Matches in SemOpenAlex for { <https://semopenalex.org/work/W2109668527> ?p ?o ?g. }
- W2109668527 endingPage "3986" @default.
- W2109668527 startingPage "3975" @default.
- W2109668527 abstract "Myotendinous strain injury is the most common injury of human skeletal muscles because the majority of muscle forces are transmitted through this region. Although the immediate response to strain injury is well characterized, the chronic response to myotendinous strain injury is less clear. Here we examined the molecular and cellular adaptations to chronic myotendinous strain injury in mdx mice expressing a microdystrophin transgene (microdystrophinΔR4–R23). We found that muscles with myotendinous strain injury had an increased expression of utrophin and α7-integrin together with the dramatic restructuring of peripheral myofibrils into concentric rings. The sarcolemma of the microdystrophinΔR4–R23/mdx gastrocnemius muscles was highly protected from experimental lengthening contractions, better than wild-type muscles. We also found a positive correlation between myotendinous strain injury and ringed fibers in the HSALR (human skeletal actin, long repeat) mouse model of myotonic dystrophy. We suggest that changes in protein expression and the formation of rings are adaptations to myotendinous strain injury that help to prevent muscle necrosis and retain the function of necessary muscles during injury, ageing and disease." @default.
- W2109668527 created "2016-06-24" @default.
- W2109668527 creator A5032235028 @default.
- W2109668527 creator A5039626465 @default.
- W2109668527 creator A5058539735 @default.
- W2109668527 creator A5074184887 @default.
- W2109668527 date "2008-09-16" @default.
- W2109668527 modified "2023-10-09" @default.
- W2109668527 title "Molecular and cellular adaptations to chronic myotendinous strain injury in mdx mice expressing a truncated dystrophin" @default.
- W2109668527 cites W140598396 @default.
- W2109668527 cites W1893151759 @default.
- W2109668527 cites W1899737965 @default.
- W2109668527 cites W1943341903 @default.
- W2109668527 cites W1965187379 @default.
- W2109668527 cites W1965883224 @default.
- W2109668527 cites W1966493859 @default.
- W2109668527 cites W1967261851 @default.
- W2109668527 cites W1975141179 @default.
- W2109668527 cites W1975611030 @default.
- W2109668527 cites W1976636905 @default.
- W2109668527 cites W1976919537 @default.
- W2109668527 cites W1983836253 @default.
- W2109668527 cites W1995128238 @default.
- W2109668527 cites W1999008715 @default.
- W2109668527 cites W2001835321 @default.
- W2109668527 cites W2007790958 @default.
- W2109668527 cites W2009046675 @default.
- W2109668527 cites W2009372610 @default.
- W2109668527 cites W2018600945 @default.
- W2109668527 cites W2019563312 @default.
- W2109668527 cites W2021259180 @default.
- W2109668527 cites W2026862295 @default.
- W2109668527 cites W2032097547 @default.
- W2109668527 cites W2037305406 @default.
- W2109668527 cites W2041748795 @default.
- W2109668527 cites W2044964290 @default.
- W2109668527 cites W2055694197 @default.
- W2109668527 cites W2058140775 @default.
- W2109668527 cites W2062056760 @default.
- W2109668527 cites W2066190445 @default.
- W2109668527 cites W2073377967 @default.
- W2109668527 cites W2076024089 @default.
- W2109668527 cites W2081748748 @default.
- W2109668527 cites W2093778475 @default.
- W2109668527 cites W2100739329 @default.
- W2109668527 cites W2109727703 @default.
- W2109668527 cites W2115673829 @default.
- W2109668527 cites W2119812021 @default.
- W2109668527 cites W2122679390 @default.
- W2109668527 cites W2128349044 @default.
- W2109668527 cites W2131333364 @default.
- W2109668527 cites W2137244200 @default.
- W2109668527 cites W2140477606 @default.
- W2109668527 cites W2148034459 @default.
- W2109668527 cites W2148349633 @default.
- W2109668527 cites W2163182146 @default.
- W2109668527 cites W2167756999 @default.
- W2109668527 cites W2172287346 @default.
- W2109668527 cites W2292568679 @default.
- W2109668527 cites W3023475953 @default.
- W2109668527 cites W92319764 @default.
- W2109668527 doi "https://doi.org/10.1093/hmg/ddn301" @default.
- W2109668527 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2638580" @default.
- W2109668527 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18799475" @default.
- W2109668527 hasPublicationYear "2008" @default.
- W2109668527 type Work @default.
- W2109668527 sameAs 2109668527 @default.
- W2109668527 citedByCount "36" @default.
- W2109668527 countsByYear W21096685272012 @default.
- W2109668527 countsByYear W21096685272013 @default.
- W2109668527 countsByYear W21096685272014 @default.
- W2109668527 countsByYear W21096685272015 @default.
- W2109668527 countsByYear W21096685272016 @default.
- W2109668527 countsByYear W21096685272017 @default.
- W2109668527 countsByYear W21096685272018 @default.
- W2109668527 countsByYear W21096685272019 @default.
- W2109668527 countsByYear W21096685272020 @default.
- W2109668527 countsByYear W21096685272022 @default.
- W2109668527 countsByYear W21096685272023 @default.
- W2109668527 crossrefType "journal-article" @default.
- W2109668527 hasAuthorship W2109668527A5032235028 @default.
- W2109668527 hasAuthorship W2109668527A5039626465 @default.
- W2109668527 hasAuthorship W2109668527A5058539735 @default.
- W2109668527 hasAuthorship W2109668527A5074184887 @default.
- W2109668527 hasBestOaLocation W21096685271 @default.
- W2109668527 hasConcept C105702510 @default.
- W2109668527 hasConcept C125705527 @default.
- W2109668527 hasConcept C134018914 @default.
- W2109668527 hasConcept C199096232 @default.
- W2109668527 hasConcept C207200792 @default.
- W2109668527 hasConcept C2778022156 @default.
- W2109668527 hasConcept C2778750056 @default.
- W2109668527 hasConcept C2778943923 @default.
- W2109668527 hasConcept C2779030066 @default.
- W2109668527 hasConcept C2779959927 @default.
- W2109668527 hasConcept C2780394045 @default.
- W2109668527 hasConcept C54355233 @default.
- W2109668527 hasConcept C68731436 @default.