FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2109681475> ?p ?o ?g. }

• W2109681475 endingPage "33" @default.
• W2109681475 startingPage "33" @default.
• W2109681475 abstract "Hepatitis B core protein (HBVc) has been extensively studied from both a structural and immunological point of view, but the evolutionary forces driving sequence variation within core are incompletely understood.In this study, the observed variation in HBVc protein sequence has been examined in a collection of a large number of HBVc protein sequences from public sequence repositories. An alignment of several hundred sequences was carried out, and used to analyse the distribution of polymorphisms along the HBVc. Polymorphisms were found at 44 out of 185 amino acid positions analysed and were clustered predominantly in those parts of HBVc forming the outer surface and spike on intact capsid. The relationship between HBVc diversity and HBV genotype was examined. The position of variable amino acids along the sequence was examined in terms of the structural constraints of capsid and envelope assembly, and also in terms of immunological recognition by T and B cells.Over three quarters of amino acids within the HBVc sequence are non-polymorphic, and variation is focused to a few amino acids. Phylogenetic analysis suggests that core protein specific forces constrain its diversity within the context of overall HBV genome evolution. As a consequence, core protein is not a reliable predictor of virus genotype. The structural requirements of capsid assembly are likely to play a major role in limiting diversity. The phylogenetic analysis further suggests that immunological selection does not play a major role in driving HBVc diversity." @default.
• W2109681475 created "2016-06-24" @default.
• W2109681475 creator A5038209629 @default.
• W2109681475 creator A5062024371 @default.
• W2109681475 date "2005-01-01" @default.
• W2109681475 modified "2023-09-27" @default.
• W2109681475 cites W1782358917 @default.
• W2109681475 cites W1973852798 @default.
• W2109681475 cites W1992793214 @default.
• W2109681475 cites W2015932830 @default.
• W2109681475 cites W2017519756 @default.
• W2109681475 cites W2018479084 @default.
• W2109681475 cites W2029549914 @default.
• W2109681475 cites W2034679908 @default.
• W2109681475 cites W2046387499 @default.
• W2109681475 cites W2057157722 @default.
• W2109681475 cites W2060672402 @default.
• W2109681475 cites W2064645599 @default.
• W2109681475 cites W2068127052 @default.
• W2109681475 cites W2070757524 @default.
• W2109681475 cites W2073557651 @default.
• W2109681475 cites W2075501622 @default.
• W2109681475 cites W2083579463 @default.
• W2109681475 cites W2088928592 @default.
• W2109681475 cites W2092848970 @default.
• W2109681475 cites W2098459535 @default.
• W2109681475 cites W2104584414 @default.
• W2109681475 cites W2105585336 @default.
• W2109681475 cites W2105681098 @default.
• W2109681475 cites W2106882534 @default.
• W2109681475 cites W2106908798 @default.
• W2109681475 cites W2110193386 @default.
• W2109681475 cites W2112704704 @default.
• W2109681475 cites W2118951195 @default.
• W2109681475 cites W2119632499 @default.
• W2109681475 cites W2121865822 @default.
• W2109681475 cites W2122743206 @default.
• W2109681475 cites W2146614792 @default.
• W2109681475 cites W2152076818 @default.
• W2109681475 cites W2152986015 @default.
• W2109681475 cites W2153138328 @default.
• W2109681475 cites W2165068435 @default.
• W2109681475 cites W2170565120 @default.
• W2109681475 doi "https://doi.org/10.1186/1471-2180-5-33" @default.
• W2109681475 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1173110" @default.
• W2109681475 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15921513" @default.
• W2109681475 hasPublicationYear "2005" @default.
• W2109681475 type Work @default.
• W2109681475 sameAs 2109681475 @default.
• W2109681475 citedByCount "47" @default.
• W2109681475 countsByYear W21096814752013 @default.
• W2109681475 countsByYear W21096814752014 @default.
• W2109681475 countsByYear W21096814752015 @default.
• W2109681475 countsByYear W21096814752016 @default.
• W2109681475 countsByYear W21096814752017 @default.
• W2109681475 countsByYear W21096814752018 @default.
• W2109681475 countsByYear W21096814752019 @default.
• W2109681475 countsByYear W21096814752020 @default.
• W2109681475 countsByYear W21096814752021 @default.
• W2109681475 countsByYear W21096814752022 @default.
• W2109681475 countsByYear W21096814752023 @default.
• W2109681475 crossrefType "journal-article" @default.
• W2109681475 hasAuthorship W2109681475A5038209629 @default.
• W2109681475 hasAuthorship W2109681475A5062024371 @default.
• W2109681475 hasBestOaLocation W21096814751 @default.
• W2109681475 hasConcept C10010492 @default.
• W2109681475 hasConcept C104317684 @default.
• W2109681475 hasConcept C141231307 @default.
• W2109681475 hasConcept C151730666 @default.
• W2109681475 hasConcept C167625842 @default.
• W2109681475 hasConcept C193252679 @default.
• W2109681475 hasConcept C202878990 @default.
• W2109681475 hasConcept C2778112365 @default.
• W2109681475 hasConcept C2779343474 @default.
• W2109681475 hasConcept C45484198 @default.
• W2109681475 hasConcept C515207424 @default.
• W2109681475 hasConcept C54355233 @default.
• W2109681475 hasConcept C61053724 @default.
• W2109681475 hasConcept C70721500 @default.
• W2109681475 hasConcept C78458016 @default.
• W2109681475 hasConcept C86803240 @default.
• W2109681475 hasConceptScore W2109681475C10010492 @default.
• W2109681475 hasConceptScore W2109681475C104317684 @default.
• W2109681475 hasConceptScore W2109681475C141231307 @default.
• W2109681475 hasConceptScore W2109681475C151730666 @default.
• W2109681475 hasConceptScore W2109681475C167625842 @default.
• W2109681475 hasConceptScore W2109681475C193252679 @default.
• W2109681475 hasConceptScore W2109681475C202878990 @default.
• W2109681475 hasConceptScore W2109681475C2778112365 @default.
• W2109681475 hasConceptScore W2109681475C2779343474 @default.
• W2109681475 hasConceptScore W2109681475C45484198 @default.
• W2109681475 hasConceptScore W2109681475C515207424 @default.
• W2109681475 hasConceptScore W2109681475C54355233 @default.
• W2109681475 hasConceptScore W2109681475C61053724 @default.
• W2109681475 hasConceptScore W2109681475C70721500 @default.
• W2109681475 hasConceptScore W2109681475C78458016 @default.
• W2109681475 hasConceptScore W2109681475C86803240 @default.
• W2109681475 hasIssue "1" @default.

• next