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• W2109592802 abstract "Background. We have demonstrated that donor cell chimerism is associated with a lower incidence of obliterative bronchiolitis (OB) in lung recipients, and that donor chimerism is augmented by the infusion of donor bone marrow (BM). We herein report the intermediate results of a trial combining the infusion of donor BM and lung transplantation.Methods. Clinical and in vitro data of 26 lung recipients receiving concurrent infusion of donor bone marrow (3.0 to 6.0 × 108 cells/kg) were compared with those of 13 patients receiving lung transplant alone.Results. Patient survival and freedom from acute rejection were similar between groups. Of the patients whose graft survived greater than 4 months, 5% (1 of 22) of BM and 33% (4 of 12) of control patients, developed histologic evidence of OB (p = 0.04). A higher proportion (but not statistically significant) of BM recipients (7 of 10, 70%) exhibited donor-specific hyporeactivity by mixed lymphocyte reaction assays as compared with the controls (2 of 7, 28%).Conclusions. Infusion of donor BM at the time of lung transplantation is safe, and is associated with recipients’ immune modulation and a lower rate of obliterative bronchiolitis." @default.
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• W2109592802 date "2000-02-01" @default.
• W2109592802 modified "2023-10-12" @default.
• W2109592802 title "Effects of donor bone marrow infusion in clinical lung transplantation" @default.
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• W2109592802 doi "https://doi.org/10.1016/s0003-4975(99)01471-x" @default.
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