016/j.arbres.2015.02.003" @default.
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