FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2109592439> ?p ?o ?g. }

• W2109592439 endingPage "139" @default.
• W2109592439 startingPage "133" @default.
• W2109592439 abstract "Pruritus is a common, distressing and difficult to manage complication of many autoimmune diseases. A suitable animal model of autoimmune disease associated pruritus would contribute to a better understanding of the pathophysiology of this symptom and lead to the development of safe and effective antipruritic agents. We noticed spontaneous scratching behavior in aged MRL/lpr mice, a model of autoimmune disease. This scratching behavior was observed in a specific pathogen-free environment and was more frequent in female mice. In contrast to animal models of dermatitis; NC/Nga mice, the serum IgE and IgG1 levels in MRL/lpr mice were not elevated. These features indicate that this scratching behavior is similar to human autoimmune disease associated pruritus. The antipruritic effects of an antihistamine (chlorpheniramine), an opioid receptor antagonist (naltrexone), and a novel κ-opioid receptor agonist (nalfurafine hydrochloride [TRK-820]) were evaluated. The frequency of scratching was not reduced by oral administration of chlorpheniramine, suggesting that the behavior is antihistamine-resistant. The oral administration of nalfurafine and subcutaneously administered naltrexone inhibited the scratching behavior without causing gross behavioral changes. In conclusion, MRL/lpr mice scratching behavior is a suitable model of pruritus that occurs in autoimmune diseases, and nalfurafine was shown to be efficacious against this behavior suggesting that it may be beneficial in patients with autoimmune disease associated pruritus." @default.
• W2109592439 created "2016-06-24" @default.
• W2109592439 creator A5004138014 @default.
• W2109592439 creator A5007483753 @default.
• W2109592439 creator A5012607063 @default.
• W2109592439 creator A5022118963 @default.
• W2109592439 creator A5029678899 @default.
• W2109592439 creator A5042356652 @default.
• W2109592439 creator A5053163572 @default.
• W2109592439 creator A5059764811 @default.
• W2109592439 creator A5063089880 @default.
• W2109592439 creator A5063536929 @default.
• W2109592439 creator A5084065201 @default.
• W2109592439 date "2005-08-01" @default.
• W2109592439 modified "2023-10-17" @default.
• W2109592439 title "Spontaneous scratching behavior in MRL/lpr mice, a possible model for pruritus in autoimmune diseases, and antipruritic activity of a novel κ-opioid receptor agonist nalfurafine hydrochloride" @default.
• W2109592439 cites W1219313770 @default.
• W2109592439 cites W1495781935 @default.
• W2109592439 cites W1975305530 @default.
• W2109592439 cites W1983148582 @default.
• W2109592439 cites W1983871703 @default.
• W2109592439 cites W1987917226 @default.
• W2109592439 cites W1991166786 @default.
• W2109592439 cites W1993876930 @default.
• W2109592439 cites W2005621871 @default.
• W2109592439 cites W2008756039 @default.
• W2109592439 cites W2013569586 @default.
• W2109592439 cites W2014660507 @default.
• W2109592439 cites W2017176686 @default.
• W2109592439 cites W2019390260 @default.
• W2109592439 cites W2020850711 @default.
• W2109592439 cites W2031056551 @default.
• W2109592439 cites W2035183016 @default.
• W2109592439 cites W2039172739 @default.
• W2109592439 cites W2043872663 @default.
• W2109592439 cites W2046001091 @default.
• W2109592439 cites W2050861771 @default.
• W2109592439 cites W2056483924 @default.
• W2109592439 cites W2062077958 @default.
• W2109592439 cites W2062646060 @default.
• W2109592439 cites W2068463716 @default.
• W2109592439 cites W2075314339 @default.
• W2109592439 cites W2093395667 @default.
• W2109592439 cites W2094285893 @default.
• W2109592439 cites W2101799958 @default.
• W2109592439 cites W2108399692 @default.
• W2109592439 cites W2115079622 @default.
• W2109592439 cites W2122516449 @default.
• W2109592439 cites W2137722996 @default.
• W2109592439 cites W2149834061 @default.
• W2109592439 cites W2150842124 @default.
• W2109592439 cites W342849785 @default.
• W2109592439 doi "https://doi.org/10.1016/j.ejphar.2005.06.019" @default.
• W2109592439 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16055114" @default.
• W2109592439 hasPublicationYear "2005" @default.
• W2109592439 type Work @default.
• W2109592439 sameAs 2109592439 @default.
• W2109592439 citedByCount "32" @default.
• W2109592439 countsByYear W21095924392012 @default.
• W2109592439 countsByYear W21095924392013 @default.
• W2109592439 countsByYear W21095924392014 @default.
• W2109592439 countsByYear W21095924392015 @default.
• W2109592439 countsByYear W21095924392016 @default.
• W2109592439 countsByYear W21095924392019 @default.
• W2109592439 countsByYear W21095924392020 @default.
• W2109592439 countsByYear W21095924392021 @default.
• W2109592439 countsByYear W21095924392023 @default.
• W2109592439 crossrefType "journal-article" @default.
• W2109592439 hasAuthorship W2109592439A5004138014 @default.
• W2109592439 hasAuthorship W2109592439A5007483753 @default.
• W2109592439 hasAuthorship W2109592439A5012607063 @default.
• W2109592439 hasAuthorship W2109592439A5022118963 @default.
• W2109592439 hasAuthorship W2109592439A5029678899 @default.
• W2109592439 hasAuthorship W2109592439A5042356652 @default.
• W2109592439 hasAuthorship W2109592439A5053163572 @default.
• W2109592439 hasAuthorship W2109592439A5059764811 @default.
• W2109592439 hasAuthorship W2109592439A5063089880 @default.
• W2109592439 hasAuthorship W2109592439A5063536929 @default.
• W2109592439 hasAuthorship W2109592439A5084065201 @default.
• W2109592439 hasConcept C121332964 @default.
• W2109592439 hasConcept C126322002 @default.
• W2109592439 hasConcept C159654299 @default.
• W2109592439 hasConcept C170493617 @default.
• W2109592439 hasConcept C203014093 @default.
• W2109592439 hasConcept C24890656 @default.
• W2109592439 hasConcept C2776880894 @default.
• W2109592439 hasConcept C2776885963 @default.
• W2109592439 hasConcept C2777972943 @default.
• W2109592439 hasConcept C2778122271 @default.
• W2109592439 hasConcept C2778938600 @default.
• W2109592439 hasConcept C2779252107 @default.
• W2109592439 hasConcept C2780196728 @default.
• W2109592439 hasConcept C2780938799 @default.
• W2109592439 hasConcept C2781063702 @default.
• W2109592439 hasConcept C71924100 @default.
• W2109592439 hasConcept C98274493 @default.
• W2109592439 hasConceptScore W2109592439C121332964 @default.
• W2109592439 hasConceptScore W2109592439C126322002 @default.

• next