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- W2109612032 abstract "A massive and selective loss of CD4+ memory T cells occurs during the acute phase of immunodeficiency virus infections. The mechanism of this depletion is poorly understood but constitutes a key event with implications for progression. We assessed gene expression of purified T cells in Rhesus Macaques during acute SIVmac239 infection in order to define mechanisms of pathogenesis. We observe a general transcriptional program of over 1,600 interferon-stimulated genes induced in all T cells by the infection. Furthermore, we identify 113 transcriptional changes that are specific to virally infected cells. A striking downregulation of several key cell cycle regulator genes was observed and shared promotor-region E2F binding sites in downregulated genes suggested a targeted transcriptional control of an E2F regulated cell cycle program. In addition, the upregulation of the gene for the fundamental regulator of RNA polymerase II, TAF7, demonstrates that viral interference with the cell cycle and transcriptional regulation programs may be critical components during the establishment of a pathogenic infection in vivo." @default.
- W2109612032 created "2016-06-24" @default.
- W2109612032 creator A5051970389 @default.
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- W2109612032 creator A5074946587 @default.
- W2109612032 creator A5090939942 @default.
- W2109612032 creator A5091021327 @default.
- W2109612032 date "2011-10-17" @default.
- W2109612032 modified "2023-09-27" @default.
- W2109612032 title "The Simian Immunodeficiency Virus Targets Central Cell Cycle Functions through Transcriptional Repression In vivo" @default.
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- W2109612032 cites W1974393084 @default.
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- W2109612032 doi "https://doi.org/10.1371/journal.pone.0025684" @default.
- W2109612032 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3197176" @default.
- W2109612032 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22043290" @default.
- W2109612032 hasPublicationYear "2011" @default.
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