FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2109690807> ?p ?o ?g. }

• W2109690807 abstract "Acidity is a hallmark of malignant tumor, representing a very efficient mechanism of chemoresistance. Proton pump inhibitors (PPI) at high dosage have been shown to sensitize chemoresistant human tumor cells and tumors to cytotoxic molecules. The aim of this pilot study was to investigate the efficacy of PPI in improving the clinical outcome of docetaxel + cisplatin regimen in patients with metastatic breast cancer (MBC).Patients enrolled were randomly assigned to three arms: Arm A, docetaxel 75 mg/m(2) followed by cisplatin 75 mg/m(2) on d4, repeated every 21 days with a maximum of 6 cycles; Arm B, the same chemotherapy preceded by three days esomeprazole (ESOM) 80 mg p.o. bid, beginning on d1 repeated weekly. Weekly intermittent administration of ESOM (3 days on 4 days off) was maintained up to maximum 66 weeks; Arm C, the same as Arm B with the only difference being dose of ESOM at 100 mg p.o. bid. The primary endpoint was response rate.Ninety-four patients were randomly assigned and underwent at least one injection of chemotherapy. Response rates for arm A, B and C were 46.9, 71.0, and 64.5 %, respectively. Median TTP for arm A (n = 32), B (n = 31), C (n = 31) were 8.7, 9.4, and 9.7 months, respectively. A significant difference was observed between patients who had taken PPI and who not with ORR (67.7 % vs. 46.9 %, p = 0.049) and median TTP (9.7 months vs. 8.7 months, p = 0.045) [corrected]. Exploratory analysis showed that among 15 patients with triple negative breast cancer (TNBC), this difference was bigger with median TTP of 10.7 and 5.8 months, respectively (p = 0.011). PPI combination showed a marked effect on OS as well, while with a borderline significance (29.9 vs. 19.2 months, p = 0.090). No additional toxicity was observed with PPI.The results of this pilot clinical trial showed that intermittent high dose PPI enhance the antitumor effects of chemotherapy in MBC patients without evidence of additional toxicity, which requires urgent validation in a multicenter, randomized, phase III trial.Clinicaltrials.gov identifier: NCT01069081 ." @default.
• W2109690807 created "2016-06-24" @default.
• W2109690807 creator A5004906186 @default.
• W2109690807 creator A5007477169 @default.
• W2109690807 creator A5008077481 @default.
• W2109690807 creator A5013248801 @default.
• W2109690807 creator A5017991798 @default.
• W2109690807 creator A5039369753 @default.
• W2109690807 creator A5040118875 @default.
• W2109690807 creator A5055725983 @default.
• W2109690807 creator A5057209439 @default.
• W2109690807 creator A5071420544 @default.
• W2109690807 creator A5073681238 @default.
• W2109690807 creator A5076503165 @default.
• W2109690807 date "2015-08-22" @default.
• W2109690807 modified "2023-10-13" @default.
• W2109690807 title "Intermittent high dose proton pump inhibitor enhances the antitumor effects of chemotherapy in metastatic breast cancer" @default.
• W2109690807 cites W10911041 @default.
• W2109690807 cites W110073676 @default.
• W2109690807 cites W1501700213 @default.
• W2109690807 cites W1514403557 @default.
• W2109690807 cites W1576826397 @default.
• W2109690807 cites W1784699277 @default.
• W2109690807 cites W1787102412 @default.
• W2109690807 cites W1789390095 @default.
• W2109690807 cites W1965335179 @default.
• W2109690807 cites W1968205399 @default.
• W2109690807 cites W1968589583 @default.
• W2109690807 cites W1974493081 @default.
• W2109690807 cites W1989892130 @default.
• W2109690807 cites W1991783248 @default.
• W2109690807 cites W1992507370 @default.
• W2109690807 cites W1994416882 @default.
• W2109690807 cites W1995862560 @default.
• W2109690807 cites W1995943575 @default.
• W2109690807 cites W1996088849 @default.
• W2109690807 cites W2007193116 @default.
• W2109690807 cites W2010884061 @default.
• W2109690807 cites W2013735638 @default.
• W2109690807 cites W2015620660 @default.
• W2109690807 cites W2024961744 @default.
• W2109690807 cites W2026106791 @default.
• W2109690807 cites W2029272680 @default.
• W2109690807 cites W2039331746 @default.
• W2109690807 cites W2046585193 @default.
• W2109690807 cites W2052562816 @default.
• W2109690807 cites W2054077259 @default.
• W2109690807 cites W2056882023 @default.
• W2109690807 cites W2060315853 @default.
• W2109690807 cites W2061001280 @default.
• W2109690807 cites W2061184351 @default.
• W2109690807 cites W2068734842 @default.
• W2109690807 cites W2080392472 @default.
• W2109690807 cites W2080550678 @default.
• W2109690807 cites W2081371902 @default.
• W2109690807 cites W2082662845 @default.
• W2109690807 cites W2084235230 @default.
• W2109690807 cites W2084271408 @default.
• W2109690807 cites W2088112305 @default.
• W2109690807 cites W2096535852 @default.
• W2109690807 cites W2096955328 @default.
• W2109690807 cites W2097259163 @default.
• W2109690807 cites W2099810479 @default.
• W2109690807 cites W2101235315 @default.
• W2109690807 cites W2101431866 @default.
• W2109690807 cites W2101697301 @default.
• W2109690807 cites W2102577783 @default.
• W2109690807 cites W2104824311 @default.
• W2109690807 cites W2120252048 @default.
• W2109690807 cites W2128414062 @default.
• W2109690807 cites W2131090274 @default.
• W2109690807 cites W2131770017 @default.
• W2109690807 cites W2136224372 @default.
• W2109690807 cites W2142226415 @default.
• W2109690807 cites W2143433681 @default.
• W2109690807 cites W2144701578 @default.
• W2109690807 cites W2146037312 @default.
• W2109690807 cites W2146226748 @default.
• W2109690807 cites W2149721689 @default.
• W2109690807 cites W2154532579 @default.
• W2109690807 cites W2156687584 @default.
• W2109690807 cites W2159329940 @default.
• W2109690807 cites W2160064267 @default.
• W2109690807 cites W2160251189 @default.
• W2109690807 cites W2165093451 @default.
• W2109690807 cites W2171444389 @default.
• W2109690807 cites W2415954309 @default.
• W2109690807 cites W2423249990 @default.
• W2109690807 doi "https://doi.org/10.1186/s13046-015-0194-x" @default.
• W2109690807 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4589907" @default.
• W2109690807 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26427752" @default.
• W2109690807 hasPublicationYear "2015" @default.
• W2109690807 type Work @default.
• W2109690807 sameAs 2109690807 @default.
• W2109690807 citedByCount "124" @default.
• W2109690807 countsByYear W21096908072015 @default.
• W2109690807 countsByYear W21096908072016 @default.
• W2109690807 countsByYear W21096908072017 @default.
• W2109690807 countsByYear W21096908072018 @default.
• W2109690807 countsByYear W21096908072019 @default.

• next