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- W2109597614 abstract "Simian immunodeficiency virus of chimpanzees (SIVcpz) is the immediate precursor to human immunodeficiency virus type 1 (HIV-1), yet remarkably, the distribution and prevalence of SIVcpz in wild ape populations are unknown. Studies of SIVcpz infection rates in wild chimpanzees are complicated by the species' endangered status and by its geographic location in remote areas of sub-Saharan Africa. We have developed sensitive and specific urine and fecal tests for SIVcpz antibody and virion RNA (vRNA) detection and describe herein the first comprehensive prevalence study of SIVcpz infection in five wild Pan troglodytes schweinfurthii communities in east Africa. In Kibale National Park in Uganda, 31 (of 52) members of the Kanyawara community and 39 (of approximately 145) members of the Ngogo community were studied; none were found to be positive for SIVcpz infection. In Gombe National Park in Tanzania, 15 (of 20) members of the Mitumba community, 51 (of 55) members of the Kasekela community, and at least 10 (of approximately 20) members of the Kalande community were studied. Seven individuals were SIVcpz antibody and/or vRNA positive, and two others had indeterminate antibody results. Based on assay sensitivities and the numbers and types of specimens analyzed, we estimated the prevalence of SIVcpz infection to be 17% in Mitumba (95% confidence interval, 10 to 40%), 5% in Kasekela (95% confidence interval, 4 to 7%), and 30% in Kalande (95% confidence interval, 15 to 60%). For Gombe as a whole, the SIVcpz prevalence was estimated to be 13% (95% confidence interval, 7 to 25%). SIVcpz infection was confirmed in five chimpanzees by PCR amplification of partial pol and gp41/nef sequences which revealed a diverse group of viruses that formed a monophyletic lineage within the SIVcpzPts radiation. Although none of the 70 Kibale chimpanzees tested SIVcpz positive, we estimated the likelihood that a 10% or higher prevalence existed but went undetected because of sampling and assay limitations; this possibility was ruled out with 95% certainty. These results indicate that SIVcpz is unevenly distributed among P. t. schweinfurthii in east Africa, with foci or hot spots of SIVcpz endemicity in some communities and rare or absent infection in others. This situation contrasts with that for smaller monkey species, in which infection rates by related SIVs are generally much higher and more uniform among different groups and populations. The basis for the wide variability in SIVcpz infection rates in east African apes and the important question of SIVcpz prevalence in west central African chimpanzees (Pan troglodytes troglodytes) remain to be elucidated." @default.
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- W2109597614 date "2003-07-01" @default.
- W2109597614 modified "2023-10-18" @default.
- W2109597614 title "Foci of Endemic Simian Immunodeficiency Virus Infection in Wild-Living Eastern Chimpanzees ( <i>Pan troglodytes schweinfurthii</i> )" @default.
- W2109597614 cites W1506969536 @default.
- W2109597614 cites W1563485932 @default.
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- W2109597614 cites W1889019185 @default.
- W2109597614 cites W1969535318 @default.
- W2109597614 cites W1978670876 @default.
- W2109597614 cites W1982703806 @default.
- W2109597614 cites W1982721121 @default.
- W2109597614 cites W1994485839 @default.
- W2109597614 cites W2000131964 @default.
- W2109597614 cites W2013023056 @default.
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- W2109597614 cites W201981122 @default.
- W2109597614 cites W2020927372 @default.
- W2109597614 cites W2031162756 @default.
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- W2109597614 cites W2096917893 @default.
- W2109597614 cites W2097706568 @default.
- W2109597614 cites W2098433844 @default.
- W2109597614 cites W2099138218 @default.
- W2109597614 cites W2099668460 @default.
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- W2109597614 cites W2115153266 @default.
- W2109597614 cites W2122502828 @default.
- W2109597614 cites W2138866629 @default.
- W2109597614 cites W2143746087 @default.
- W2109597614 cites W2150996958 @default.
- W2109597614 cites W2154963941 @default.
- W2109597614 cites W2157713905 @default.
- W2109597614 cites W2165032352 @default.
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- W2109597614 doi "https://doi.org/10.1128/jvi.77.13.7545-7562.2003" @default.
- W2109597614 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/164799" @default.
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