FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2109634336> ?p ?o ?g. }

• W2109634336 endingPage "1206" @default.
• W2109634336 startingPage "1195" @default.
• W2109634336 abstract "Distension‐sensitive vagal afferent fibres from the guinea‐pig oesophagus were recorded extracellularly in vitro . Most recorded units were spontaneously active firing at 3.2±0.3 Hz ( n =41, N =41) and had low thresholds (less than 1 mm) to circumferential stretch. Dynamic and adapted phases of stretch‐evoked firing, as well as a silent period were linearly dependent on the amplitude of stretch. High K + (7–12 m M ) Krebs solution dose‐dependently increased both spontaneous and stretch‐evoked firing and reduced the duration of the silent period. Charybdotoxin (ChTX, 100 n M ) slightly increased spontaneous and stretch‐evoked firing and decreased the silent period, while neither iberiotoxin (100 n M ) nor apamin (0.5 μ M ) had significant effects. ω‐Conotoxin GVIA (0.5 μ M ) did not significantly affect firing of vagal mechanoreceptors. In the majority of single units, 4‐aminopyridine (4‐AP) concentration‐dependently (EC 50 ∼28 μ M ) increased spontaneous firing, strongly reduced the silent period but did not affect stretch (3 mm)‐induced firing. Firing evoked by 1–2 mm was increased by 4‐AP. α‐Dendrotoxin (DnTX, 300 n M ) and DnTX K (30 n M ) slightly increased spontaneous and stretch‐evoked firing. There was no additive effect on spontaneous firing when ChTX and DnTX K were applied simultaneously. Barium (100 μ M ) increased stretch‐induced firing, probably due to an increase in intramural tension. Glibenclamide (10 μ M ) had no effect on spontaneous or stretch‐induced firing. The results indicate that voltage‐gated 4‐AP‐ and dendrotoxin‐sensitive K + channels are the main type of K + channels that influence excitability of vagal mechano‐sensitive endings of the guinea‐pig oesophagus. They were involved in control of spontaneous firing and in stretch‐induced firing evoked by moderate stretch, but none of the K + channels appeared to be involved in adaptation to maintained stretch by their slowly adapting vagal mechanoreceptors. British Journal of Pharmacology (2002) 137 , 1195–1206. doi: 10.1038/sj.bjp.0704964" @default.
• W2109634336 created "2016-06-24" @default.
• W2109634336 creator A5018041871 @default.
• W2109634336 creator A5019583844 @default.
• W2109634336 creator A5026220105 @default.
• W2109634336 creator A5052605602 @default.
• W2109634336 date "2002-12-01" @default.
• W2109634336 modified "2023-09-29" @default.
• W2109634336 title "4-aminopyridine- and dendrotoxin-sensitive potassium channels influence excitability of vagal mechano-sensitive endings in guinea-pig oesophagus" @default.
• W2109634336 cites W1730174749 @default.
• W2109634336 cites W1904956466 @default.
• W2109634336 cites W1966644204 @default.
• W2109634336 cites W1972679916 @default.
• W2109634336 cites W1981761340 @default.
• W2109634336 cites W1986780243 @default.
• W2109634336 cites W1990709131 @default.
• W2109634336 cites W2002500727 @default.
• W2109634336 cites W2003082472 @default.
• W2109634336 cites W2009306228 @default.
• W2109634336 cites W2014659891 @default.
• W2109634336 cites W2024333046 @default.
• W2109634336 cites W2030245254 @default.
• W2109634336 cites W2036257997 @default.
• W2109634336 cites W2046878369 @default.
• W2109634336 cites W2047439107 @default.
• W2109634336 cites W2050135503 @default.
• W2109634336 cites W2050917547 @default.
• W2109634336 cites W2066118083 @default.
• W2109634336 cites W2070015190 @default.
• W2109634336 cites W2071424437 @default.
• W2109634336 cites W2076910299 @default.
• W2109634336 cites W2079441999 @default.
• W2109634336 cites W2080065616 @default.
• W2109634336 cites W2086331804 @default.
• W2109634336 cites W2133933408 @default.
• W2109634336 cites W2144437938 @default.
• W2109634336 cites W2225255522 @default.
• W2109634336 cites W2395513110 @default.
• W2109634336 doi "https://doi.org/10.1038/sj.bjp.0704964" @default.
• W2109634336 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1573601" @default.
• W2109634336 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12466228" @default.
• W2109634336 hasPublicationYear "2002" @default.
• W2109634336 type Work @default.
• W2109634336 sameAs 2109634336 @default.
• W2109634336 citedByCount "15" @default.
• W2109634336 countsByYear W21096343362019 @default.
• W2109634336 countsByYear W21096343362021 @default.
• W2109634336 crossrefType "journal-article" @default.
• W2109634336 hasAuthorship W2109634336A5018041871 @default.
• W2109634336 hasAuthorship W2109634336A5019583844 @default.
• W2109634336 hasAuthorship W2109634336A5026220105 @default.
• W2109634336 hasAuthorship W2109634336A5052605602 @default.
• W2109634336 hasBestOaLocation W21096343362 @default.
• W2109634336 hasConcept C105702510 @default.
• W2109634336 hasConcept C12554922 @default.
• W2109634336 hasConcept C181911157 @default.
• W2109634336 hasConcept C185592680 @default.
• W2109634336 hasConcept C2776919887 @default.
• W2109634336 hasConcept C2779411790 @default.
• W2109634336 hasConcept C2780419564 @default.
• W2109634336 hasConcept C2780922449 @default.
• W2109634336 hasConcept C42219234 @default.
• W2109634336 hasConcept C55493867 @default.
• W2109634336 hasConcept C71924100 @default.
• W2109634336 hasConcept C83743174 @default.
• W2109634336 hasConcept C86803240 @default.
• W2109634336 hasConceptScore W2109634336C105702510 @default.
• W2109634336 hasConceptScore W2109634336C12554922 @default.
• W2109634336 hasConceptScore W2109634336C181911157 @default.
• W2109634336 hasConceptScore W2109634336C185592680 @default.
• W2109634336 hasConceptScore W2109634336C2776919887 @default.
• W2109634336 hasConceptScore W2109634336C2779411790 @default.
• W2109634336 hasConceptScore W2109634336C2780419564 @default.
• W2109634336 hasConceptScore W2109634336C2780922449 @default.
• W2109634336 hasConceptScore W2109634336C42219234 @default.
• W2109634336 hasConceptScore W2109634336C55493867 @default.
• W2109634336 hasConceptScore W2109634336C71924100 @default.
• W2109634336 hasConceptScore W2109634336C83743174 @default.
• W2109634336 hasConceptScore W2109634336C86803240 @default.
• W2109634336 hasIssue "8" @default.
• W2109634336 hasLocation W21096343361 @default.
• W2109634336 hasLocation W21096343362 @default.
• W2109634336 hasLocation W21096343363 @default.
• W2109634336 hasLocation W21096343364 @default.
• W2109634336 hasOpenAccess W2109634336 @default.
• W2109634336 hasPrimaryLocation W21096343361 @default.
• W2109634336 hasRelatedWork W2001072936 @default.
• W2109634336 hasRelatedWork W2002591410 @default.
• W2109634336 hasRelatedWork W2004883803 @default.
• W2109634336 hasRelatedWork W2033243150 @default.
• W2109634336 hasRelatedWork W2041171730 @default.
• W2109634336 hasRelatedWork W2045400413 @default.
• W2109634336 hasRelatedWork W2161661722 @default.
• W2109634336 hasRelatedWork W2162655920 @default.
• W2109634336 hasRelatedWork W2312672762 @default.
• W2109634336 hasRelatedWork W2419342829 @default.
• W2109634336 hasVolume "137" @default.
• W2109634336 isParatext "false" @default.

• next