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• W2109677599 abstract "Benzopyrans are selective estrogen receptor (ER) β agonists (SERBAs), which bind the ER subtypes α and β in opposite orientations. Here we describe the syntheses of cyclopentanone and cyclohexanone intermediates for SAR studies of the C-ring on the benzopyran scaffold. Modification of the C-ring disrupts binding to ERα, thus improving ERβ selectivity up to 100-fold. X-ray cocrystal structures confirm previously observed binding modes." @default.
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• W2109677599 date "2007-09-01" @default.
• W2109677599 modified "2023-10-09" @default.
• W2109677599 title "Benzopyrans as selective estrogen receptor β agonists (SERBAs). Part 3: Synthesis of cyclopentanone and cyclohexanone intermediates for C-ring modification" @default.
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• W2109677599 doi "https://doi.org/10.1016/j.bmcl.2007.06.052" @default.
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