FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2109664062> ?p ?o ?g. }

• W2109664062 endingPage "1118" @default.
• W2109664062 startingPage "1112" @default.
• W2109664062 abstract "Aim: Recent evidence suggests that protein degradation system autophagy is implicated in a component of innate immunity. We report here that suppression of autophagy in Kupffer cells due to hepatic steatosis enhances an inflammatory response to endotoxin. Methods: Kupffer cells were isolated from C57BL/6J mice fed chow diet (control) or high‐fat diet (HFD) for 12 weeks, liver‐specific autophagy‐deficient mice (Atg7 F/F :Mx1‐Cre) and wild‐type mice (Atg7 F/F ). Kupffer cells were incubated with 100 ng/mL lipopolysaccharide (LPS). The concentration of tumor necrosis factor (TNF)‐α in media was measured by enzyme‐linked immunoassay. Expression of Toll‐like receptor (TLR)4, IκB kinase (IKK)‐α/β, p38, p62 and LC3 in Kupffer cells was evaluated by western blot analysis. Results: Incubation with LPS increased LC3‐II expression of Kupffer cells from control mice; however, an increase in LC3‐II expression due to LPS was suppressed in Kupffer cells from HFD mice. Moreover, both p62 expression and TNF‐α production in Kupffer cells from HFD mice was higher than control mice. On the other hand, LPS exposure increased TNF‐α production from autophagy‐deficient Kupffer cells more than wild type. There was no significant difference in expression of TLR4 between wild and autophagy‐deficient Kupffer cells. Nevertheless, activation of p38 or IKK in Kupffer cells due to LPS was augmented by autophagy deficiency. The addition of the p38 inhibitor SB203580 attenuated TNF‐α production in both wild and autophagy‐deficient Kupffer cells. Conclusion: These results suggest that suppression of autophagy observed in Kupffer cells from steatotic liver sensitizes to endotoxin. In conclusion, suppression of autophagy may play a pivotal role on progression of NAFLD." @default.
• W2109664062 created "2016-06-24" @default.
• W2109664062 creator A5000759996 @default.
• W2109664062 creator A5024546865 @default.
• W2109664062 creator A5024568340 @default.
• W2109664062 creator A5025748633 @default.
• W2109664062 creator A5040426310 @default.
• W2109664062 creator A5053599358 @default.
• W2109664062 creator A5079586020 @default.
• W2109664062 date "2012-05-14" @default.
• W2109664062 modified "2023-10-17" @default.
• W2109664062 title "Suppression of autophagy sensitizes Kupffer cells to endotoxin" @default.
• W2109664062 cites W12451109 @default.
• W2109664062 cites W1968989583 @default.
• W2109664062 cites W1978751572 @default.
• W2109664062 cites W1988327539 @default.
• W2109664062 cites W1988358352 @default.
• W2109664062 cites W1991300803 @default.
• W2109664062 cites W1994823455 @default.
• W2109664062 cites W1996809518 @default.
• W2109664062 cites W1998156781 @default.
• W2109664062 cites W2000691137 @default.
• W2109664062 cites W2014700733 @default.
• W2109664062 cites W2017730825 @default.
• W2109664062 cites W2034172998 @default.
• W2109664062 cites W2043775908 @default.
• W2109664062 cites W2046074477 @default.
• W2109664062 cites W2055112613 @default.
• W2109664062 cites W2057623698 @default.
• W2109664062 cites W2064741210 @default.
• W2109664062 cites W2069952533 @default.
• W2109664062 cites W2075783257 @default.
• W2109664062 cites W2079569342 @default.
• W2109664062 cites W2090879914 @default.
• W2109664062 cites W2096853390 @default.
• W2109664062 cites W2124639982 @default.
• W2109664062 cites W2137835350 @default.
• W2109664062 cites W2138497055 @default.
• W2109664062 cites W2146887271 @default.
• W2109664062 cites W2150679087 @default.
• W2109664062 cites W2157778451 @default.
• W2109664062 cites W2164567049 @default.
• W2109664062 cites W2314673390 @default.
• W2109664062 doi "https://doi.org/10.1111/j.1872-034x.2012.01024.x" @default.
• W2109664062 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22583683" @default.
• W2109664062 hasPublicationYear "2012" @default.
• W2109664062 type Work @default.
• W2109664062 sameAs 2109664062 @default.
• W2109664062 citedByCount "22" @default.
• W2109664062 countsByYear W21096640622013 @default.
• W2109664062 countsByYear W21096640622014 @default.
• W2109664062 countsByYear W21096640622015 @default.
• W2109664062 countsByYear W21096640622016 @default.
• W2109664062 countsByYear W21096640622017 @default.
• W2109664062 countsByYear W21096640622018 @default.
• W2109664062 countsByYear W21096640622019 @default.
• W2109664062 countsByYear W21096640622021 @default.
• W2109664062 countsByYear W21096640622022 @default.
• W2109664062 countsByYear W21096640622023 @default.
• W2109664062 crossrefType "journal-article" @default.
• W2109664062 hasAuthorship W2109664062A5000759996 @default.
• W2109664062 hasAuthorship W2109664062A5024546865 @default.
• W2109664062 hasAuthorship W2109664062A5024568340 @default.
• W2109664062 hasAuthorship W2109664062A5025748633 @default.
• W2109664062 hasAuthorship W2109664062A5040426310 @default.
• W2109664062 hasAuthorship W2109664062A5053599358 @default.
• W2109664062 hasAuthorship W2109664062A5079586020 @default.
• W2109664062 hasConcept C104317684 @default.
• W2109664062 hasConcept C126322002 @default.
• W2109664062 hasConcept C134018914 @default.
• W2109664062 hasConcept C153911025 @default.
• W2109664062 hasConcept C17991360 @default.
• W2109664062 hasConcept C181199279 @default.
• W2109664062 hasConcept C185592680 @default.
• W2109664062 hasConcept C190283241 @default.
• W2109664062 hasConcept C203014093 @default.
• W2109664062 hasConcept C203522944 @default.
• W2109664062 hasConcept C2776070231 @default.
• W2109664062 hasConcept C2776415932 @default.
• W2109664062 hasConcept C2776914184 @default.
• W2109664062 hasConcept C2778754761 @default.
• W2109664062 hasConcept C2778904781 @default.
• W2109664062 hasConcept C2780216420 @default.
• W2109664062 hasConcept C55493867 @default.
• W2109664062 hasConcept C71924100 @default.
• W2109664062 hasConcept C86803240 @default.
• W2109664062 hasConceptScore W2109664062C104317684 @default.
• W2109664062 hasConceptScore W2109664062C126322002 @default.
• W2109664062 hasConceptScore W2109664062C134018914 @default.
• W2109664062 hasConceptScore W2109664062C153911025 @default.
• W2109664062 hasConceptScore W2109664062C17991360 @default.
• W2109664062 hasConceptScore W2109664062C181199279 @default.
• W2109664062 hasConceptScore W2109664062C185592680 @default.
• W2109664062 hasConceptScore W2109664062C190283241 @default.
• W2109664062 hasConceptScore W2109664062C203014093 @default.
• W2109664062 hasConceptScore W2109664062C203522944 @default.
• W2109664062 hasConceptScore W2109664062C2776070231 @default.
• W2109664062 hasConceptScore W2109664062C2776415932 @default.

• next