FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2109593516> ?p ?o ?g. }

• W2109593516 endingPage "2226" @default.
• W2109593516 startingPage "2220" @default.
• W2109593516 abstract "Abstract CD4+ T cell differentiation and function are critically dependent on the type of APC and the microenvironment in which Ag presentation occurs. Most studies have documented the effect of dendritic cells on effector and regulatory T cell differentiation; however, macrophages are the most abundant APCs in the periphery and can be found in virtually all organs and tissues. The effect of macrophages, and in particular their subsets, on T cell function has received little attention. Previously, we described distinct subsets of human macrophages (pro- and anti-inflammatory, mφ1 and mφ2, respectively) with highly divergent cell surface Ag expression and cytokine/chemokine production. We reported that human mφ1 promote, whereas mφ2 decrease, Th1 activation. Here, we demonstrate that mφ2, but not mφ1, induce regulatory T cells with a strong suppressive phenotype (Tmφ2). Their mechanism of suppression is cell-cell contact dependent, mediated by membrane-bound TGFβ-1 expressed on the regulatory T cell (Treg) population since inhibition of TGFβ-1 signaling in target cells blocks the regulatory phenotype. Tmφ2, in addition to mediating cell-cell contact-dependent suppression, express typical Treg markers such as CD25, glucocorticoid-induced TNF receptor (GITR), and Foxp3 and are actively induced by mφ2 from CD25-depleted cells. These data identify mφ2 cells as a novel APC subset capable of inducing Tregs. The ability of anti-inflammatory macrophages to induce Tregs in the periphery has important implications for understanding Treg dynamics in pathological conditions where macrophages play a key role in inflammatory disease control and exacerbation." @default.
• W2109593516 created "2016-06-24" @default.
• W2109593516 creator A5004201118 @default.
• W2109593516 creator A5016521148 @default.
• W2109593516 creator A5027503902 @default.
• W2109593516 creator A5029055010 @default.
• W2109593516 creator A5042993542 @default.
• W2109593516 creator A5074035245 @default.
• W2109593516 creator A5087724247 @default.
• W2109593516 date "2008-08-01" @default.
• W2109593516 modified "2023-09-24" @default.
• W2109593516 title "Human Anti-Inflammatory Macrophages Induce Foxp3+GITR+CD25+ Regulatory T Cells, Which Suppress via Membrane-Bound TGFβ-1" @default.
• W2109593516 cites W1745273943 @default.
• W2109593516 cites W1898102248 @default.
• W2109593516 cites W1942388905 @default.
• W2109593516 cites W1967577988 @default.
• W2109593516 cites W1967603837 @default.
• W2109593516 cites W1984451487 @default.
• W2109593516 cites W1988474688 @default.
• W2109593516 cites W1990899950 @default.
• W2109593516 cites W1997398245 @default.
• W2109593516 cites W2002726823 @default.
• W2109593516 cites W2024483802 @default.
• W2109593516 cites W2026426963 @default.
• W2109593516 cites W2026836824 @default.
• W2109593516 cites W2070443202 @default.
• W2109593516 cites W2071734372 @default.
• W2109593516 cites W2081771448 @default.
• W2109593516 cites W2094663408 @default.
• W2109593516 cites W2095764253 @default.
• W2109593516 cites W2097811455 @default.
• W2109593516 cites W2117493229 @default.
• W2109593516 cites W2119194984 @default.
• W2109593516 cites W2122738080 @default.
• W2109593516 cites W2123518168 @default.
• W2109593516 cites W2136245823 @default.
• W2109593516 cites W2141324432 @default.
• W2109593516 cites W2151948277 @default.
• W2109593516 cites W2156626338 @default.
• W2109593516 cites W2158092720 @default.
• W2109593516 cites W2161545566 @default.
• W2109593516 cites W2164872587 @default.
• W2109593516 cites W2172116560 @default.
• W2109593516 cites W4234615218 @default.
• W2109593516 doi "https://doi.org/10.4049/jimmunol.181.3.2220" @default.
• W2109593516 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18641362" @default.
• W2109593516 hasPublicationYear "2008" @default.
• W2109593516 type Work @default.
• W2109593516 sameAs 2109593516 @default.
• W2109593516 citedByCount "222" @default.
• W2109593516 countsByYear W21095935162012 @default.
• W2109593516 countsByYear W21095935162013 @default.
• W2109593516 countsByYear W21095935162014 @default.
• W2109593516 countsByYear W21095935162015 @default.
• W2109593516 countsByYear W21095935162016 @default.
• W2109593516 countsByYear W21095935162017 @default.
• W2109593516 countsByYear W21095935162018 @default.
• W2109593516 countsByYear W21095935162019 @default.
• W2109593516 countsByYear W21095935162020 @default.
• W2109593516 countsByYear W21095935162021 @default.
• W2109593516 countsByYear W21095935162022 @default.
• W2109593516 countsByYear W21095935162023 @default.
• W2109593516 crossrefType "journal-article" @default.
• W2109593516 hasAuthorship W2109593516A5004201118 @default.
• W2109593516 hasAuthorship W2109593516A5016521148 @default.
• W2109593516 hasAuthorship W2109593516A5027503902 @default.
• W2109593516 hasAuthorship W2109593516A5029055010 @default.
• W2109593516 hasAuthorship W2109593516A5042993542 @default.
• W2109593516 hasAuthorship W2109593516A5074035245 @default.
• W2109593516 hasAuthorship W2109593516A5087724247 @default.
• W2109593516 hasBestOaLocation W21095935161 @default.
• W2109593516 hasConcept C13373296 @default.
• W2109593516 hasConcept C185592680 @default.
• W2109593516 hasConcept C203014093 @default.
• W2109593516 hasConcept C2776090121 @default.
• W2109593516 hasConcept C2776914184 @default.
• W2109593516 hasConcept C2778296632 @default.
• W2109593516 hasConcept C2778690821 @default.
• W2109593516 hasConcept C2779727006 @default.
• W2109593516 hasConcept C2908647359 @default.
• W2109593516 hasConcept C51785407 @default.
• W2109593516 hasConcept C67662055 @default.
• W2109593516 hasConcept C71924100 @default.
• W2109593516 hasConcept C79484868 @default.
• W2109593516 hasConcept C86803240 @default.
• W2109593516 hasConcept C8891405 @default.
• W2109593516 hasConcept C95444343 @default.
• W2109593516 hasConcept C99454951 @default.
• W2109593516 hasConceptScore W2109593516C13373296 @default.
• W2109593516 hasConceptScore W2109593516C185592680 @default.
• W2109593516 hasConceptScore W2109593516C203014093 @default.
• W2109593516 hasConceptScore W2109593516C2776090121 @default.
• W2109593516 hasConceptScore W2109593516C2776914184 @default.
• W2109593516 hasConceptScore W2109593516C2778296632 @default.
• W2109593516 hasConceptScore W2109593516C2778690821 @default.
• W2109593516 hasConceptScore W2109593516C2779727006 @default.
• W2109593516 hasConceptScore W2109593516C2908647359 @default.
• W2109593516 hasConceptScore W2109593516C51785407 @default.

• next