FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2109626360> ?p ?o ?g. }

• W2109626360 abstract "Childhood cancer survivors (CCSs) have an increased risk of morbidity and mortality. We evaluated the prevalence and determinants of left ventricular (LV) dysfunction in a large cohort of long-term CCSs treated with different potentially cardiotoxic therapies.The study cohort consisted of all adult 5-year CCSs who were treated with potentially cardiotoxic therapies and who visited our late effects outpatient clinic. Echocardiography was performed in patients who had received anthracyclines, cardiac irradiation, high-dose cyclophosphamide, or high-dose ifosfamide. Detailed treatment data were registered. Both multivariate linear and logistic regression analyses were performed.Of 601 eligible CCSs, 525 (87%) had an echocardiogram performed, of which 514 were evaluable for assessment of the LV shortening fraction (LVSF). The median overall LVSF in the whole group of CCSs was 33.1% (range, 13.0%-56.0%). Subclinical cardiac dysfunction (LVSF <30%) was identified in 139 patients (27%). In a multivariate linear regression model, LVSF was reduced with younger age at diagnosis, higher cumulative anthracycline dose, and radiation to the thorax. High-dose cyclophosphamide and ifosfamide were not associated with a reduction of LVSF. Vincristine sulfate was associated with a nonsignificant decrease of cardiac function (P = .07). Epirubicin hydrochloride was as cardiotoxic as doxorubicin when corrected for tumor efficacy, and daunorubicin hydrochloride seemed less cardiotoxic.A high percentage (27%) of young adult CCSs have an abnormal cardiac function. The strongest predictors of subclinical cardiac dysfunction are anthracycline dose, cardiac irradiation, and younger age at diagnosis. There is a suggestion that daunorubicin is less cardiotoxic than other anthracyclines." @default.
• W2109626360 created "2016-06-24" @default.
• W2109626360 creator A5000044097 @default.
• W2109626360 creator A5023591860 @default.
• W2109626360 creator A5028653037 @default.
• W2109626360 creator A5029704913 @default.
• W2109626360 creator A5030601121 @default.
• W2109626360 creator A5041206659 @default.
• W2109626360 creator A5053197149 @default.
• W2109626360 creator A5065228177 @default.
• W2109626360 creator A5084943918 @default.
• W2109626360 creator A5089588265 @default.
• W2109626360 date "2010-07-26" @default.
• W2109626360 modified "2023-10-02" @default.
• W2109626360 title "Cardiac Function in 5-Year Survivors of Childhood Cancer" @default.
• W2109626360 cites W1506846450 @default.
• W2109626360 cites W1888095354 @default.
• W2109626360 cites W1894979576 @default.
• W2109626360 cites W1913539970 @default.
• W2109626360 cites W1916063969 @default.
• W2109626360 cites W1976347407 @default.
• W2109626360 cites W1987585800 @default.
• W2109626360 cites W2003943979 @default.
• W2109626360 cites W2010368866 @default.
• W2109626360 cites W2013012230 @default.
• W2109626360 cites W2015758016 @default.
• W2109626360 cites W2021407982 @default.
• W2109626360 cites W2024136031 @default.
• W2109626360 cites W2030492523 @default.
• W2109626360 cites W2038882124 @default.
• W2109626360 cites W2044934343 @default.
• W2109626360 cites W2066617715 @default.
• W2109626360 cites W2068885257 @default.
• W2109626360 cites W2075713027 @default.
• W2109626360 cites W2098831024 @default.
• W2109626360 cites W2100542659 @default.
• W2109626360 cites W2118715207 @default.
• W2109626360 cites W2120321741 @default.
• W2109626360 cites W2121797481 @default.
• W2109626360 cites W2123870033 @default.
• W2109626360 cites W2123885366 @default.
• W2109626360 cites W2144410376 @default.
• W2109626360 cites W2148071840 @default.
• W2109626360 cites W2150719401 @default.
• W2109626360 cites W2157134137 @default.
• W2109626360 cites W2160328538 @default.
• W2109626360 cites W2161082810 @default.
• W2109626360 cites W2161776889 @default.
• W2109626360 cites W2172202131 @default.
• W2109626360 cites W2265230738 @default.
• W2109626360 cites W2469805673 @default.
• W2109626360 cites W2585382523 @default.
• W2109626360 cites W431041432 @default.
• W2109626360 doi "https://doi.org/10.1001/archinternmed.2010.233" @default.
• W2109626360 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20660845" @default.
• W2109626360 hasPublicationYear "2010" @default.
• W2109626360 type Work @default.
• W2109626360 sameAs 2109626360 @default.
• W2109626360 citedByCount "149" @default.
• W2109626360 countsByYear W21096263602012 @default.
• W2109626360 countsByYear W21096263602013 @default.
• W2109626360 countsByYear W21096263602014 @default.
• W2109626360 countsByYear W21096263602015 @default.
• W2109626360 countsByYear W21096263602016 @default.
• W2109626360 countsByYear W21096263602017 @default.
• W2109626360 countsByYear W21096263602018 @default.
• W2109626360 countsByYear W21096263602019 @default.
• W2109626360 countsByYear W21096263602020 @default.
• W2109626360 countsByYear W21096263602021 @default.
• W2109626360 countsByYear W21096263602022 @default.
• W2109626360 countsByYear W21096263602023 @default.
• W2109626360 crossrefType "journal-article" @default.
• W2109626360 hasAuthorship W2109626360A5000044097 @default.
• W2109626360 hasAuthorship W2109626360A5023591860 @default.
• W2109626360 hasAuthorship W2109626360A5028653037 @default.
• W2109626360 hasAuthorship W2109626360A5029704913 @default.
• W2109626360 hasAuthorship W2109626360A5030601121 @default.
• W2109626360 hasAuthorship W2109626360A5041206659 @default.
• W2109626360 hasAuthorship W2109626360A5053197149 @default.
• W2109626360 hasAuthorship W2109626360A5065228177 @default.
• W2109626360 hasAuthorship W2109626360A5084943918 @default.
• W2109626360 hasAuthorship W2109626360A5089588265 @default.
• W2109626360 hasConcept C111566952 @default.
• W2109626360 hasConcept C113280763 @default.
• W2109626360 hasConcept C121608353 @default.
• W2109626360 hasConcept C126322002 @default.
• W2109626360 hasConcept C141071460 @default.
• W2109626360 hasConcept C151032500 @default.
• W2109626360 hasConcept C164705383 @default.
• W2109626360 hasConcept C2776694085 @default.
• W2109626360 hasConcept C2776755627 @default.
• W2109626360 hasConcept C2776802502 @default.
• W2109626360 hasConcept C2777506904 @default.
• W2109626360 hasConcept C2778119113 @default.
• W2109626360 hasConcept C2778198053 @default.
• W2109626360 hasConcept C2778233292 @default.
• W2109626360 hasConcept C2780376820 @default.
• W2109626360 hasConcept C2780835546 @default.
• W2109626360 hasConcept C530470458 @default.
• W2109626360 hasConcept C71924100 @default.

• next