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• W2109682215 endingPage "E241" @default.
• W2109682215 startingPage "E234" @default.
• W2109682215 abstract "Calcium-related proteins include the calcium transporters 1 and 2 (CaT1 and CaT2), plasma membrane Ca 2+ -ATPase 1b (PMCA1b), and calbindin-D9k and -D28k. The expression of CaT1 and PMCA1b and their potential roles in the uterine tissue remain to be clarified. Thus, in the present study, the expression patterns of CaT1 and PMCA1b were examined to predict their roles in rat uterus during the estrous cycle. Both CaT1 and PMCA1b mRNAs were detected in rat uterus. Uterine CaT1 mRNA was highly expressed at diestrus compared with proestrus, whereas PMCA1b expression was not altered during the estrus cycle. To evaluate the sex steroids involved in uterine CaT1 mRNA regulation, 17β-estradiol (E 2 ) and/or progesterone (P 4 ) were injected into immature rats. Treatment with P 4 or E 2 plus P 4 resulted in an increase in CaT1 mRNA, but a synergetic effect of E 2 plus P 4 was not detected. Uterine CaT1 mRNA was induced by P 4 in a time- and dose-dependent manner, with maximal transcript detected 12 h after the final P 4 injection. Treatment with RU486, a progesterone receptor (PR) antagonist, completely blocked P 4 -induced CaT1 mRNA, indicating that P 4 regulates CaT1 mRNA expression via a PR-mediated pathway. In addition, CaT1 mRNA was expressed in uterine endometrium and glandular endometrium at diestrus in P 4 -treated rats. Together, these results suggest that CaT1 is regulated by P 4 at diestrus via a PR-dependent pathway." @default.
• W2109682215 created "2016-06-24" @default.
• W2109682215 creator A5019148333 @default.
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• W2109682215 creator A5024635161 @default.
• W2109682215 creator A5061468544 @default.
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• W2109682215 date "2006-08-01" @default.
• W2109682215 modified "2023-10-15" @default.
• W2109682215 title "Differential expression of uterine calcium transporter 1 and plasma membrane Ca²⁺ATPase 1b during rat estrous cycle" @default.
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• W2109682215 doi "https://doi.org/10.1152/ajpendo.00434.2005" @default.
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• W2109682215 hasPublicationYear "2006" @default.
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