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- W2109602803 abstract "Imiquimod has been successfully used for treatment of various epithelial cutaneous neoplasms.Our aim was to evaluate the efficacy and tolerability of imiquimod 5% cream for treatment of Bowen's disease and invasive squamous cell carcinoma (SCC) in patients who were unsuitable candidates for surgery.Five Bowen's disease lesions and 7 invasive SCC lesions on 10 patients were treated with imiquimod once daily 5 times a week for a maximum of 16 weeks.After 8 to 12 weeks of treatment, 4 of 5 Bowen's disease lesions (80%) and 5 of 7 invasive SCCs (71.4%) showed complete clinicopathologic regression. The remaining 3 lesions showed partial regression after 16 weeks of treatment. No recurrence has been detected after a follow-up period of 24 to 38 months (mean, 31 months).The study is an open-label clinical trial on a small number of selected patients, with lack of excision with serial step sections.Topical application of imiquimod 5% cream might represent an alternative topical treatment to surgery in selected cases of Bowen's disease and invasive SCC." @default.
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- W2109602803 date "2006-08-01" @default.
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- W2109602803 title "Imiquimod 5% cream in the treatment of Bowen's disease and invasive squamous cell carcinoma" @default.
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- W2109602803 doi "https://doi.org/10.1016/j.jaad.2006.04.004" @default.
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