FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2109585910> ?p ?o ?g. }

• W2109585910 endingPage "34" @default.
• W2109585910 startingPage "29" @default.
• W2109585910 abstract "The advent of radioimmunoassay for the major metabolite of prostaglandin F2α (PGF2α), 15-keto-13, 14-dihydro-PGF2α (15-ketodihydro-PGF2α), has allowed the dynamics of PGF2α, secretion to be studied in a variety of physiological and pathological situations in domestic animals, including the mare. In the non-pregnant cyclic mare, PGF2α is responsible for the regression of the corpus luteum. In the pregnant mare, pulsatile secretion of PGF2α is blocked by the presence of the conceptus and the corpus luteum continues to secrete progesterone, essential to the support of pregnancy. At term, the massive increase in PGF2α synthesis is the major stimulus for uterine contractions during delivery. The endometrium of the non-pregnant mare secretes PGF2α in response to inflammatory changes caused by bacterial infection, intra-uterine infusion of saline (low pH) or other irritants; the amount of PGF2α released is often sufficient to initiate luteolysis. In the pregnant mare, stimuli that can initiate PGF2α secretion by the endometrium include uterine and cervical manipulation, chronic uterine inflammation, surgical manipulation of the uterus in conjunction with removal of one of twin conceptuses and manual rupture of one embryonic vesicle per rectum in mares carrying twins. Prostaglandin F2α can be released by tissues other than the uterus. Systemic administration of endotoxin will induce the synthesis and release of PGF2α. The secretion of PGF2α in this situation can result in a decrease of luteal function or complete luteolysis in both the non-pregnant and pregnant mare. In mares less than 55 days pregnant, compromised luteal activity following the administration of endotoxin results in death of the conceptus. Ongoing studies indicate that flunixin meglumine, a non-steroidal anti-inflammatory drug, effectively blocks PGF2α secretion and can be used to prevent embryonic death in the event of endotoxaemia. Altrenogest can be used as an alternative treatment for the prevention of embryonic death. To be effective, flunixin meglumine must be administered soon after the onset of endotoxaemia whereas altrenogest treatment can be initiated up to 12 h later and still prevent pregnancy loss." @default.
• W2109585910 created "2016-06-24" @default.
• W2109585910 creator A5031295920 @default.
• W2109585910 creator A5036471163 @default.
• W2109585910 creator A5056466227 @default.
• W2109585910 creator A5068767307 @default.
• W2109585910 date "2010-06-10" @default.
• W2109585910 modified "2023-10-16" @default.
• W2109585910 title "Prostaglandin release and luteolysis associated with physiological and pathological conditions of the reproductive cycle of the mare: a review" @default.
• W2109585910 cites W1529605837 @default.
• W2109585910 cites W1965183724 @default.
• W2109585910 cites W1967506360 @default.
• W2109585910 cites W1981580393 @default.
• W2109585910 cites W1993927658 @default.
• W2109585910 cites W1995626394 @default.
• W2109585910 cites W2001464522 @default.
• W2109585910 cites W2002497773 @default.
• W2109585910 cites W2003543263 @default.
• W2109585910 cites W2006661974 @default.
• W2109585910 cites W2007260155 @default.
• W2109585910 cites W2008814243 @default.
• W2109585910 cites W2022151335 @default.
• W2109585910 cites W2032099499 @default.
• W2109585910 cites W2033915081 @default.
• W2109585910 cites W2037948388 @default.
• W2109585910 cites W2039228913 @default.
• W2109585910 cites W2039697342 @default.
• W2109585910 cites W2050662843 @default.
• W2109585910 cites W2053899595 @default.
• W2109585910 cites W2054656162 @default.
• W2109585910 cites W2055927300 @default.
• W2109585910 cites W2057234936 @default.
• W2109585910 cites W2060815376 @default.
• W2109585910 cites W2068697642 @default.
• W2109585910 cites W2075572856 @default.
• W2109585910 cites W2078016664 @default.
• W2109585910 cites W2079757060 @default.
• W2109585910 cites W2080859439 @default.
• W2109585910 cites W2084154735 @default.
• W2109585910 cites W2087854447 @default.
• W2109585910 cites W2088103319 @default.
• W2109585910 cites W2090235210 @default.
• W2109585910 cites W2090621368 @default.
• W2109585910 cites W2092739483 @default.
• W2109585910 cites W2102049214 @default.
• W2109585910 cites W2103326426 @default.
• W2109585910 cites W2107670058 @default.
• W2109585910 cites W2131102065 @default.
• W2109585910 cites W2326577179 @default.
• W2109585910 cites W2333342647 @default.
• W2109585910 cites W2401672077 @default.
• W2109585910 cites W2418937632 @default.
• W2109585910 cites W2897508624 @default.
• W2109585910 cites W29245845 @default.
• W2109585910 cites W2019211047 @default.
• W2109585910 doi "https://doi.org/10.1111/j.2042-3306.1989.tb04669.x" @default.
• W2109585910 hasPublicationYear "2010" @default.
• W2109585910 type Work @default.
• W2109585910 sameAs 2109585910 @default.
• W2109585910 citedByCount "6" @default.
• W2109585910 countsByYear W21095859102013 @default.
• W2109585910 countsByYear W21095859102014 @default.
• W2109585910 countsByYear W21095859102015 @default.
• W2109585910 crossrefType "journal-article" @default.
• W2109585910 hasAuthorship W2109585910A5031295920 @default.
• W2109585910 hasAuthorship W2109585910A5036471163 @default.
• W2109585910 hasAuthorship W2109585910A5056466227 @default.
• W2109585910 hasAuthorship W2109585910A5068767307 @default.
• W2109585910 hasConcept C126322002 @default.
• W2109585910 hasConcept C134018914 @default.
• W2109585910 hasConcept C143228043 @default.
• W2109585910 hasConcept C187785154 @default.
• W2109585910 hasConcept C1998276 @default.
• W2109585910 hasConcept C2775846227 @default.
• W2109585910 hasConcept C2776608385 @default.
• W2109585910 hasConcept C2777330693 @default.
• W2109585910 hasConcept C2778324911 @default.
• W2109585910 hasConcept C2779066055 @default.
• W2109585910 hasConcept C2779234561 @default.
• W2109585910 hasConcept C2779742232 @default.
• W2109585910 hasConcept C2780664492 @default.
• W2109585910 hasConcept C2909370928 @default.
• W2109585910 hasConcept C32253518 @default.
• W2109585910 hasConcept C46973012 @default.
• W2109585910 hasConcept C54355233 @default.
• W2109585910 hasConcept C71924100 @default.
• W2109585910 hasConcept C86803240 @default.
• W2109585910 hasConceptScore W2109585910C126322002 @default.
• W2109585910 hasConceptScore W2109585910C134018914 @default.
• W2109585910 hasConceptScore W2109585910C143228043 @default.
• W2109585910 hasConceptScore W2109585910C187785154 @default.
• W2109585910 hasConceptScore W2109585910C1998276 @default.
• W2109585910 hasConceptScore W2109585910C2775846227 @default.
• W2109585910 hasConceptScore W2109585910C2776608385 @default.
• W2109585910 hasConceptScore W2109585910C2777330693 @default.
• W2109585910 hasConceptScore W2109585910C2778324911 @default.
• W2109585910 hasConceptScore W2109585910C2779066055 @default.
• W2109585910 hasConceptScore W2109585910C2779234561 @default.

• next