Matches in SemOpenAlex for { <https://semopenalex.org/work/W2109673410> ?p ?o ?g. }
- W2109673410 endingPage "4194" @default.
- W2109673410 startingPage "4186" @default.
- W2109673410 abstract "ABSTRACT Urinary tract infection (UTI) is most often caused by uropathogenic Escherichia coli (UPEC). UPEC inoculation into the female urinary tract (UT) can occur through physical activities that expose the UT to an inherently polymicrobial periurethral, vaginal, or gastrointestinal flora. We report that a common urogenital inhabitant and opportunistic pathogen, group B Streptococcus (GBS), when present at the time of UPEC exposure, undergoes rapid UPEC-dependent exclusion from the murine urinary tract, yet it influences acute UPEC-host interactions and alters host susceptibility to persistent outcomes of bladder and kidney infection. GBS presence results in increased UPEC titers in the bladder lumen during acute infection and reduced inflammatory responses of murine macrophages to live UPEC or purified lipopolysaccharide (LPS), phenotypes that require GBS mimicry of host sialic acid residues. Taken together, these studies suggest that despite low titers, the presence of GBS at the time of polymicrobial UT exposure may be an overlooked risk factor for chronic pyelonephritis and recurrent UTI in susceptible groups, even if it is outcompeted and thus absent by the time of diagnosis." @default.
- W2109673410 created "2016-06-24" @default.
- W2109673410 creator A5025123956 @default.
- W2109673410 creator A5035728249 @default.
- W2109673410 creator A5039769184 @default.
- W2109673410 creator A5062322263 @default.
- W2109673410 creator A5075458614 @default.
- W2109673410 date "2012-12-01" @default.
- W2109673410 modified "2023-10-16" @default.
- W2109673410 title "Immune Modulation by Group B Streptococcus Influences Host Susceptibility to Urinary Tract Infection by Uropathogenic Escherichia coli" @default.
- W2109673410 cites W1502075862 @default.
- W2109673410 cites W1521822265 @default.
- W2109673410 cites W1699912176 @default.
- W2109673410 cites W1827320070 @default.
- W2109673410 cites W1868199019 @default.
- W2109673410 cites W1944764467 @default.
- W2109673410 cites W1975793951 @default.
- W2109673410 cites W1978926805 @default.
- W2109673410 cites W1980914602 @default.
- W2109673410 cites W1998801248 @default.
- W2109673410 cites W1999462217 @default.
- W2109673410 cites W2005766109 @default.
- W2109673410 cites W2007908049 @default.
- W2109673410 cites W2013371150 @default.
- W2109673410 cites W2023956150 @default.
- W2109673410 cites W2032969319 @default.
- W2109673410 cites W2036083275 @default.
- W2109673410 cites W2037656756 @default.
- W2109673410 cites W2047353791 @default.
- W2109673410 cites W2047785430 @default.
- W2109673410 cites W2049370001 @default.
- W2109673410 cites W2054800529 @default.
- W2109673410 cites W2057240378 @default.
- W2109673410 cites W2057690968 @default.
- W2109673410 cites W2066892857 @default.
- W2109673410 cites W2068711603 @default.
- W2109673410 cites W2069887029 @default.
- W2109673410 cites W2081360802 @default.
- W2109673410 cites W2082366901 @default.
- W2109673410 cites W2095566399 @default.
- W2109673410 cites W2103052595 @default.
- W2109673410 cites W2104948245 @default.
- W2109673410 cites W2106979097 @default.
- W2109673410 cites W2109213088 @default.
- W2109673410 cites W2111683372 @default.
- W2109673410 cites W2115498064 @default.
- W2109673410 cites W2118043115 @default.
- W2109673410 cites W2119696575 @default.
- W2109673410 cites W2124077788 @default.
- W2109673410 cites W2124519865 @default.
- W2109673410 cites W2124772160 @default.
- W2109673410 cites W2125431151 @default.
- W2109673410 cites W2128153109 @default.
- W2109673410 cites W2129319296 @default.
- W2109673410 cites W2130316368 @default.
- W2109673410 cites W2130822772 @default.
- W2109673410 cites W2130854755 @default.
- W2109673410 cites W2133054195 @default.
- W2109673410 cites W2136082432 @default.
- W2109673410 cites W2139620849 @default.
- W2109673410 cites W2143974552 @default.
- W2109673410 cites W2144098483 @default.
- W2109673410 cites W2144560685 @default.
- W2109673410 cites W2145336165 @default.
- W2109673410 cites W2146550739 @default.
- W2109673410 cites W2147898933 @default.
- W2109673410 cites W2149234262 @default.
- W2109673410 cites W2151633978 @default.
- W2109673410 cites W2153763947 @default.
- W2109673410 cites W2154385325 @default.
- W2109673410 cites W2156114650 @default.
- W2109673410 cites W2164097967 @default.
- W2109673410 cites W2169330513 @default.
- W2109673410 cites W2255750058 @default.
- W2109673410 cites W2409545288 @default.
- W2109673410 cites W4233838756 @default.
- W2109673410 cites W4236055423 @default.
- W2109673410 cites W66132796 @default.
- W2109673410 doi "https://doi.org/10.1128/iai.00684-12" @default.
- W2109673410 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3497425" @default.
- W2109673410 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22988014" @default.
- W2109673410 hasPublicationYear "2012" @default.
- W2109673410 type Work @default.
- W2109673410 sameAs 2109673410 @default.
- W2109673410 citedByCount "53" @default.
- W2109673410 countsByYear W21096734102013 @default.
- W2109673410 countsByYear W21096734102014 @default.
- W2109673410 countsByYear W21096734102015 @default.
- W2109673410 countsByYear W21096734102016 @default.
- W2109673410 countsByYear W21096734102017 @default.
- W2109673410 countsByYear W21096734102018 @default.
- W2109673410 countsByYear W21096734102019 @default.
- W2109673410 countsByYear W21096734102020 @default.
- W2109673410 countsByYear W21096734102021 @default.
- W2109673410 countsByYear W21096734102022 @default.
- W2109673410 countsByYear W21096734102023 @default.
- W2109673410 crossrefType "journal-article" @default.
- W2109673410 hasAuthorship W2109673410A5025123956 @default.