FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2109652445> ?p ?o ?g. }

• W2109652445 endingPage "538" @default.
• W2109652445 startingPage "529" @default.
• W2109652445 abstract "BackgroundStenting is an alternative to endarterectomy for treatment of carotid artery stenosis, but long-term efficacy is uncertain. We report long-term data from the randomised International Carotid Stenting Study comparison of these treatments.MethodsPatients with symptomatic carotid stenosis were randomly assigned 1:1 to open treatment with stenting or endarterectomy at 50 centres worldwide. Randomisation was computer generated centrally and allocated by telephone call or fax. Major outcomes were assessed by an independent endpoint committee unaware of treatment assignment. The primary endpoint was fatal or disabling stroke in any territory after randomisation to the end of follow-up. Analysis was by intention to treat ([ITT] all patients) and per protocol from 31 days after treatment (all patients in whom assigned treatment was completed). Functional ability was rated with the modified Rankin scale. This study is registered, number ISRCTN25337470.Findings1713 patients were assigned to stenting (n=855) or endarterectomy (n=858) and followed up for a median of 4·2 years (IQR 3·0–5·2, maximum 10·0). Three patients withdrew immediately and, therefore, the ITT population comprised 1710 patients. The number of fatal or disabling strokes (52 vs 49) and cumulative 5-year risk did not differ significantly between the stenting and endarterectomy groups (6·4% vs 6·5%; hazard ratio [HR] 1·06, 95% CI 0·72–1·57, p=0·77). Any stroke was more frequent in the stenting group than in the endarterectomy group (119 vs 72 events; ITT population, 5-year cumulative risk 15·2% vs 9·4%, HR 1·71, 95% CI 1·28–2·30, p<0·001; per-protocol population, 5-year cumulative risk 8·9% vs 5·8%, 1·53, 1·02–2·31, p=0·04), but were mainly non-disabling strokes. The distribution of modified Rankin scale scores at 1 year, 5 years, or final follow-up did not differ significantly between treatment groups.InterpretationLong-term functional outcome and risk of fatal or disabling stroke are similar for stenting and endarterectomy for symptomatic carotid stenosis.FundingMedical Research Council, Stroke Association, Sanofi-Synthélabo, European Union. Stenting is an alternative to endarterectomy for treatment of carotid artery stenosis, but long-term efficacy is uncertain. We report long-term data from the randomised International Carotid Stenting Study comparison of these treatments. Patients with symptomatic carotid stenosis were randomly assigned 1:1 to open treatment with stenting or endarterectomy at 50 centres worldwide. Randomisation was computer generated centrally and allocated by telephone call or fax. Major outcomes were assessed by an independent endpoint committee unaware of treatment assignment. The primary endpoint was fatal or disabling stroke in any territory after randomisation to the end of follow-up. Analysis was by intention to treat ([ITT] all patients) and per protocol from 31 days after treatment (all patients in whom assigned treatment was completed). Functional ability was rated with the modified Rankin scale. This study is registered, number ISRCTN25337470. 1713 patients were assigned to stenting (n=855) or endarterectomy (n=858) and followed up for a median of 4·2 years (IQR 3·0–5·2, maximum 10·0). Three patients withdrew immediately and, therefore, the ITT population comprised 1710 patients. The number of fatal or disabling strokes (52 vs 49) and cumulative 5-year risk did not differ significantly between the stenting and endarterectomy groups (6·4% vs 6·5%; hazard ratio [HR] 1·06, 95% CI 0·72–1·57, p=0·77). Any stroke was more frequent in the stenting group than in the endarterectomy group (119 vs 72 events; ITT population, 5-year cumulative risk 15·2% vs 9·4%, HR 1·71, 95% CI 1·28–2·30, p<0·001; per-protocol population, 5-year cumulative risk 8·9% vs 5·8%, 1·53, 1·02–2·31, p=0·04), but were mainly non-disabling strokes. The distribution of modified Rankin scale scores at 1 year, 5 years, or final follow-up did not differ significantly between treatment groups. Long-term functional outcome and risk of fatal or disabling stroke are similar for stenting and endarterectomy for symptomatic carotid stenosis." @default.
• W2109652445 created "2016-06-24" @default.
• W2109652445 creator A5002504004 @default.
• W2109652445 creator A5020024962 @default.
• W2109652445 creator A5020097116 @default.
• W2109652445 creator A5022196917 @default.
• W2109652445 creator A5035137084 @default.
• W2109652445 creator A5038105680 @default.
• W2109652445 creator A5041701048 @default.
• W2109652445 creator A5042145465 @default.
• W2109652445 creator A5045084521 @default.
• W2109652445 creator A5057675631 @default.
• W2109652445 creator A5060474778 @default.
• W2109652445 creator A5064918196 @default.
• W2109652445 creator A5069064131 @default.
• W2109652445 creator A5075785208 @default.
• W2109652445 date "2015-02-01" @default.
• W2109652445 modified "2023-10-06" @default.
• W2109652445 title "Long-term outcomes after stenting versus endarterectomy for treatment of symptomatic carotid stenosis: the International Carotid Stenting Study (ICSS) randomised trial" @default.
• W2109652445 cites W1506959497 @default.
• W2109652445 cites W154941835 @default.
• W2109652445 cites W1969661146 @default.
• W2109652445 cites W1997663201 @default.
• W2109652445 cites W1998066022 @default.
• W2109652445 cites W2029088929 @default.
• W2109652445 cites W2041685243 @default.
• W2109652445 cites W2097075190 @default.
• W2109652445 cites W2097554249 @default.
• W2109652445 cites W2100194095 @default.
• W2109652445 cites W2118383837 @default.
• W2109652445 cites W2122528416 @default.
• W2109652445 cites W2122743334 @default.
• W2109652445 cites W2124820341 @default.
• W2109652445 cites W2128749853 @default.
• W2109652445 cites W2135353076 @default.
• W2109652445 cites W2140862373 @default.
• W2109652445 cites W2146237298 @default.
• W2109652445 cites W2152641052 @default.
• W2109652445 cites W2154447272 @default.
• W2109652445 cites W2159792896 @default.
• W2109652445 cites W2612334191 @default.
• W2109652445 cites W2767911074 @default.
• W2109652445 cites W4296424071 @default.
• W2109652445 doi "https://doi.org/10.1016/s0140-6736(14)61184-3" @default.
• W2109652445 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4322188" @default.
• W2109652445 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25453443" @default.
• W2109652445 hasPublicationYear "2015" @default.
• W2109652445 type Work @default.
• W2109652445 sameAs 2109652445 @default.
• W2109652445 citedByCount "396" @default.
• W2109652445 countsByYear W21096524452014 @default.
• W2109652445 countsByYear W21096524452015 @default.
• W2109652445 countsByYear W21096524452016 @default.
• W2109652445 countsByYear W21096524452017 @default.
• W2109652445 countsByYear W21096524452018 @default.
• W2109652445 countsByYear W21096524452019 @default.
• W2109652445 countsByYear W21096524452020 @default.
• W2109652445 countsByYear W21096524452021 @default.
• W2109652445 countsByYear W21096524452022 @default.
• W2109652445 countsByYear W21096524452023 @default.
• W2109652445 crossrefType "journal-article" @default.
• W2109652445 hasAuthorship W2109652445A5002504004 @default.
• W2109652445 hasAuthorship W2109652445A5020024962 @default.
• W2109652445 hasAuthorship W2109652445A5020097116 @default.
• W2109652445 hasAuthorship W2109652445A5022196917 @default.
• W2109652445 hasAuthorship W2109652445A5035137084 @default.
• W2109652445 hasAuthorship W2109652445A5038105680 @default.
• W2109652445 hasAuthorship W2109652445A5041701048 @default.
• W2109652445 hasAuthorship W2109652445A5042145465 @default.
• W2109652445 hasAuthorship W2109652445A5045084521 @default.
• W2109652445 hasAuthorship W2109652445A5057675631 @default.
• W2109652445 hasAuthorship W2109652445A5060474778 @default.
• W2109652445 hasAuthorship W2109652445A5064918196 @default.
• W2109652445 hasAuthorship W2109652445A5069064131 @default.
• W2109652445 hasAuthorship W2109652445A5075785208 @default.
• W2109652445 hasBestOaLocation W21096524452 @default.
• W2109652445 hasConcept C126322002 @default.
• W2109652445 hasConcept C127413603 @default.
• W2109652445 hasConcept C141071460 @default.
• W2109652445 hasConcept C168563851 @default.
• W2109652445 hasConcept C202953159 @default.
• W2109652445 hasConcept C203092338 @default.
• W2109652445 hasConcept C207103383 @default.
• W2109652445 hasConcept C2779169563 @default.
• W2109652445 hasConcept C2779745121 @default.
• W2109652445 hasConcept C2780007028 @default.
• W2109652445 hasConcept C2780645631 @default.
• W2109652445 hasConcept C2780931571 @default.
• W2109652445 hasConcept C2781068581 @default.
• W2109652445 hasConcept C2908647359 @default.
• W2109652445 hasConcept C3020199598 @default.
• W2109652445 hasConcept C44249647 @default.
• W2109652445 hasConcept C541997718 @default.
• W2109652445 hasConcept C71924100 @default.
• W2109652445 hasConcept C78519656 @default.
• W2109652445 hasConcept C99454951 @default.
• W2109652445 hasConceptScore W2109652445C126322002 @default.
• W2109652445 hasConceptScore W2109652445C127413603 @default.

• next