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- W2109615536 abstract "OBJECTIVE: The objective of this systematic review is to determine whether or not topical 1% pimecrolimus cream is an effective treatment for rosacea. STUDY DESIGN: Review of three English language primary studies published between 2007 and 2008. DATA SOURCES: Randomized, controlled, investigator-blind clinical trials comparing topical 1% pimecrolimus application to either placebo cream or an untreated portion of the face were found using OVID, MEDLINE, and Cochrane Databases. OUTCOMES MEASURED: Rosacea severity and improvement. Rosacea severity was assessed using the Rosacea Severity Score, set forth by the National Rosacea Society Expert Committee, which classifies the severity of erythema, papules, pustules, edema, and telangiectasia on a scale of 0 (no symptoms) to 3 (severe symptoms). Subjective severity scores were assigned using a visual analog scale (VAS) to assess rosacea severity on a scale of 0 (clear) to 5 (very severe). Rosacea severity was also assessed using a Subjective Severity Assessment (0-100 scale) and an investigators’ global assessment of erythema, papules, and total inflammatory lesions. RESULTS: Dichotomous data from the Karabulut et al. study did not show the use of topical 1% pimecrolimus cream to result in statistically significant improvement in rosacea severity, as measured by the Rosacea Severity Score, when compared to placebo cream. Dichotomous data presented by Lee et al. did not show statistically significant improvement in rosacea severity, as measured by investigators’ global assessment of erythema and papules. Dichotomous data from Weissenbacher et al. did not show statistically significant improvement in severity of clinical rosacea signs (erythema, papules, scaling, and pustules) as measured by the Rosacea Severity Score and the Subjective Severity Score after use of topical 1% pimecrolimus cream. CONCLUSIONS: Dichotomous data presented by Karabulut et al., Weissenbacher et al., and Lee et al. did not show the application of topical 1% pimecrolimus cream to cause statistically significant improvement in rosacea severity. Based on this finding, all three studies indicate that topical 1% pimecrolimus cream is not more efficacious in improving rosacea severity when compared to placebo cream or an untreated portion of the face." @default.
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- W2109615536 date "2011-01-01" @default.
- W2109615536 modified "2023-09-27" @default.
- W2109615536 title "Is Topical 1% Pimecrolimus Cream an Effective Treatment for Rosacea?" @default.
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