Matches in SemOpenAlex for { <https://semopenalex.org/work/W2109573712> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2109573712 endingPage "334" @default.
- W2109573712 startingPage "329" @default.
- W2109573712 abstract "Oxygen promotes closure of the ductus arteriosus at birth. We have previously presented a scheme for oxygen action with a cytochrome P450 (CYP450) hemoprotein and endothelin-1 (ET-1) being, respectively, sensor and effector, and a hypothetical monooxygenase product serving as a coupling link. We have also found in the vessel arachidonic acid (AA) 12(S)-lipoxygenase (12-lipoxygenase) undergoing upregulation at birth. Here, we examined the feasibility of a sensor-to-effector messenger originating from AA monooxygenase and 12-lipoxygenase pathways. The epoxygenase inhibitor, N-methylsulfonyl-6-(2-)hexanamide, suppressed the tonic contraction of ductus to oxygen. A similar effect was obtained with 12-lipoxygenase inhibitors baicalein and PD 146176. By contrast, none of the inhibitors modified the endothelin-1 contraction. Furthermore, an AA ω-hydroxylation product, 20-hydroxyeicosatetraenoic acid (20-HETE), reportedly responsible for oxygen contraction in the systemic microvasculature, had no such effect on the ductus. We conclude that AA epoxygenase and 12-lipoxygenase jointly produce a hitherto uncharacterized compound acting as oxygen messenger in the ductus." @default.
- W2109573712 created "2016-06-24" @default.
- W2109573712 creator A5012624770 @default.
- W2109573712 creator A5085782800 @default.
- W2109573712 date "2011-05-01" @default.
- W2109573712 modified "2023-09-25" @default.
- W2109573712 title "Arachidonic acid epoxygenase and 12(<i>S</i>)-lipoxygenase: evidence of their concerted involvement in ductus arteriosus constriction to oxygen" @default.
- W2109573712 cites W1991345681 @default.
- W2109573712 cites W2018341078 @default.
- W2109573712 cites W2021241846 @default.
- W2109573712 cites W2043036244 @default.
- W2109573712 cites W2056852438 @default.
- W2109573712 cites W2057755427 @default.
- W2109573712 cites W2062217286 @default.
- W2109573712 cites W2074882875 @default.
- W2109573712 cites W2087316972 @default.
- W2109573712 cites W2107543261 @default.
- W2109573712 cites W2118672096 @default.
- W2109573712 cites W2147832561 @default.
- W2109573712 cites W2148894239 @default.
- W2109573712 cites W2150549589 @default.
- W2109573712 cites W2155115159 @default.
- W2109573712 cites W2184075644 @default.
- W2109573712 cites W2187351197 @default.
- W2109573712 cites W4250797512 @default.
- W2109573712 doi "https://doi.org/10.1139/y11-025" @default.
- W2109573712 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21619415" @default.
- W2109573712 hasPublicationYear "2011" @default.
- W2109573712 type Work @default.
- W2109573712 sameAs 2109573712 @default.
- W2109573712 citedByCount "9" @default.
- W2109573712 countsByYear W21095737122012 @default.
- W2109573712 countsByYear W21095737122013 @default.
- W2109573712 countsByYear W21095737122014 @default.
- W2109573712 countsByYear W21095737122017 @default.
- W2109573712 countsByYear W21095737122020 @default.
- W2109573712 crossrefType "journal-article" @default.
- W2109573712 hasAuthorship W2109573712A5012624770 @default.
- W2109573712 hasAuthorship W2109573712A5085782800 @default.
- W2109573712 hasBestOaLocation W21095737122 @default.
- W2109573712 hasConcept C126322002 @default.
- W2109573712 hasConcept C13002179 @default.
- W2109573712 hasConcept C134018914 @default.
- W2109573712 hasConcept C181199279 @default.
- W2109573712 hasConcept C185592680 @default.
- W2109573712 hasConcept C2776042228 @default.
- W2109573712 hasConcept C2776452501 @default.
- W2109573712 hasConcept C2778078955 @default.
- W2109573712 hasConcept C2779396086 @default.
- W2109573712 hasConcept C2780857362 @default.
- W2109573712 hasConcept C2781236024 @default.
- W2109573712 hasConcept C519581460 @default.
- W2109573712 hasConcept C526171541 @default.
- W2109573712 hasConcept C55493867 @default.
- W2109573712 hasConcept C71924100 @default.
- W2109573712 hasConcept C86803240 @default.
- W2109573712 hasConceptScore W2109573712C126322002 @default.
- W2109573712 hasConceptScore W2109573712C13002179 @default.
- W2109573712 hasConceptScore W2109573712C134018914 @default.
- W2109573712 hasConceptScore W2109573712C181199279 @default.
- W2109573712 hasConceptScore W2109573712C185592680 @default.
- W2109573712 hasConceptScore W2109573712C2776042228 @default.
- W2109573712 hasConceptScore W2109573712C2776452501 @default.
- W2109573712 hasConceptScore W2109573712C2778078955 @default.
- W2109573712 hasConceptScore W2109573712C2779396086 @default.
- W2109573712 hasConceptScore W2109573712C2780857362 @default.
- W2109573712 hasConceptScore W2109573712C2781236024 @default.
- W2109573712 hasConceptScore W2109573712C519581460 @default.
- W2109573712 hasConceptScore W2109573712C526171541 @default.
- W2109573712 hasConceptScore W2109573712C55493867 @default.
- W2109573712 hasConceptScore W2109573712C71924100 @default.
- W2109573712 hasConceptScore W2109573712C86803240 @default.
- W2109573712 hasIssue "5" @default.
- W2109573712 hasLocation W21095737121 @default.
- W2109573712 hasLocation W21095737122 @default.
- W2109573712 hasLocation W21095737123 @default.
- W2109573712 hasOpenAccess W2109573712 @default.
- W2109573712 hasPrimaryLocation W21095737121 @default.
- W2109573712 hasRelatedWork W1580847222 @default.
- W2109573712 hasRelatedWork W1993404169 @default.
- W2109573712 hasRelatedWork W2009454127 @default.
- W2109573712 hasRelatedWork W2042089290 @default.
- W2109573712 hasRelatedWork W2045822258 @default.
- W2109573712 hasRelatedWork W2109573712 @default.
- W2109573712 hasRelatedWork W2139086060 @default.
- W2109573712 hasRelatedWork W2182635476 @default.
- W2109573712 hasRelatedWork W2965888264 @default.
- W2109573712 hasRelatedWork W49849679 @default.
- W2109573712 hasVolume "89" @default.
- W2109573712 isParatext "false" @default.
- W2109573712 isRetracted "false" @default.
- W2109573712 magId "2109573712" @default.
- W2109573712 workType "article" @default.