FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2109686486> ?p ?o ?g. }

• W2109686486 endingPage "7873" @default.
• W2109686486 startingPage "7867" @default.
• W2109686486 abstract "The ability to detect pathogens is arguably the single most important task undertaken by the immune system. Appropriate recognition of invasive microbes is critical for mounting an immune response that can effectively combat the invading organism. A comprehensive understanding of the requirements for pathogen recognition is necessary for the development of efficacious vaccines and effective therapeutics. Toward this end, a tremendous investment has been made in determining how the adaptive immune system (B and T cells) distinguishes invading pathogens from host cells and tissues. These efforts have yielded remarkable models that describe how the immune system responds to the myriad of challenges it faces and provide a framework into which future discoveries can be incorporated. Recently, however, some of this focus has been redirected to understanding how pathogens are initially recognized by the host innate immune system and how these events contribute to and coordinate with the adaptive immune response.Detection of pathogens by the innate immune system is carried out by a class of immune-sensor molecules termed pattern recognition receptors, or PRRs. Several different classes of PRRs have been identified, each detecting microbes or microbial components and initiating responses that program antipathogen gene expression profiles and promote adaptive immune responses (28). The Toll-like receptors (TLRs) are a class of PRRs that detect an increasingly broad range of pathogens (74). While the majority of the work on TLRs has focused on detection of bacteria, it is becoming increasingly apparent that viruses are also subject to innate sensing by TLRs. An indicator of the importance of any host antiviral strategy is the ability of viruses to counteract that particular arm of the host defense. Two vaccinia virus genes, A46R and A52R, have been implicated as negative regulators of TLR signaling, indicating that TLR responses pose a realistic threat to viruses (11a, 29a). This review will focus on the state of our knowledge of TLRs' role in immune responses to viruses." @default.
• W2109686486 created "2016-06-24" @default.
• W2109686486 creator A5003203308 @default.
• W2109686486 creator A5079400243 @default.
• W2109686486 date "2004-08-01" @default.
• W2109686486 modified "2023-10-10" @default.
• W2109686486 title "Innate Sensing of Viruses by Toll-Like Receptors" @default.
• W2109686486 cites W10482017 @default.
• W2109686486 cites W118616534 @default.
• W2109686486 cites W1483162601 @default.
• W2109686486 cites W1499978168 @default.
• W2109686486 cites W1514540900 @default.
• W2109686486 cites W1517310071 @default.
• W2109686486 cites W1519843522 @default.
• W2109686486 cites W1600236870 @default.
• W2109686486 cites W1667782349 @default.
• W2109686486 cites W1766658148 @default.
• W2109686486 cites W1966772446 @default.
• W2109686486 cites W1967879964 @default.
• W2109686486 cites W1969072247 @default.
• W2109686486 cites W1972140057 @default.
• W2109686486 cites W1972776583 @default.
• W2109686486 cites W1973157062 @default.
• W2109686486 cites W1978962348 @default.
• W2109686486 cites W1980273234 @default.
• W2109686486 cites W1980768668 @default.
• W2109686486 cites W1989656760 @default.
• W2109686486 cites W1990698093 @default.
• W2109686486 cites W1991236592 @default.
• W2109686486 cites W1991484745 @default.
• W2109686486 cites W1994391392 @default.
• W2109686486 cites W1995866508 @default.
• W2109686486 cites W1996120614 @default.
• W2109686486 cites W1996736315 @default.
• W2109686486 cites W1998211335 @default.
• W2109686486 cites W1998585620 @default.
• W2109686486 cites W2003385732 @default.
• W2109686486 cites W2004726009 @default.
• W2109686486 cites W2006772331 @default.
• W2109686486 cites W2013601771 @default.
• W2109686486 cites W2024184282 @default.
• W2109686486 cites W2029157767 @default.
• W2109686486 cites W2030611349 @default.
• W2109686486 cites W2037368492 @default.
• W2109686486 cites W2052932569 @default.
• W2109686486 cites W2056092077 @default.
• W2109686486 cites W2059038780 @default.
• W2109686486 cites W2064626913 @default.
• W2109686486 cites W2069981713 @default.
• W2109686486 cites W2070045384 @default.
• W2109686486 cites W2070597700 @default.
• W2109686486 cites W2075300931 @default.
• W2109686486 cites W2075928204 @default.
• W2109686486 cites W2076361525 @default.
• W2109686486 cites W2082890018 @default.
• W2109686486 cites W2086545805 @default.
• W2109686486 cites W2086921694 @default.
• W2109686486 cites W2092751085 @default.
• W2109686486 cites W2093508027 @default.
• W2109686486 cites W2096726255 @default.
• W2109686486 cites W2098901296 @default.
• W2109686486 cites W2101363646 @default.
• W2109686486 cites W2108242883 @default.
• W2109686486 cites W2108889221 @default.
• W2109686486 cites W2110161909 @default.
• W2109686486 cites W2110827592 @default.
• W2109686486 cites W2114637517 @default.
• W2109686486 cites W2114739240 @default.
• W2109686486 cites W2116692899 @default.
• W2109686486 cites W2120388636 @default.
• W2109686486 cites W2120457974 @default.
• W2109686486 cites W2129319296 @default.
• W2109686486 cites W2130322182 @default.
• W2109686486 cites W2130421043 @default.
• W2109686486 cites W2132282141 @default.
• W2109686486 cites W2133369735 @default.
• W2109686486 cites W2134224958 @default.
• W2109686486 cites W2135806909 @default.
• W2109686486 cites W2137590150 @default.
• W2109686486 cites W2137594178 @default.
• W2109686486 cites W2139266436 @default.
• W2109686486 cites W2144575453 @default.
• W2109686486 cites W2145162535 @default.
• W2109686486 cites W2148178789 @default.
• W2109686486 cites W2148387062 @default.
• W2109686486 cites W2151777859 @default.
• W2109686486 cites W2154280240 @default.
• W2109686486 cites W2161208630 @default.
• W2109686486 cites W2166411505 @default.
• W2109686486 cites W2171260427 @default.
• W2109686486 cites W2474521317 @default.
• W2109686486 doi "https://doi.org/10.1128/jvi.78.15.7867-7873.2004" @default.
• W2109686486 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/446107" @default.
• W2109686486 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15254159" @default.
• W2109686486 hasPublicationYear "2004" @default.
• W2109686486 type Work @default.
• W2109686486 sameAs 2109686486 @default.
• W2109686486 citedByCount "246" @default.

• next