Matches in SemOpenAlex for { <https://semopenalex.org/work/W2109582180> ?p ?o ?g. }
Showing items 1 to 61 of
61
with 100 items per page.
- W2109582180 endingPage "79" @default.
- W2109582180 startingPage "76" @default.
- W2109582180 abstract "In rheumatoid arthritis (RA) chronic inflammation results in pain, swelling and ultimately destruction of joints. This inflammation is also related to systemic bone loss and an increased fracture risk. Glucocorticoids (GC) are widely used to suppress the symptoms of inflammation in RA. There is increasing evidence from clinical studies that GC are disease modifying, in early disease and in combination with slow acting anti-rheumatic drugs. The effects of GC on joint destruction remain a matter of debate. However, some safety issues remain to be considered for long-term treatment, related to high cumulative doses such as the dose-related risk for glucocorticoid induced osteoporosis (GIOP). Moreover, data from in vitro studies on chondrocyte cultures question the cartilage-preserving function that has been attributed to GC. Combination with bisphosphonates can be advocated as these compounds protect against GIOP and chondrocyte apoptosis. In conclusion, GC may have a disease modifying role in RA, but they have to be used in combination with other disease modifying anti-rheumatic drugs and a bisphosphonate. Keywords: Rheumatoid arthritis, glucocorticosteroids, osteoporosis, joint destruction" @default.
- W2109582180 created "2016-06-24" @default.
- W2109582180 creator A5005164429 @default.
- W2109582180 creator A5015844269 @default.
- W2109582180 creator A5037598384 @default.
- W2109582180 creator A5041256007 @default.
- W2109582180 creator A5086978817 @default.
- W2109582180 date "2008-02-01" @default.
- W2109582180 modified "2023-10-18" @default.
- W2109582180 title "Glucocorticoids and their Effects on Bone and Joints in Rheumatoid Arthritis" @default.
- W2109582180 doi "https://doi.org/10.2174/157339708783497946" @default.
- W2109582180 hasPublicationYear "2008" @default.
- W2109582180 type Work @default.
- W2109582180 sameAs 2109582180 @default.
- W2109582180 citedByCount "1" @default.
- W2109582180 countsByYear W21095821802012 @default.
- W2109582180 crossrefType "journal-article" @default.
- W2109582180 hasAuthorship W2109582180A5005164429 @default.
- W2109582180 hasAuthorship W2109582180A5015844269 @default.
- W2109582180 hasAuthorship W2109582180A5037598384 @default.
- W2109582180 hasAuthorship W2109582180A5041256007 @default.
- W2109582180 hasAuthorship W2109582180A5086978817 @default.
- W2109582180 hasConcept C126322002 @default.
- W2109582180 hasConcept C2776541429 @default.
- W2109582180 hasConcept C2776914184 @default.
- W2109582180 hasConcept C2777077863 @default.
- W2109582180 hasConcept C2777251235 @default.
- W2109582180 hasConcept C2777575956 @default.
- W2109582180 hasConcept C2779134260 @default.
- W2109582180 hasConcept C2780841215 @default.
- W2109582180 hasConcept C71924100 @default.
- W2109582180 hasConceptScore W2109582180C126322002 @default.
- W2109582180 hasConceptScore W2109582180C2776541429 @default.
- W2109582180 hasConceptScore W2109582180C2776914184 @default.
- W2109582180 hasConceptScore W2109582180C2777077863 @default.
- W2109582180 hasConceptScore W2109582180C2777251235 @default.
- W2109582180 hasConceptScore W2109582180C2777575956 @default.
- W2109582180 hasConceptScore W2109582180C2779134260 @default.
- W2109582180 hasConceptScore W2109582180C2780841215 @default.
- W2109582180 hasConceptScore W2109582180C71924100 @default.
- W2109582180 hasIssue "1" @default.
- W2109582180 hasLocation W21095821801 @default.
- W2109582180 hasOpenAccess W2109582180 @default.
- W2109582180 hasPrimaryLocation W21095821801 @default.
- W2109582180 hasRelatedWork W1983172052 @default.
- W2109582180 hasRelatedWork W1999314656 @default.
- W2109582180 hasRelatedWork W2005517874 @default.
- W2109582180 hasRelatedWork W2013438175 @default.
- W2109582180 hasRelatedWork W2084740751 @default.
- W2109582180 hasRelatedWork W2134592607 @default.
- W2109582180 hasRelatedWork W2338134927 @default.
- W2109582180 hasRelatedWork W2395484132 @default.
- W2109582180 hasRelatedWork W2417015447 @default.
- W2109582180 hasRelatedWork W2580494381 @default.
- W2109582180 hasVolume "4" @default.
- W2109582180 isParatext "false" @default.
- W2109582180 isRetracted "false" @default.
- W2109582180 magId "2109582180" @default.
- W2109582180 workType "article" @default.